212633

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PP_4151-4152/excise(antitoxin)
Location 2823680..2824716 Replicon chromosome
Accession NZ_CP081109
Organism Sulfitobacter mediterraneus strain M342

Toxin (Protein)


Gene name PP_4152 Uniprot ID -
Locus tag K3753_RS13930 Protein ID WP_259952858.1
Coordinates 2823680..2824255 (-) Length 192 a.a.

Antitoxin (Protein)


Gene name PP_4151 Uniprot ID -
Locus tag K3753_RS13935 Protein ID WP_259952859.1
Coordinates 2824252..2824716 (-) Length 155 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K3753_RS13895 (K3753_13850) 2818963..2819805 - 843 WP_259952846.1 citryl-CoA lyase -
K3753_RS13900 (K3753_13855) 2819957..2820628 + 672 WP_259952848.1 IclR family transcriptional regulator -
K3753_RS13905 (K3753_13860) 2820656..2820952 + 297 WP_259952850.1 YciI family protein -
K3753_RS13910 (K3753_13865) 2821005..2821427 - 423 WP_259952851.1 Ohr family peroxiredoxin -
K3753_RS13915 (K3753_13870) 2821533..2821955 + 423 WP_259952853.1 MarR family transcriptional regulator -
K3753_RS13920 (K3753_13875) 2822109..2822882 + 774 WP_259952854.1 alpha/beta hydrolase -
K3753_RS13925 (K3753_13880) 2823249..2823488 + 240 WP_259952856.1 helix-turn-helix transcriptional regulator -
K3753_RS13930 (K3753_13885) 2823680..2824255 - 576 WP_259952858.1 PIN domain-containing protein Toxin
K3753_RS13935 (K3753_13890) 2824252..2824716 - 465 WP_259952859.1 helix-turn-helix domain-containing protein Antitoxin
K3753_RS13940 (K3753_13895) 2824984..2825853 - 870 WP_259952861.1 hypothetical protein -
K3753_RS13945 (K3753_13900) 2826584..2826745 - 162 WP_259952862.1 hypothetical protein -
K3753_RS13950 (K3753_13905) 2827168..2828838 - 1671 WP_203198617.1 urocanate hydratase -
K3753_RS13955 (K3753_13910) 2828835..2829629 - 795 WP_259952867.1 N-formylglutamate deformylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(11-115)

Antitoxin

Helix-turn-helix domain, group 17

(85-133)


Sequences

Toxin        


Download         Length: 192 a.a.        Molecular weight: 20999.08 Da        Isoelectric Point: 4.5381

>T212633 WP_259952858.1 NZ_CP081109:c2824255-2823680 [Sulfitobacter mediterraneus]
MSDYADRFTALIDANVLACAMRRNIILSLAEAGLFRPRWSDRIMDETAGAIAKITKGGADTIKQRSAMERAFPEACVTGY
AGLEAGLELPDPDDRHVLAAAITTSAQVIVTENLKDFPSEALAPFDIDAISADEFISDAIELDPLAAVAALRKMRERFKN
PDMDAEALLQRIKARKLFQTAETLHQFMELL

