Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc(toxin)
Location 5675669..5676237 Replicon chromosome
Accession NZ_CP081178
Organism Pseudomonas mandelii strain KGI_MA19

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag K3369_RS25585 Protein ID WP_221107279.1
Coordinates 5675669..5676067 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag K3369_RS25590 Protein ID WP_094065496.1
Coordinates 5676067..5676237 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K3369_RS25570 (K3369_25570) 5670864..5672612 - 1749 WP_245006780.1 ATP-binding protein -
K3369_RS25575 (K3369_25575) 5672609..5673646 - 1038 WP_221107276.1 SIR2 family protein -
K3369_RS25580 (K3369_25580) 5673850..5675292 + 1443 WP_221107278.1 hypothetical protein -
K3369_RS25585 (K3369_25585) 5675669..5676067 - 399 WP_221107279.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
K3369_RS25590 (K3369_25590) 5676067..5676237 - 171 WP_094065496.1 acetyltransferase Antitoxin
K3369_RS25595 (K3369_25595) 5676806..5678383 - 1578 WP_221107281.1 glutamine-hydrolyzing GMP synthase -
K3369_RS25600 (K3369_25600) 5678482..5679951 - 1470 WP_010457821.1 IMP dehydrogenase -
K3369_RS25605 (K3369_25605) 5680069..5680617 - 549 WP_221107283.1 sugar ABC transporter ATPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 5672609..5684529 11920


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(10-120)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14542.51 Da        Isoelectric Point: 3.9682

>T212643 WP_221107279.1 NZ_CP081178:c5676067-5675669 [Pseudomonas mandelii]
MELIFFPFERVIEINTQILTTEPGMKGPVNIPLLQGALARIDNAIAYDGLDDVFEIAAKYTASIARGHALPDANKRTGLA
VGLEYLSLNDYEVTLDNDLIADAVRDLVIGEINEHDFADILYSCFIASQNQI

Download         Length: 399 bp

>T212643 NZ_CP107308:356117-356464 [Klebsiella pneumoniae]
ATGTGGGATGTAGAAACGACGGATACGTTTGATGCCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCCTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTGCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTGTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGTGGGCAATAAGGATGGCATGAATGAGAAACGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6357.53 Da        Isoelectric Point: 10.6914

>AT212643 WP_094065496.1 NZ_CP081178:c5676237-5676067 [Pseudomonas mandelii]
MNHKLNTYGVSIVERPKVKAIKKLDLGGDSGKQIVYSETKLVLRTHKKTFQKLADM

Download         Length: 171 bp

>AT212643 NZ_CP107308:356464-356763 [Klebsiella pneumoniae]
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGATAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGGCTGATAACGACCCTCGGCTTTCGACCCTAAAACGCTACATTGCGGCATTGGGG
GGAGAACTCAGTATAAATGTCACATTGCCGACTGGAAAAAAAGTCTCGTTTAATTTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References