Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | parDE/CC2985(antitoxin) |
| Location | 38491..39022 | Replicon | plasmid unnamed3 |
| Accession | NZ_CP081047 | ||
| Organism | Leisingera aquaemixtae strain M597 | ||
Toxin (Protein)
| Gene name | parE | Uniprot ID | - |
| Locus tag | K3552_RS19255 | Protein ID | WP_260014085.1 |
| Coordinates | 38491..38793 (-) | Length | 101 a.a. |
Antitoxin (Protein)
| Gene name | parD | Uniprot ID | - |
| Locus tag | K3552_RS19260 | Protein ID | WP_260014087.1 |
| Coordinates | 38786..39022 (-) | Length | 79 a.a. |
Genomic Context
Location: 34955..35638 (684 bp)
Type: Others
Protein ID: WP_260014080.1
Type: Others
Protein ID: WP_260014080.1
Location: 35744..37018 (1275 bp)
Type: Others
Protein ID: WP_260014081.1
Type: Others
Protein ID: WP_260014081.1
Location: 37086..37520 (435 bp)
Type: Others
Protein ID: WP_260014082.1
Type: Others
Protein ID: WP_260014082.1
Location: 37530..38441 (912 bp)
Type: Others
Protein ID: WP_260014084.1
Type: Others
Protein ID: WP_260014084.1
Location: 38491..38793 (303 bp)
Type: Toxin
Protein ID: WP_260014085.1
Type: Toxin
Protein ID: WP_260014085.1
Location: 38786..39022 (237 bp)
Type: Antitoxin
Protein ID: WP_260014087.1
Type: Antitoxin
Protein ID: WP_260014087.1
Location: 39167..43024 (3858 bp)
Type: Others
Protein ID: WP_260014153.1
Type: Others
Protein ID: WP_260014153.1
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Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| K3552_RS19235 (K3552_19190) | 34955..35638 | + | 684 | WP_260014080.1 | hypothetical protein | - |
| K3552_RS19240 (K3552_19195) | 35744..37018 | + | 1275 | WP_260014081.1 | Vi polysaccharide biosynthesis UDP-N-acetylglucosamine C-6 dehydrogenase TviB | - |
| K3552_RS19245 (K3552_19200) | 37086..37520 | + | 435 | WP_260014082.1 | GFA family protein | - |
| K3552_RS19250 (K3552_19205) | 37530..38441 | - | 912 | WP_260014084.1 | MurR/RpiR family transcriptional regulator | - |
| K3552_RS19255 (K3552_19210) | 38491..38793 | - | 303 | WP_260014085.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| K3552_RS19260 (K3552_19215) | 38786..39022 | - | 237 | WP_260014087.1 | type II toxin-antitoxin system ParD family antitoxin | Antitoxin |
| K3552_RS19265 (K3552_19220) | 39167..43024 | - | 3858 | WP_260014153.1 | PEP/pyruvate-binding domain-containing protein | - |
Associated MGEs
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MGE detail | Similar MGEs | Relative position | MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | clpV1 / hsiC1/vipB / hsiB1/vipA | 1..108896 | 108896 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 101 a.a. Molecular weight: 11543.22 Da Isoelectric Point: 6.8804
>T212629 WP_260014085.1 NZ_CP081047:c38793-38491 [Leisingera aquaemixtae]
MAEPRWRIRPAARADLAAIWRYGRDTWGAAQADAYTDSLFALFDLLADFPEMARERAEFTPPVRIHPSGAHLVLYRLEHG
RPEILRILHARQDLMAFLSE
MAEPRWRIRPAARADLAAIWRYGRDTWGAAQADAYTDSLFALFDLLADFPEMARERAEFTPPVRIHPSGAHLVLYRLEHG
RPEILRILHARQDLMAFLSE
Download Length: 303 bp
>T212629 NZ_CP107303:c1851973-1851566 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCGTGC
GCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCCGAA
TGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGGACA
GCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGGCGC
AGGAGTAA
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCGTGC
GCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCCGAA
TGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGGACA
GCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGGCGC
AGGAGTAA
Antitoxin
Download Length: 79 a.a. Molecular weight: 8474.43 Da Isoelectric Point: 4.6721
>AT212629 WP_260014087.1 NZ_CP081047:c39022-38786 [Leisingera aquaemixtae]
MATMNVSLPDQMKDWVEEQARTGTYANSSDYVRDLIRRDQARTAAIAELQSAIDAGLASGPAEPLSAESFKAAMRRNG
MATMNVSLPDQMKDWVEEQARTGTYANSSDYVRDLIRRDQARTAAIAELQSAIDAGLASGPAEPLSAESFKAAMRRNG
Download Length: 237 bp
>AT212629 NZ_CP107303:c1852220-1851954 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA