Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 18221..18765 Replicon plasmid unnamed1
Accession NZ_CP081110
Organism Sulfitobacter mediterraneus strain M342

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag K3753_RS19220 Protein ID WP_259956306.1
Coordinates 18463..18765 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID -
Locus tag K3753_RS19215 Protein ID WP_259956342.1
Coordinates 18221..18466 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K3753_RS19190 (K3753_19140) 13242..14150 - 909 WP_259956301.1 replication-relaxation family protein -
K3753_RS19195 (K3753_19145) 14169..16268 - 2100 WP_259956302.1 type IV secretory system conjugative DNA transfer family protein -
K3753_RS19200 (K3753_19150) 16268..16627 - 360 WP_259956303.1 hypothetical protein -
K3753_RS19205 (K3753_19155) 16954..17574 - 621 WP_259956304.1 hypothetical protein -
K3753_RS19210 (K3753_19160) 17776..18033 + 258 WP_259956305.1 WGR domain-containing protein -
K3753_RS19215 (K3753_19165) 18221..18466 + 246 WP_259956342.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
K3753_RS19220 (K3753_19170) 18463..18765 + 303 WP_259956306.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K3753_RS19225 19077..19334 - 258 Protein_19 DUF2493 domain-containing protein -
K3753_RS19230 (K3753_19180) 19570..20912 + 1343 WP_259955687.1 IS3 family transposase -
K3753_RS19235 (K3753_19185) 21110..21709 - 600 WP_259956343.1 HAD family phosphatase -
K3753_RS19240 (K3753_19190) 21799..22551 - 753 WP_259956307.1 ATP-binding cassette domain-containing protein -
K3753_RS19245 (K3753_19195) 22583..23530 - 948 WP_259956308.1 substrate-binding domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..136285 136285


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin

Antitoxin ParD

(1-77)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11323.75 Da        Isoelectric Point: 6.8694

>T212634 WP_259956306.1 NZ_CP081110:18463-18765 [Sulfitobacter mediterraneus]
MKPVHLSPAAQADVEDIWDYTETTWGSAQAEKYIGDIQQTCHGVATGRAIVRSAESIRAGYQRSNVGSHVLYFKELEDRF
VIVRILHQKMDVGRYIAERS

Download         Length: 303 bp

>T212634 NZ_CP107303:3288549-3288833 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8891.89 Da        Isoelectric Point: 4.7815

>AT212634 WP_259956342.1 NZ_CP081110:18221-18466 [Sulfitobacter mediterraneus]
MGRNTSVSLGDHFTNFIDERLDTGRYNSASDVVRAGLRLLEEQETQLEALRAALIEGELSGEPAPFDFNGLVARKKSANP
K

Download         Length: 246 bp

>AT212634 NZ_CP107303:3288317-3288559 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References