Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB(antitoxin)
Location 4549976..4550604 Replicon chromosome
Accession NZ_CP081016
Organism Pseudomonas sp. 2hn

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag K2O50_RS20590 Protein ID WP_050704039.1
Coordinates 4550422..4550604 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag K2O50_RS20585 Protein ID WP_050704040.1
Coordinates 4549976..4550401 (-) Length 142 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K2O50_RS20560 (K2O50_20560) 4545602..4546096 + 495 WP_028690059.1 DUF6231 family protein -
K2O50_RS20565 (K2O50_20565) 4546101..4546577 + 477 WP_050704043.1 YchJ family protein -
K2O50_RS20570 (K2O50_20570) 4546580..4547056 + 477 WP_050704042.1 LEA type 2 family protein -
K2O50_RS20575 (K2O50_20575) 4547064..4547267 + 204 WP_012313055.1 SEC-C metal-binding domain-containing protein -
K2O50_RS20580 (K2O50_20580) 4547461..4549896 + 2436 WP_050704041.1 penicillin acylase family protein -
K2O50_RS20585 (K2O50_20585) 4549976..4550401 - 426 WP_050704040.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
K2O50_RS20590 (K2O50_20590) 4550422..4550604 - 183 WP_050704039.1 type II toxin-antitoxin system HicA family toxin Toxin
K2O50_RS20595 (K2O50_20595) 4550837..4551952 + 1116 WP_050704038.1 M14 family metallopeptidase -
K2O50_RS20600 (K2O50_20600) 4551959..4552201 - 243 WP_050704037.1 hypothetical protein -
K2O50_RS20605 (K2O50_20605) 4552295..4552861 - 567 WP_050704036.1 dCTP deaminase -
K2O50_RS20610 (K2O50_20610) 4553190..4553399 + 210 WP_003254922.1 cold-shock protein -
K2O50_RS20615 (K2O50_20615) 4553622..4554716 - 1095 WP_050704035.1 iron-sulfur cluster carrier protein ApbC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-58)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(5-69)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6934.06 Da        Isoelectric Point: 10.7425

>T212592 WP_050704039.1 NZ_CP081016:c4550604-4550422 [Pseudomonas sp. 2hn]
MKYSELRRWLRSQGATFVPAKGSHFKVYLGDRQTIFPDHGAKEMGEGLRKKILKDLGLRD

Download         Length: 183 bp

>T212592 NZ_CP107291:329445-329813 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCAGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACTCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCGGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCGGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGCTTGCGCGGATGA

Antitoxin


Download         Length: 142 a.a.        Molecular weight: 15407.70 Da        Isoelectric Point: 5.1630

>AT212592 WP_050704040.1 NZ_CP081016:c4550401-4549976 [Pseudomonas sp. 2hn]
MNFDYPVNVHRDAGSVWISCPDIPEMASAGDTLDEALFDAVDALESALSLYVDRRVAIPLPSSLQSAEAVVRLPALTAAK
AALWNTMIAQNVTKTEMARRLGVNRPQVDRLVDLLHRSKIEQVEHALHVLGQRIELAVVAA

Download         Length: 426 bp

>AT212592 NZ_CP107291:329227-329448 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGACGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References