Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumA-relB/upstrm_HI1419-dnstrm_HI1420
Location 316365..316970 Replicon chromosome
Accession NZ_CP081016
Organism Pseudomonas sp. 2hn

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag K2O50_RS01505 Protein ID WP_050703403.1
Coordinates 316365..316655 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag K2O50_RS01510 Protein ID WP_050703404.1
Coordinates 316665..316970 (+) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K2O50_RS01485 (K2O50_01485) 311715..312488 - 774 WP_050703399.1 ABC transporter ATP-binding protein -
K2O50_RS01490 (K2O50_01490) 313095..314480 + 1386 WP_050703400.1 GABA permease -
K2O50_RS01495 (K2O50_01495) 314555..314998 - 444 WP_050703401.1 hypothetical protein -
K2O50_RS01500 (K2O50_01500) 315191..316201 - 1011 WP_050703402.1 polyphosphate kinase 2 -
K2O50_RS01505 (K2O50_01505) 316365..316655 + 291 WP_050703403.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K2O50_RS01510 (K2O50_01510) 316665..316970 + 306 WP_050703404.1 putative addiction module antidote protein Antitoxin
K2O50_RS01520 (K2O50_01520) 317242..317514 - 273 WP_011536185.1 oxidative damage protection protein -
K2O50_RS01525 (K2O50_01525) 317511..318578 - 1068 WP_050703405.1 A/G-specific adenine glycosylase -
K2O50_RS01530 (K2O50_01530) 318575..320824 - 2250 WP_050703406.1 AsmA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-96)

Antitoxin

Cro/C1-type helix-turn-helix domain

(48-90)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 10946.80 Da        Isoelectric Point: 10.7046

>T212584 WP_050703403.1 NZ_CP081016:316365-316655 [Pseudomonas sp. 2hn]
MHTLIQTDMYRKWFAALRDARAQARINVRLRRVELGVLGDCKPVGEGVFELRIDYGPGYRVYLARRGYEVIILLAGGDKA
TQARDIKSALRLARNL

Download         Length: 291 bp

>T212584 NZ_CP107284:c4413290-4413000 [Escherichia coli]
ATGAACTATGAGCTGGCGTTTGATCCGCGGGCGCTGAAAGAGTGGCAAAAACTGGGCGTGACAGTCCGGGAACAATTTAA
AAAAAAGCTTGAGGATGTGCTGAAAAGGCCGCGCAATCCATCGGCTAAACTGCGGGATTTACCGGACTGCTACAAAATTA
AGCTGCGCACACAGGGATATCGCCTGGTTTATCAGGTTAACGATAAAGAGTTGCTCGTGTTGGTGATAGCTATTGGTAAG
AGAGAGAACTCAGCCGTTTATGAAGACGCGACTAAACGGCTGGATGAGTGA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 10804.43 Da        Isoelectric Point: 4.6135

>AT212584 WP_050703404.1 NZ_CP081016:316665-316970 [Pseudomonas sp. 2hn]
MTDLKLTKWDAADHLQTEEDIVLYLEACLEENDPTLLAAALGDIARARGMAQLARDTGLTREGLYKALSADGNPSLATIM
KVMAALGVRLHAEIVTPRAAG

Download         Length: 306 bp

>AT212584 NZ_CP107284:c4413522-4413280 [Escherichia coli]
ATGGCCACACTTAACGTCCGCCTGGATGACAAACTGAAAAATGAGGCTTATGCGGTGCTGGAAAAATTAAATATCACGCC
TACTGAAGCAGTGCGACTGCTGTTTCAGTACGTTGCGGAAAATGGACGAATGCCGGTAAAAACGCTCACTGTCAGTGATA
GTGAAGAAGCCTTGTTACGCACTGTCAGGGAACGACTGGCCAACCCACAAGAGGCCATTAAGGTCCGACTGGATGAACTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References