Detailed information of TA system TA212590

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 3533745..3534261
• Replicon: chromosome
• Accession: NZ_CP081016
• Organism: Pseudomonas sp. 2hn

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: K2O50_RS15725
• Protein ID: WP_050705241.1
• Coordinates: 3533745..3534026 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A246GY67
• Locus tag: K2O50_RS15730
• Protein ID: WP_050705246.1
• Coordinates: 3534016..3534261 (-)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K2O50_RS15705 (K2O50_15705)	3529208..3530617	-	1410	WP_050705243.1	amino acid permease	-
K2O50_RS15710 (K2O50_15710)	3531056..3532480	+	1425	WP_050705242.1	PLP-dependent aminotransferase family protein	-
K2O50_RS15715 (K2O50_15715)	3532596..3532946	-	351	WP_162232962.1	EF-hand domain-containing protein	-
K2O50_RS15720 (K2O50_15720)	3533105..3533693	-	589	Protein_3114	histone deacetylase family protein	-
K2O50_RS15725 (K2O50_15725)	3533745..3534026	-	282	WP_050705241.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
K2O50_RS15730 (K2O50_15730)	3534016..3534261	-	246	WP_050705246.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
K2O50_RS15735 (K2O50_15735)	3534327..3535067	-	741	WP_050705240.1	hypothetical protein	-
K2O50_RS15740 (K2O50_15740)	3535335..3536081	-	747	WP_220689831.1	sulfite exporter TauE/SafE family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-83)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (9-77)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10980.87 Da
• Isoelectric Point: 11.0508

>T212590 WP_050705241.1 NZ_CP081016:c3534026-3533745 [Pseudomonas sp. 2hn]
MTYRLEFLPSALKEWEKLGHTVREQARKKLRQRLLSPKVGVDALRDLPNHYKIKLRASGYRLVYRVEDDRVVVVVVAIGK
RERGQAYRSAYIR

Nucleotide

• Length: 282 bp

>T212590 NZ_CP107288:2257-2535 [Escherichia coli]
ATGGAGATATTCTGGACCATGCTGGCCAGCCAGGACAGGAAGCGCATTCGTGAGTACATTGCGGAGCAGAACCTGATGGC
CGCCATTGAACTGGACGAACGGATTGGTTATTCAGCCAGCAGCCTGGCCGGGCAGCCGTATAAAGGTCGCAACGGTCGTG
TGGAAGGAACCCGGGAACTGGTTATTCACCCCCATTTTGTTCTGGTTTATGAGGTCGACAGCCAGTGGGGAAAAGTGTAT
GTCCTGCGCGTGTTGCATACCGCACAGAAGTGGCCATAA

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 8885.36 Da
• Isoelectric Point: 4.4000

>AT212590 WP_050705246.1 NZ_CP081016:c3534261-3534016 [Pseudomonas sp. 2hn]
MQNIFADVTVSVSELKKNPTAVMADAQGKPVAVLNHNRVMGYMVPAELYEAMMERLEDIELVALVKARAGEKGIPVELDD
L

Nucleotide

• Length: 246 bp

>AT212590 NZ_CP107288:1988-2257 [Escherichia coli]
ATGGCACAGGTTAATATGAGTTTAAGAATCGACGCTGAACTGAAGGATGCTTTTATGGCCGCTGCAAAAAGCATGGACCG
TAATGGCTCTCAGTTAATTCGGGATTTTATGCGCCAGACCGTTGAACGGCAGCATAATACCTGGTTCCGTGACCAGGTTG
CGGCAGGACGTCAGCAACTCGAGCGCGGCGATGTGCTTCCCCATGACATGGTCGAATCTTCTGCCGCTGCATGGCGGGAT
GAAATGAGCAGGAAGGTTTCCGATAAATGA

Structures

Antitoxin

• AlphaFold DB: A0A246GY67