Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-MazE
Location 13641..14253 Replicon plasmid unnamed1
Accession NZ_CP081114
Organism Sulfitobacter sp. M368

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag K3754_RS19100 Protein ID WP_259943537.1
Coordinates 13641..14036 (-) Length 132 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag K3754_RS19105 Protein ID WP_055296342.1
Coordinates 14026..14253 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K3754_RS19070 (K3754_19015) 9230..9838 - 609 WP_259943587.1 SMC-Scp complex subunit ScpB -
K3754_RS19075 (K3754_19020) 9853..10812 - 960 WP_259943526.1 DUF1403 family protein -
K3754_RS19080 (K3754_19025) 10938..12035 + 1098 WP_259943528.1 tyrosine-type recombinase/integrase -
K3754_RS19085 (K3754_19030) 12042..12377 - 336 WP_259943531.1 type II toxin-antitoxin system RelE/ParE family toxin -
K3754_RS19090 (K3754_19035) 12374..12631 - 258 WP_259943534.1 type II toxin-antitoxin system ParD family antitoxin -
K3754_RS19095 (K3754_19040) 12767..13579 + 813 WP_259943588.1 recombinase family protein -
K3754_RS19100 (K3754_19045) 13641..14036 - 396 WP_259943537.1 PIN domain-containing protein Toxin
K3754_RS19105 (K3754_19050) 14026..14253 - 228 WP_055296342.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
K3754_RS19110 (K3754_19055) 14490..15677 + 1188 WP_259943540.1 plasmid partitioning protein RepA -
K3754_RS19115 (K3754_19060) 15674..16690 + 1017 WP_259943543.1 plasmid partitioning protein RepB -
K3754_RS19120 (K3754_19065) 16867..18087 + 1221 WP_259943546.1 plasmid replication protein RepC -
K3754_RS19125 (K3754_19070) 18223..18564 - 342 Protein_20 Fic family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..72829 72829


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-113)

Antitoxin

SpoVT-AbrB domain

(5-41)


Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14254.24 Da        Isoelectric Point: 4.1547

>T212636 WP_259943537.1 NZ_CP081114:c14036-13641 [Sulfitobacter sp. M368]
MSAEFADTNVVLYLLDDGPKADRAEDILGQGPRISVQVLNEAMVNCRRKAGLSWEETGAFLAGVQSLCPVEDLSVQTHLV
GRALAEKYQLSVYDAMIVSAALIAGCTTLWSEDMHDGLLVEDQLRVVNPFT

Download         Length: 396 bp

>T212636 NZ_CP107303:c4004903-4004685 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8490.74 Da        Isoelectric Point: 10.5807

>AT212636 WP_055296342.1 NZ_CP081114:c14253-14026 [Sulfitobacter sp. M368]
MQVAKWGNSLAVRLPADLVRELGLKEGDQIDLIKDDGTLLVQRQPRADEVLQGLRRFRGKLSKDARLSRDAAHER

Download         Length: 228 bp

>AT212636 NZ_CP107303:c4005304-4004930 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References