Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapBC/PIN-MazE |
| Location | 13641..14253 | Replicon | plasmid unnamed1 |
| Accession | NZ_CP081114 | ||
| Organism | Sulfitobacter sp. M368 | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | - |
| Locus tag | K3754_RS19100 | Protein ID | WP_259943537.1 |
| Coordinates | 13641..14036 (-) | Length | 132 a.a. |
Antitoxin (Protein)
| Gene name | vapB | Uniprot ID | - |
| Locus tag | K3754_RS19105 | Protein ID | WP_055296342.1 |
| Coordinates | 14026..14253 (-) | Length | 76 a.a. |
Genomic Context
Location: 10938..12035 (1098 bp)
Type: Others
Protein ID: WP_259943528.1
Type: Others
Protein ID: WP_259943528.1
Location: 12767..13579 (813 bp)
Type: Others
Protein ID: WP_259943588.1
Type: Others
Protein ID: WP_259943588.1
Location: 14490..15677 (1188 bp)
Type: Others
Protein ID: WP_259943540.1
Type: Others
Protein ID: WP_259943540.1
Location: 15674..16690 (1017 bp)
Type: Others
Protein ID: WP_259943543.1
Type: Others
Protein ID: WP_259943543.1
Location: 16867..18087 (1221 bp)
Type: Others
Protein ID: WP_259943546.1
Type: Others
Protein ID: WP_259943546.1
Location: 9230..9838 (609 bp)
Type: Others
Protein ID: WP_259943587.1
Type: Others
Protein ID: WP_259943587.1
Location: 9853..10812 (960 bp)
Type: Others
Protein ID: WP_259943526.1
Type: Others
Protein ID: WP_259943526.1
Location: 12042..12377 (336 bp)
Type: Others
Protein ID: WP_259943531.1
Type: Others
Protein ID: WP_259943531.1
Location: 12374..12631 (258 bp)
Type: Others
Protein ID: WP_259943534.1
Type: Others
Protein ID: WP_259943534.1
Location: 13641..14036 (396 bp)
Type: Toxin
Protein ID: WP_259943537.1
Type: Toxin
Protein ID: WP_259943537.1
Location: 14026..14253 (228 bp)
Type: Antitoxin
Protein ID: WP_055296342.1
Type: Antitoxin
Protein ID: WP_055296342.1
Location: 18223..18564 (342 bp)
Type: Others
Protein ID: Protein_20
Type: Others
Protein ID: Protein_20
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Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| K3754_RS19070 (K3754_19015) | 9230..9838 | - | 609 | WP_259943587.1 | SMC-Scp complex subunit ScpB | - |
| K3754_RS19075 (K3754_19020) | 9853..10812 | - | 960 | WP_259943526.1 | DUF1403 family protein | - |
| K3754_RS19080 (K3754_19025) | 10938..12035 | + | 1098 | WP_259943528.1 | tyrosine-type recombinase/integrase | - |
| K3754_RS19085 (K3754_19030) | 12042..12377 | - | 336 | WP_259943531.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| K3754_RS19090 (K3754_19035) | 12374..12631 | - | 258 | WP_259943534.1 | type II toxin-antitoxin system ParD family antitoxin | - |
| K3754_RS19095 (K3754_19040) | 12767..13579 | + | 813 | WP_259943588.1 | recombinase family protein | - |
| K3754_RS19100 (K3754_19045) | 13641..14036 | - | 396 | WP_259943537.1 | PIN domain-containing protein | Toxin |
| K3754_RS19105 (K3754_19050) | 14026..14253 | - | 228 | WP_055296342.1 | AbrB/MazE/SpoVT family DNA-binding domain-containing protein | Antitoxin |
| K3754_RS19110 (K3754_19055) | 14490..15677 | + | 1188 | WP_259943540.1 | plasmid partitioning protein RepA | - |
| K3754_RS19115 (K3754_19060) | 15674..16690 | + | 1017 | WP_259943543.1 | plasmid partitioning protein RepB | - |
| K3754_RS19120 (K3754_19065) | 16867..18087 | + | 1221 | WP_259943546.1 | plasmid replication protein RepC | - |
| K3754_RS19125 (K3754_19070) | 18223..18564 | - | 342 | Protein_20 | Fic family protein | - |
Associated MGEs
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MGE detail | Similar MGEs | Relative position | MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | - | 1..72829 | 72829 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 132 a.a. Molecular weight: 14254.24 Da Isoelectric Point: 4.1547
>T212636 WP_259943537.1 NZ_CP081114:c14036-13641 [Sulfitobacter sp. M368]
MSAEFADTNVVLYLLDDGPKADRAEDILGQGPRISVQVLNEAMVNCRRKAGLSWEETGAFLAGVQSLCPVEDLSVQTHLV
GRALAEKYQLSVYDAMIVSAALIAGCTTLWSEDMHDGLLVEDQLRVVNPFT
MSAEFADTNVVLYLLDDGPKADRAEDILGQGPRISVQVLNEAMVNCRRKAGLSWEETGAFLAGVQSLCPVEDLSVQTHLV
GRALAEKYQLSVYDAMIVSAALIAGCTTLWSEDMHDGLLVEDQLRVVNPFT
Download Length: 396 bp
>T212636 NZ_CP107303:c4004903-4004685 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA
Antitoxin
Download Length: 76 a.a. Molecular weight: 8490.74 Da Isoelectric Point: 10.5807
>AT212636 WP_055296342.1 NZ_CP081114:c14253-14026 [Sulfitobacter sp. M368]
MQVAKWGNSLAVRLPADLVRELGLKEGDQIDLIKDDGTLLVQRQPRADEVLQGLRRFRGKLSKDARLSRDAAHER
MQVAKWGNSLAVRLPADLVRELGLKEGDQIDLIKDDGTLLVQRQPRADEVLQGLRRFRGKLSKDARLSRDAAHER
Download Length: 228 bp
>AT212636 NZ_CP107303:c4005304-4004930 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG