Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | hicAB/HicB(antitoxin) |
Location | 4549976..4550604 | Replicon | chromosome |
Accession | NZ_CP081016 | ||
Organism | Pseudomonas sp. 2hn |
Toxin (Protein)
Gene name | hicA | Uniprot ID | - |
Locus tag | K2O50_RS20590 | Protein ID | WP_050704039.1 |
Coordinates | 4550422..4550604 (-) | Length | 61 a.a. |
Antitoxin (Protein)
Gene name | hicB | Uniprot ID | - |
Locus tag | K2O50_RS20585 | Protein ID | WP_050704040.1 |
Coordinates | 4549976..4550401 (-) | Length | 142 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
K2O50_RS20560 (K2O50_20560) | 4545602..4546096 | + | 495 | WP_028690059.1 | DUF6231 family protein | - |
K2O50_RS20565 (K2O50_20565) | 4546101..4546577 | + | 477 | WP_050704043.1 | YchJ family protein | - |
K2O50_RS20570 (K2O50_20570) | 4546580..4547056 | + | 477 | WP_050704042.1 | LEA type 2 family protein | - |
K2O50_RS20575 (K2O50_20575) | 4547064..4547267 | + | 204 | WP_012313055.1 | SEC-C metal-binding domain-containing protein | - |
K2O50_RS20580 (K2O50_20580) | 4547461..4549896 | + | 2436 | WP_050704041.1 | penicillin acylase family protein | - |
K2O50_RS20585 (K2O50_20585) | 4549976..4550401 | - | 426 | WP_050704040.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
K2O50_RS20590 (K2O50_20590) | 4550422..4550604 | - | 183 | WP_050704039.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
K2O50_RS20595 (K2O50_20595) | 4550837..4551952 | + | 1116 | WP_050704038.1 | M14 family metallopeptidase | - |
K2O50_RS20600 (K2O50_20600) | 4551959..4552201 | - | 243 | WP_050704037.1 | hypothetical protein | - |
K2O50_RS20605 (K2O50_20605) | 4552295..4552861 | - | 567 | WP_050704036.1 | dCTP deaminase | - |
K2O50_RS20610 (K2O50_20610) | 4553190..4553399 | + | 210 | WP_003254922.1 | cold-shock protein | - |
K2O50_RS20615 (K2O50_20615) | 4553622..4554716 | - | 1095 | WP_050704035.1 | iron-sulfur cluster carrier protein ApbC | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 61 a.a. Molecular weight: 6934.06 Da Isoelectric Point: 10.7425
>T212592 WP_050704039.1 NZ_CP081016:c4550604-4550422 [Pseudomonas sp. 2hn]
MKYSELRRWLRSQGATFVPAKGSHFKVYLGDRQTIFPDHGAKEMGEGLRKKILKDLGLRD
MKYSELRRWLRSQGATFVPAKGSHFKVYLGDRQTIFPDHGAKEMGEGLRKKILKDLGLRD
Download Length: 183 bp
>T212592 NZ_CP107291:329445-329813 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCAGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACTCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCGGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCGGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGCTTGCGCGGATGA
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCAGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACTCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCGGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCGGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGCTTGCGCGGATGA
Antitoxin
Download Length: 142 a.a. Molecular weight: 15407.70 Da Isoelectric Point: 5.1630
>AT212592 WP_050704040.1 NZ_CP081016:c4550401-4549976 [Pseudomonas sp. 2hn]
MNFDYPVNVHRDAGSVWISCPDIPEMASAGDTLDEALFDAVDALESALSLYVDRRVAIPLPSSLQSAEAVVRLPALTAAK
AALWNTMIAQNVTKTEMARRLGVNRPQVDRLVDLLHRSKIEQVEHALHVLGQRIELAVVAA
MNFDYPVNVHRDAGSVWISCPDIPEMASAGDTLDEALFDAVDALESALSLYVDRRVAIPLPSSLQSAEAVVRLPALTAAK
AALWNTMIAQNVTKTEMARRLGVNRPQVDRLVDLLHRSKIEQVEHALHVLGQRIELAVVAA
Download Length: 426 bp
>AT212592 NZ_CP107291:329227-329448 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGACGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGACGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
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Antitoxin
Source | ID | Structure |
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