Download         Length: 576 bp

>T212633 NZ_CP107303:3131733-3132650 [Klebsiella pneumoniae]
ATGGATATACAGGCGCCTTATTATCGGCAGGTTGCTCTGCTAATGCAGGTTTTACCCTATGTTGCTGTCGAACGGGAATT
TGCGCTGAAAGGTGGCACTGCCATCAATCTCTTTATCCGCGATTTCCCTCGATTATCGGTGGATATCGACCTCGCCTGGG
TGCCCCTGGAAAGCAGAGCCATCGCTTTACCTCATATACGGGATGCGCTTGCACGTATTGCCGCCAATCTGCAACAACAG
GCAGGTATGAGCGCTGTATTACAAGCTAATCGTTCAGATGAGATGCGTGTCATTGTTACTACCGATAGCGCGCAAATAAA
GATAGAGGTTTCACCGGTCGCCCGGGGAACATTATATCCACCACAGGAGCGAGAAGTGGTGGGGGCGGTAGAGGACGTTT
TTGGCTATGCCAGCCTTCCAGTGGTTTCGTTGCCTGACCTCTACGGTGGAAAATTATGCGCGGCGCTGGATCGCCAGCAT
CCCAGAGATTTTTATGACGTGAAATTACTTCTTGATGCGCAGGAGCTTGACCGTCCCATTTTCAATGGGTTTATCGTGTA
TTTACTGAGCCATAATCGGCCTCTGGCTGAAGTGCTGAATCCTCGCTGGAAAGATATTGCTGAACCTTTTTACCGTGAAT
TCAGCGGGATGACATTTGAGACGATAGCCCTGGAGGAACTGACAGCAGTCCCCAACAGGATGATTGCTGCGTTAAAATCC
TGTTTCACACAACAGGATGTCGATTTTTTACTGTCATTTAAACGAGGCGAACCAGACTGGCGTTTAGCGCCGGAAATGCG
TATTCAGGATTTGCCTGCCGTGCAGTGGAAATTGCGCAATATTCATCAGATGCCAGCGATAAAACGCGCTGAGTCATTAG
ATAAACTGGAAAAGGTGCTGGCCGAGTGGCGCAGTTAG

Antitoxin


Download         Length: 155 a.a.        Molecular weight: 17112.62 Da        Isoelectric Point: 4.6526

>AT212633 WP_259952859.1 NZ_CP081109:c2824716-2824252 [Sulfitobacter mediterraneus]
MMMQAKEAFAERLPDQVEIENADSLRRILASQVNGDEAVELSLALGEKQIEPVTLAPALAASLMELLRLVSSGRGFRMIP
VDAELTTQQAADLLNVSRPHLVKLLEDGDIAFYKTGRHRRVKAADLFEYKKKRDTDRSDALSDLAAMDMESDLL

Download         Length: 465 bp

>AT212633 NZ_CP107303:3130969-3131727 [Klebsiella pneumoniae]
ATGGCAACAAAATTAAACTGGCTGCTGCAAAACAGCGCTCCCGGAGATGTGATCCTTCAGTCCTGGTTAAGCCAGCATGC
CATCTCTCCCTCTCTGTCCTTTAAATACGCGCAAAGTGGCTGGTTAAAAAAAAGAGGCAACGGCGTATATGCGCGTGCGG
GACGTGAGCCGGAGTGGAACGATGCATTAGCATGTTTGCAAAATCAGCTTGCCGCTCCGGTGTATGTTGCGGGGCTCAGT
AGCTTAGTCTGGCAGGGCCGTTCACACTATCTACAGCTAAAACAAAACCAGTGCTGGCTTAGTGTGGAAAATAAAGCGCT
GCTGCCGAAATGGTTCAGGGAATTCCCGGGTGTGGAGTGGATAGTCATATCGGGGAAAAAACTGCCGGTGCTGGATGATA
GATACCGTGTAACGCTTGATATAAAAGGGAAAAAACTCATCGGCAGTGCGCCAGAACTGGCTGCTTACGAGTTGCTGAGC
GCGGTGCCGGGGACCCTCTCATTTAACCACGCTGCAGAGCTTTTCCAGGGGCTGGTTAATCTTAATCCTCGTAAAGTAGA
GTATCTTCTTTCCGTCAGCCAGTCCGTGCAGGCCAAGCGTTTGTATCTCTTCTTCGCCAGTTTTTACGAGCATGGCTGGC
TCAAACGAATCGATAGCCAAAAAATCGATCTGGGAGCGGGCAAGCGGCAAATCGTGGAAAATGGAAAGTTCAATGCTCAA
TACCAAATCACAGTGCCTGAACGCTTTCAAAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References