212635

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PP_4151-4152/excise(antitoxin)
Location 2722995..2724031 Replicon chromosome
Accession NZ_CP081113
Organism Sulfitobacter sp. M368

Toxin (Protein)


Gene name PP_4152 Uniprot ID -
Locus tag K3754_RS13680 Protein ID WP_259938030.1
Coordinates 2722995..2723570 (-) Length 192 a.a.

Antitoxin (Protein)


Gene name PP_4151 Uniprot ID -
Locus tag K3754_RS13685 Protein ID WP_231024101.1
Coordinates 2723567..2724031 (-) Length 155 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K3754_RS13645 (K3754_13595) 2718333..2718923 - 591 WP_259938019.1 hypothetical protein -
K3754_RS13650 (K3754_13600) 2719098..2719379 - 282 WP_259938021.1 hypothetical protein -
K3754_RS13655 (K3754_13605) 2719402..2719590 - 189 Protein_2695 hypothetical protein -
K3754_RS13660 (K3754_13610) 2719587..2719790 - 204 WP_259938023.1 hypothetical protein -
K3754_RS13665 (K3754_13615) 2719787..2720095 - 309 WP_259938025.1 hypothetical protein -
K3754_RS13670 (K3754_13620) 2720719..2721597 - 879 WP_259938027.1 zincin-like metallopeptidase domain-containing protein -
K3754_RS13675 (K3754_13625) 2722344..2722940 + 597 WP_259938029.1 DUF6088 family protein -
K3754_RS13680 (K3754_13630) 2722995..2723570 - 576 WP_259938030.1 PIN domain-containing protein Toxin
K3754_RS13685 (K3754_13635) 2723567..2724031 - 465 WP_231024101.1 helix-turn-helix domain-containing protein Antitoxin
K3754_RS13690 (K3754_13640) 2724046..2724222 - 177 WP_259938031.1 hypothetical protein -
K3754_RS13695 (K3754_13645) 2724219..2725082 - 864 WP_259938032.1 hypothetical protein -
K3754_RS13700 (K3754_13650) 2725533..2726114 + 582 WP_259938033.1 hypothetical protein -
K3754_RS13705 (K3754_13655) 2726118..2727155 - 1038 WP_259938035.1 aromatic ring-hydroxylating dioxygenase subunit alpha -
K3754_RS13710 (K3754_13660) 2727347..2729017 - 1671 WP_259938037.1 urocanate hydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 2686187..2725379 39192


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(11-115)

Antitoxin

Helix-turn-helix domain, group 17

(85-133)


Sequences

Toxin        


Download         Length: 192 a.a.        Molecular weight: 21107.07 Da        Isoelectric Point: 4.4140

>T212635 WP_259938030.1 NZ_CP081113:c2723570-2722995 [Sulfitobacter sp. M368]
MSDYADRFTALIDANVLACAMRRNIILSLAEAGFFRPRWSDRIMDETAGAIAKITKGGADTNKQRSAMERAFPEACVTGY
TGLEAGLQLPDPDDRHVLAAAITTSAQVIVTENLKDFPSEALVPFDIDAISADEFISDAIELDSLAAVVALRKMRERFKN
PDMDAEALLQRIKARELFQTAEILHEYVELL

Download         Length: 576 bp

>T212635 NZ_CP107303:3390881-3391414 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGTGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAAGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin


Download         Length: 155 a.a.        Molecular weight: 17136.73 Da        Isoelectric Point: 4.9003

>AT212635 WP_231024101.1 NZ_CP081113:c2724031-2723567 [Sulfitobacter sp. M368]
MMMQAKEAFAERLPDQVEIENADSLRRILASQVNGDEAVELSLALGKKQIEPVTLAPALAASLMELLRLVSSGRGFRMIP
VDAELTTQQAADLLNVSRPHLVKLLEEGEIAFFKTGRHRRVKAADLFEYKKKRDSDRSDALSDLAAMDMENDLL

Download         Length: 465 bp

>AT212635 NZ_CP107303:3390604-3390870 [Klebsiella pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References