Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /SpoIISA(toxin)
Location 2316248..2317223 Replicon chromosome
Accession NZ_CP081175
Organism Bacillus anthracis strain P04210076

Toxin (Protein)


Gene name spoIISA Uniprot ID A0A2R2IKP2
Locus tag K0029_RS12095 Protein ID WP_002036394.1
Coordinates 2316248..2316985 (+) Length 246 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID R8HWP4
Locus tag K0029_RS12100 Protein ID WP_000588712.1
Coordinates 2317098..2317223 (+) Length 42 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K0029_RS12075 (K0029_12075) 2311976..2312758 + 783 WP_000381787.1 class I SAM-dependent methyltransferase -
K0029_RS12080 (K0029_12080) 2312880..2314565 - 1686 WP_009879073.1 alpha-keto acid decarboxylase family protein -
K0029_RS12085 (K0029_12085) 2314672..2315154 + 483 WP_000191911.1 MarR family winged helix-turn-helix transcriptional regulator -
K0029_RS12090 (K0029_12090) 2315322..2316059 + 738 WP_000594139.1 2,3-diphosphoglycerate-dependent phosphoglycerate mutase -
K0029_RS12095 (K0029_12095) 2316248..2316985 + 738 WP_002036394.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
K0029_RS12100 (K0029_12100) 2317098..2317223 + 126 WP_000588712.1 hypothetical protein Antitoxin
K0029_RS12105 (K0029_12105) 2317300..2317476 + 177 WP_000852614.1 hypothetical protein -
K0029_RS12110 (K0029_12110) 2317513..2317794 - 282 WP_001041555.1 hypothetical protein -
K0029_RS12115 (K0029_12115) 2318071..2318307 - 237 WP_001021689.1 hypothetical protein -
K0029_RS28850 2318444..2318569 + 126 WP_000694311.1 hypothetical protein -
K0029_RS12120 (K0029_12120) 2318646..2318822 + 177 WP_000808045.1 stage II sporulation protein SB -
K0029_RS12125 (K0029_12125) 2318966..2320435 + 1470 WP_221082137.1 beta-Ala-His dipeptidase -
K0029_RS12130 (K0029_12130) 2320999..2321469 - 471 WP_000670597.1 DUF5065 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(9-243)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 246 a.a.        Molecular weight: 28373.03 Da        Isoelectric Point: 8.2705

>T212639 WP_002036394.1 NZ_CP081175:2316248-2316985 [Bacillus anthracis]
VISNIRIGLFILAIVFLVLVFFYWRNEELYEEKKQRIRKTWYGLFIVSVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIAF
ILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPAVFGTMEWHTEEEYTKSLNAFLDSYGEKIGAKI
VVFEAAKELNTNFRGIRSQFSTIIPLEYIEQLNEQRAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIHH
SYFSK

Download         Length: 738 bp

>T212639 NZ_CP107304:c65802-65386 [Klebsiella pneumoniae]
GTGAACAAGACCTATATGCTCGACACCTGTATCTGCTCGTTCATCATGCGCGAGCAGCCGGAAGCCGTCCTGAAGCGCCT
GGAGCAGGCGGTGCTGCGCGGCCAGCGCATCGTTGTCTCGGCCATCACTTATTCTGAAATGCGCTTCGGGGCCACCGGCC
CGAAGGCCTCCCCGCGCCACGTCGAGCTGGTCGACGCGTTCTGCGCCCGCCTCGATGCCATCCTGCCCTGGGATCGCGCT
GCGGTGGACGCCACCACGGAGATTAAGGTGGCGCTGCGAATGGCCGGGACGCCGATCGGCCCGAACGACACGGCCATTGC
CGGGCACGCCATCGCCGCCGGTGCCGTGCTGGTGACGAATAATACGCGGGAATTTGAGCGGGTACCGGGTCTTGTGCTGG
AAGACTGGGTAAGATAA

Antitoxin


Download         Length: 42 a.a.        Molecular weight: 4938.34 Da        Isoelectric Point: 3.9150

>AT212639 WP_000588712.1 NZ_CP081175:2317098-2317223 [Bacillus anthracis]
VIKDYDNDFFKEDNEDTTDFSLIKGDTLQQVEELEEELKRK

Download         Length: 126 bp

>AT212639 NZ_CP107304:c66029-65799 [Klebsiella pneumoniae]
ATGAGAACTGTATCCATTTTTAAAAACGGCAATAACCGCGCCATTCGTCTGCCCCGCGATCTGGATTTTGAGGGAGTGAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATTATTTTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGTTCG
AGAAGGCAGACCCGGACTTTATGGCGGAGCGCGAGGACGTTGTCAGCGACGAAGGACGATTTAACCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2R2IKP2

Antitoxin

Source ID Structure
AlphaFold DB A0A366GQT1

References