Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hicAB/HicA-HicB |
| Location | 301355..301977 | Replicon | chromosome |
| Accession | NZ_CP081016 | ||
| Organism | Pseudomonas sp. 2hn | ||
Toxin (Protein)
| Gene name | hicA | Uniprot ID | - |
| Locus tag | K2O50_RS01400 | Protein ID | WP_050703388.1 |
| Coordinates | 301355..301546 (+) | Length | 64 a.a. |
Antitoxin (Protein)
| Gene name | hicB | Uniprot ID | A0A8H9Z3K8 |
| Locus tag | K2O50_RS01405 | Protein ID | WP_050703389.1 |
| Coordinates | 301564..301977 (+) | Length | 138 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| K2O50_RS01380 (K2O50_01380) | 297209..297727 | + | 519 | WP_050703384.1 | dihydrofolate reductase | - |
| K2O50_RS01385 (K2O50_01385) | 297865..299256 | - | 1392 | WP_050703385.1 | L-cystine transporter | - |
| K2O50_RS01390 (K2O50_01390) | 299504..300559 | + | 1056 | WP_198742370.1 | haloacid dehalogenase-like hydrolase | - |
| K2O50_RS01395 (K2O50_01395) | 300633..301178 | + | 546 | WP_050703387.1 | HDIG domain-containing protein | - |
| K2O50_RS01400 (K2O50_01400) | 301355..301546 | + | 192 | WP_050703388.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
| K2O50_RS01405 (K2O50_01405) | 301564..301977 | + | 414 | WP_050703389.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
| K2O50_RS01410 (K2O50_01410) | 302090..302341 | + | 252 | WP_050703390.1 | helix-turn-helix domain-containing protein | - |
| K2O50_RS01415 (K2O50_01415) | 302341..303531 | + | 1191 | WP_050703424.1 | HipA domain-containing protein | - |
| K2O50_RS01420 (K2O50_01420) | 303512..303721 | - | 210 | WP_050703391.1 | DUF3079 domain-containing protein | - |
| K2O50_RS01425 (K2O50_01425) | 303799..304944 | - | 1146 | WP_050703392.1 | copper-containing nitrite reductase | - |
| K2O50_RS01435 (K2O50_01435) | 305274..305525 | - | 252 | WP_052896382.1 | hypothetical protein | - |
| K2O50_RS01440 (K2O50_01440) | 305548..305934 | - | 387 | WP_050703393.1 | hypothetical protein | - |
| K2O50_RS01445 (K2O50_01445) | 305953..306159 | - | 207 | WP_023629980.1 | helix-turn-helix transcriptional regulator | - |
| K2O50_RS01450 (K2O50_01450) | 306169..306747 | - | 579 | WP_050703394.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 64 a.a. Molecular weight: 7045.16 Da Isoelectric Point: 10.4613
>T212583 WP_050703388.1 NZ_CP081016:301355-301546 [Pseudomonas sp. 2hn]
MNSREMISVIEADGWYLVRSKGSHHHFKHPEKPGLVTIPHPKKDLLPATAASILRQARIGYAS
MNSREMISVIEADGWYLVRSKGSHHHFKHPEKPGLVTIPHPKKDLLPATAASILRQARIGYAS
Download Length: 192 bp
>T212583 NZ_CP107284:4308652-4308909 [Escherichia coli]
ATGAATTTATCCCGTCAGGAACAACATACCTTACACGTTCTCGCTAAAGGTAGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGCCAGCCCTATCGAATCAACACCACCGAGCTGAATAAAGTTCGCGCT
CAGCTCGATAATCGCTAA
ATGAATTTATCCCGTCAGGAACAACATACCTTACACGTTCTCGCTAAAGGTAGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGCCAGCCCTATCGAATCAACACCACCGAGCTGAATAAAGTTCGCGCT
CAGCTCGATAATCGCTAA
Antitoxin
Download Length: 138 a.a. Molecular weight: 14950.03 Da Isoelectric Point: 4.5801
>AT212583 WP_050703389.1 NZ_CP081016:301564-301977 [Pseudomonas sp. 2hn]
MLFPIAILPGDDQHAWGVEVPDIPGCFSAGEDLDNAIAMAREAIEGHLELLAQDQQEIPKASLVSVHAANPSYAGCTWAL
IDIDITRYLGKAEKLNITLPAYLLTRIDSYVQNHPEHKSRSGFLAEAALRILQGDCK
MLFPIAILPGDDQHAWGVEVPDIPGCFSAGEDLDNAIAMAREAIEGHLELLAQDQQEIPKASLVSVHAANPSYAGCTWAL
IDIDITRYLGKAEKLNITLPAYLLTRIDSYVQNHPEHKSRSGFLAEAALRILQGDCK
Download Length: 414 bp
>AT212583 NZ_CP107284:4308921-4309466 [Escherichia coli]
ATGACAGTACACCACTTCACTTTTCATATCACAGATAAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCAGCAAAGAAGCCGATTTAGTGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCCGCGTTATCGCTGCTAGCCC
GGTATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCAACCTTCAAAGGAGAAATGGATTCACCGTTGATGCAC
ATCCTCGCTCCCCTGGCGGTCATACCGGAATACCAAGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAATCACTCACCGCT
CAGCCCATGACCCTGACCGGCCACATCCGGTGCGCAGACCCTGATGAAACCGGAGCACTGACGTGA
ATGACAGTACACCACTTCACTTTTCATATCACAGATAAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCAGCAAAGAAGCCGATTTAGTGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCCGCGTTATCGCTGCTAGCCC
GGTATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCAACCTTCAAAGGAGAAATGGATTCACCGTTGATGCAC
ATCCTCGCTCCCCTGGCGGTCATACCGGAATACCAAGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAATCACTCACCGCT
CAGCCCATGACCCTGACCGGCCACATCCGGTGCGCAGACCCTGATGAAACCGGAGCACTGACGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|