Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | parDE/ParE-CC2985 |
| Location | 25408..25939 | Replicon | plasmid unnamed2 |
| Accession | NZ_CP081060 | ||
| Organism | Leisingera aquaemixtae strain M602 | ||
Toxin (Protein)
| Gene name | parE | Uniprot ID | - |
| Locus tag | K3719_RS19430 | Protein ID | WP_259947435.1 |
| Coordinates | 25637..25939 (+) | Length | 101 a.a. |
Antitoxin (Protein)
| Gene name | parD | Uniprot ID | - |
| Locus tag | K3719_RS19425 | Protein ID | WP_259947433.1 |
| Coordinates | 25408..25644 (+) | Length | 79 a.a. |
Genomic Context
Location: 21406..25263 (3858 bp)
Type: Others
Protein ID: WP_259947470.1
Type: Others
Protein ID: WP_259947470.1
Location: 25408..25644 (237 bp)
Type: Antitoxin
Protein ID: WP_259947433.1
Type: Antitoxin
Protein ID: WP_259947433.1
Location: 25637..25939 (303 bp)
Type: Toxin
Protein ID: WP_259947435.1
Type: Toxin
Protein ID: WP_259947435.1
Location: 25989..26900 (912 bp)
Type: Others
Protein ID: WP_259947437.1
Type: Others
Protein ID: WP_259947437.1
Location: 26910..27344 (435 bp)
Type: Others
Protein ID: WP_259947439.1
Type: Others
Protein ID: WP_259947439.1
Location: 27411..28685 (1275 bp)
Type: Others
Protein ID: WP_259947441.1
Type: Others
Protein ID: WP_259947441.1
Location: 28791..29474 (684 bp)
Type: Others
Protein ID: WP_141892205.1
Type: Others
Protein ID: WP_141892205.1
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Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| K3719_RS19420 (K3719_19350) | 21406..25263 | + | 3858 | WP_259947470.1 | PEP/pyruvate-binding domain-containing protein | - |
| K3719_RS19425 (K3719_19355) | 25408..25644 | + | 237 | WP_259947433.1 | type II toxin-antitoxin system ParD family antitoxin | Antitoxin |
| K3719_RS19430 (K3719_19360) | 25637..25939 | + | 303 | WP_259947435.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| K3719_RS19435 (K3719_19365) | 25989..26900 | + | 912 | WP_259947437.1 | MurR/RpiR family transcriptional regulator | - |
| K3719_RS19440 (K3719_19370) | 26910..27344 | - | 435 | WP_259947439.1 | GFA family protein | - |
| K3719_RS19445 (K3719_19375) | 27411..28685 | - | 1275 | WP_259947441.1 | nucleotide sugar dehydrogenase | - |
| K3719_RS19450 (K3719_19380) | 28791..29474 | - | 684 | WP_141892205.1 | hypothetical protein | - |
Associated MGEs
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MGE detail | Similar MGEs | Relative position | MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | hsiB1/vipA / hsiC1/vipB / clpV1 | 1..108687 | 108687 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 101 a.a. Molecular weight: 11490.16 Da Isoelectric Point: 6.7263
>T212630 WP_259947435.1 NZ_CP081060:25637-25939 [Leisingera aquaemixtae]
MAEPRWRIRPAARADLAAIWRYGRDTWGAAQADAYADSLFALFDVLADFPEMARERAEFTPPVRIHPSGAHLVLYRLEQG
RPEILRILHARQDLMAFLSE
MAEPRWRIRPAARADLAAIWRYGRDTWGAAQADAYADSLFALFDVLADFPEMARERAEFTPPVRIHPSGAHLVLYRLEQG
RPEILRILHARQDLMAFLSE
Download Length: 303 bp
>T212630 NZ_CP107303:c2375151-2374804 [Klebsiella pneumoniae]
ATGTGGGATGTAGAAACGACGGATACGTTTGATGCCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCCTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTGCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTGTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGTGGGCAATAAGGATGGCATGAATGAGAAACGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA
ATGTGGGATGTAGAAACGACGGATACGTTTGATGCCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCCTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTGCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTGTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGTGGGCAATAAGGATGGCATGAATGAGAAACGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA
Antitoxin
Download Length: 79 a.a. Molecular weight: 8488.46 Da Isoelectric Point: 4.6721
>AT212630 WP_259947433.1 NZ_CP081060:25408-25644 [Leisingera aquaemixtae]
MATMNVSLPDQMKDWVEEQARTGTYANSSDYVRDLIRRDQARTAAIAELQTAIDAGIASGPAEPLSAESFKAAMRRNG
MATMNVSLPDQMKDWVEEQARTGTYANSSDYVRDLIRRDQARTAAIAELQTAIDAGIASGPAEPLSAESFKAAMRRNG
Download Length: 237 bp
>AT212630 NZ_CP107303:c2374804-2374505 [Klebsiella pneumoniae]
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGATAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGGCTGATAACGACCCTCGGCTTTCGACCCTAAAACGCTACATTGCGGCATTGGGG
GGAGAACTCAGTATAAATGTCACATTGCCGACTGGAAAAAAAGTCTCGTTTAATTTGTGA
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGATAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGGCTGATAACGACCCTCGGCTTTCGACCCTAAAACGCTACATTGCGGCATTGGGG
GGAGAACTCAGTATAAATGTCACATTGCCGACTGGAAAAAAAGTCTCGTTTAATTTGTGA