Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1682893..1683532 Replicon chromosome
Accession NZ_CP081135
Organism Terrisporobacter hibernicus strain MCA3

Toxin (Protein)


Gene name mazF Uniprot ID A0A1I3S8W3
Locus tag JW646_RS08090 Protein ID WP_074919675.1
Coordinates 1682893..1683258 (-) Length 122 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A1I3S8L8
Locus tag JW646_RS08095 Protein ID WP_018591921.1
Coordinates 1683251..1683532 (-) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JW646_RS08070 (JW646_08070) 1678163..1680175 - 2013 WP_228417235.1 methyl-accepting chemotaxis protein -
JW646_RS08075 (JW646_08075) 1680417..1680842 - 426 WP_074919672.1 hypothetical protein -
JW646_RS08080 (JW646_08080) 1680990..1681919 - 930 WP_228417237.1 transketolase family protein -
JW646_RS08085 (JW646_08085) 1681912..1682739 - 828 WP_074919674.1 transketolase -
JW646_RS08090 (JW646_08090) 1682893..1683258 - 366 WP_074919675.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
JW646_RS08095 (JW646_08095) 1683251..1683532 - 282 WP_018591921.1 hypothetical protein Antitoxin
JW646_RS08100 (JW646_08100) 1683867..1684460 - 594 WP_228417238.1 germination lipoprotein GerS -
JW646_RS08105 (JW646_08105) 1685060..1685323 - 264 WP_083399426.1 F0F1 ATP synthase subunit epsilon -
JW646_RS08110 (JW646_08110) 1685327..1686721 - 1395 WP_228417240.1 F0F1 ATP synthase subunit beta -
JW646_RS08115 (JW646_08115) 1686734..1687603 - 870 WP_148556997.1 ATP synthase F1 subunit gamma -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(9-116)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 122 a.a.        Molecular weight: 13438.62 Da        Isoelectric Point: 9.7348

>T212637 WP_074919675.1 NZ_CP081135:c1683258-1682893 [Terrisporobacter hibernicus]
MNNLGLDIKRGDLFYADLSPVIGSEQGGVRPVLIIQNNIGNKYSPTVIIAAITSQINKAKLPTHIEISSSEYGLNKDSVI
LLEQIRTIDKKRLREKIGYLDNKTMLKVNNGLQISLDLFSI

Download         Length: 366 bp

>T212637 NZ_CP107303:5438719-5440041 [Klebsiella pneumoniae]
ATGGCGACGCTTACCACCTGGATGAACAATGTGCGCGTGGGAACCTTAACCCGCCAGGCTAACGGGGCGCACAGTTTTCG
CTATGACGAAGAGTGGCTGCGCAGCCCGCGCGCCAGACCGCTCTCCCTCTCACTGCCGCTGCAGTATGGCAATATCACTG
CCGACGCGGTGTATCACTATTTTGATAACCTGCTGCCCGACAGCCCGCAGGTCCGCGACCGGATCGTCAGGCGCTATCAG
GCGCGCTCGAAGCAGCCGTTCGATCTGCTGGCCGAAGTCGGGCGGGATAGCGTAGGGGCGGTGACCCTCCTGCCGCCGGG
GGAAGAGGCGCACCTGGAAGGATTACGCTGGCAGACGCTGGACGAGGCGCAGCTCACCGCTTTGCTGACCGCTTACCAGT
CGGATATCCCCCTCGGGATGATTACCAGCCAGGACGATTTCCGTATCTCGGTGGCCGGCGCCCAGGAGAAAACGGCGCTG
CTGCGGATGGGCGAGCAGTGGTGTATTCCGCAGGGCGCCACGCCGACCACGCATATCATTAAGCTGCCCATCGGCGAGAT
CAAGCAGCCCAATGCGACGCTGGATCTGCGTGAAAGCGTGGATAATGAGTATCTGTGCCTGGCGCTGGCCAGAGAACTGG
GCCTGGCGGTGCCGGAAGCGGAGATCATCACCACCCCGCGGATCCGCGCCCTGGCGGTAACCCGCTTCGACCGGCGCTGG
GCGCAGGAGGGACGGGTGCTGCTGCGTCTGCCGCAGGAGGATCTGTGTCAGGCTTTTGGTCTTCCTTCAGCGATGAAATA
TGAGTCTGACGGCGGGCCGGGTATCGCCGCGATCATGACCTTTCTGCTGGGCTCGAGTGAAGCGCTGAAAGATCGCTATG
ACTTTATGAAGTTCATGGTCTTCCAGTGGCTGACGGGGGCGACGGACGGTCACGCAAAAAACTTCTCAATTTACCTGTTG
CCCGGCGGCAGCTACCGCTTAACACCGTTCTACGACATTATTTCGGCGTTTCCGGTGCTGGGCGGCACGGGACTGCATCT
GCGCGATCTGAAGCTGTCGATGGGGCTCAATGCCACAAAAGGGCGTAAAACAGAGATTAACGCCATCTATCCGCGTCATT
TTCTGGCGACGGCCAAAGCGGTGAACTTTCCCCTGGAGCAGATGCTGGCGATCCTCCAGGAGTTTGCCGGGCATGTGCCG
CAGGCAATCGAAAGCGCTCGCCGGACGCTGCCGGCGGACTTTTCCAGCCACGTCTGGCAGGCCATTACAGAGAACATGCT
GAAGCTGCACGCCCGCCTGCAGCAAGGGCTGCAGGCGCTATAG

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10642.13 Da        Isoelectric Point: 4.4356

>AT212637 WP_018591921.1 NZ_CP081135:c1683532-1683251 [Terrisporobacter hibernicus]
VSNKNKEKIMFTLPDYILSEVDQIVQMENSNREDFAKAAFQFYITQKKKINLKESMIKGYKEMAKINLSLAELGMTDDVS
LDDDSEGDIAKVE

Download         Length: 282 bp

>AT212637 NZ_CP107303:5438453-5438719 [Klebsiella pneumoniae]
ATGAATTCCCCGCAGATATACAGTCCCGTGCAGCTGGCCAATTACCTGAAGCTGCTGCGCCAGCAGAACCACTGGACCCA
GGATGCGCTGGCCAGGCGGATCGGCATTAAGCAGGCCACGCTGTCCAATTTTGAAAATCACCCCGACAAAACCACCTTAA
CCACGCTGTTTAAGATCCTCCAGTCGCTGGGGGTGGTGATGACGCTGAACGCCAAAGCTGCTGAGACGGCGCCGGCTCCC
GATAACAACACGGACCTTGACTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1I3S8W3

Antitoxin

Source ID Structure
AlphaFold DB A0A1I3S8L8

References