Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /BrnT(toxin)
Location 453624..454110 Replicon chromosome
Accession NC_007484
Organism Nitrosococcus oceani ATCC 19707

Toxin (Protein)


Gene name - Uniprot ID Q3JE10
Locus tag NOC_RS02290 Protein ID WP_002813819.1
Coordinates 453624..453887 (+) Length 88 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q3JE09
Locus tag NOC_RS02295 Protein ID WP_002811890.1
Coordinates 453877..454110 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NOC_RS02260 449181..449738 + 558 WP_011330329.1 hypothetical protein -
NOC_RS02265 450015..451019 + 1005 WP_002814094.1 DUF4917 family protein -
NOC_RS02270 451070..451612 + 543 WP_002812449.1 hypothetical protein -
NOC_RS02275 451696..452286 + 591 WP_002812842.1 AbiV family abortive infection protein -
NOC_RS02280 452359..452760 + 402 WP_002813368.1 hypothetical protein -
NOC_RS17615 453253..453477 + 225 WP_002812093.1 hypothetical protein -
NOC_RS02290 453624..453887 + 264 WP_002813819.1 BrnT family toxin Toxin
NOC_RS02295 453877..454110 + 234 WP_002811890.1 hypothetical protein Antitoxin
NOC_RS02300 454435..454638 + 204 WP_002812826.1 type II toxin-antitoxin system HicA family toxin -
NOC_RS02305 454635..454856 + 222 WP_002812133.1 hypothetical protein -
NOC_RS17225 455043..455393 + 351 WP_147094530.1 IS3 family transposase -
NOC_RS02315 455465..455866 - 402 WP_002812571.1 PIN domain nuclease -
NOC_RS02320 455863..456057 - 195 WP_013221529.1 type II toxin-antitoxin system VapB family antitoxin -
NOC_RS02325 456651..456919 + 269 Protein_435 HigA family addiction module antidote protein -
NOC_RS17620 456934..457089 - 156 WP_155814832.1 hypothetical protein -
NOC_RS16610 457148..457426 + 279 WP_011330332.1 type II toxin-antitoxin system RelE/ParE family toxin -
NOC_RS02335 457440..457754 + 315 WP_002812155.1 HigA family addiction module antidote protein -
NOC_RS02340 457955..458272 + 318 WP_036497885.1 hypothetical protein -
NOC_RS02345 458339..458572 + 234 WP_036497888.1 hypothetical protein -
NOC_RS02350 458611..458796 - 186 WP_036497891.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 218606..467181 248575
- inside Integron - - 448476..455455 6979


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(6-81)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10140.49 Da        Isoelectric Point: 6.4719

>T21265 WP_002813819.1 NC_007484:453624-453887 [Nitrosococcus oceani ATCC 19707]
MYTFEFDERKSNGNRRKHGIDFVEAQALWSDPYLMEIPALTSDEERFLVIGKIEGKHWSAVITPRNGNIRIISVRRSRVE
EVAIYEG

Download         Length: 264 bp

>T21265 NC_007484:453624-453887 [Nitrosococcus oceani ATCC 19707]
ATGTACACCTTCGAATTTGATGAGCGAAAGAGCAACGGCAATCGGCGCAAACACGGCATCGATTTCGTCGAAGCCCAAGC
GCTTTGGAGCGATCCCTATCTCATGGAAATCCCAGCGTTAACGTCCGATGAAGAGCGTTTTCTGGTAATCGGCAAAATCG
AAGGGAAGCACTGGTCGGCGGTCATTACGCCCCGAAATGGCAACATCCGAATAATCTCGGTGCGCCGCTCACGGGTTGAA
GAGGTAGCAATTTATGAAGGCTAA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8889.21 Da        Isoelectric Point: 10.5573

>AT21265 WP_002811890.1 NC_007484:453877-454110 [Nitrosococcus oceani ATCC 19707]
MKAKSFDAKFEKGEDVTKSLDLSKARRPLQEQRRVNVDFPAWMVESLDREAGRLGVTRQSVIKVWLAERLEQIASNK

Download         Length: 234 bp

>AT21265 NC_007484:453877-454110 [Nitrosococcus oceani ATCC 19707]
ATGAAGGCTAAGAGCTTTGATGCGAAATTCGAGAAAGGCGAAGATGTCACCAAATCCTTGGATCTGTCCAAAGCGCGGAG
GCCCCTTCAAGAACAGCGCAGGGTAAATGTCGATTTTCCGGCTTGGATGGTCGAATCCCTGGATCGGGAGGCAGGGCGTT
TGGGTGTTACGCGGCAATCGGTAATTAAAGTTTGGTTGGCTGAGCGCCTTGAGCAAATAGCTTCTAACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E2Z5H7

Antitoxin

Source ID Structure
AlphaFold DB A0A0E2ZQB4

References