Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 301355..301977 Replicon chromosome
Accession NZ_CP081016
Organism Pseudomonas sp. 2hn

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag K2O50_RS01400 Protein ID WP_050703388.1
Coordinates 301355..301546 (+) Length 64 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A8H9Z3K8
Locus tag K2O50_RS01405 Protein ID WP_050703389.1
Coordinates 301564..301977 (+) Length 138 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K2O50_RS01380 (K2O50_01380) 297209..297727 + 519 WP_050703384.1 dihydrofolate reductase -
K2O50_RS01385 (K2O50_01385) 297865..299256 - 1392 WP_050703385.1 L-cystine transporter -
K2O50_RS01390 (K2O50_01390) 299504..300559 + 1056 WP_198742370.1 haloacid dehalogenase-like hydrolase -
K2O50_RS01395 (K2O50_01395) 300633..301178 + 546 WP_050703387.1 HDIG domain-containing protein -
K2O50_RS01400 (K2O50_01400) 301355..301546 + 192 WP_050703388.1 type II toxin-antitoxin system HicA family toxin Toxin
K2O50_RS01405 (K2O50_01405) 301564..301977 + 414 WP_050703389.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
K2O50_RS01410 (K2O50_01410) 302090..302341 + 252 WP_050703390.1 helix-turn-helix domain-containing protein -
K2O50_RS01415 (K2O50_01415) 302341..303531 + 1191 WP_050703424.1 HipA domain-containing protein -
K2O50_RS01420 (K2O50_01420) 303512..303721 - 210 WP_050703391.1 DUF3079 domain-containing protein -
K2O50_RS01425 (K2O50_01425) 303799..304944 - 1146 WP_050703392.1 copper-containing nitrite reductase -
K2O50_RS01435 (K2O50_01435) 305274..305525 - 252 WP_052896382.1 hypothetical protein -
K2O50_RS01440 (K2O50_01440) 305548..305934 - 387 WP_050703393.1 hypothetical protein -
K2O50_RS01445 (K2O50_01445) 305953..306159 - 207 WP_023629980.1 helix-turn-helix transcriptional regulator -
K2O50_RS01450 (K2O50_01450) 306169..306747 - 579 WP_050703394.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-58)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-128)


Sequences

Toxin        


Download         Length: 64 a.a.        Molecular weight: 7045.16 Da        Isoelectric Point: 10.4613

>T212583 WP_050703388.1 NZ_CP081016:301355-301546 [Pseudomonas sp. 2hn]
MNSREMISVIEADGWYLVRSKGSHHHFKHPEKPGLVTIPHPKKDLLPATAASILRQARIGYAS

Download         Length: 192 bp

>T212583 NZ_CP107284:4308652-4308909 [Escherichia coli]
ATGAATTTATCCCGTCAGGAACAACATACCTTACACGTTCTCGCTAAAGGTAGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGCCAGCCCTATCGAATCAACACCACCGAGCTGAATAAAGTTCGCGCT
CAGCTCGATAATCGCTAA

Antitoxin


Download         Length: 138 a.a.        Molecular weight: 14950.03 Da        Isoelectric Point: 4.5801

>AT212583 WP_050703389.1 NZ_CP081016:301564-301977 [Pseudomonas sp. 2hn]
MLFPIAILPGDDQHAWGVEVPDIPGCFSAGEDLDNAIAMAREAIEGHLELLAQDQQEIPKASLVSVHAANPSYAGCTWAL
IDIDITRYLGKAEKLNITLPAYLLTRIDSYVQNHPEHKSRSGFLAEAALRILQGDCK

Download         Length: 414 bp

>AT212583 NZ_CP107284:4308921-4309466 [Escherichia coli]
ATGACAGTACACCACTTCACTTTTCATATCACAGATAAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCAGCAAAGAAGCCGATTTAGTGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCCGCGTTATCGCTGCTAGCCC
GGTATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCAACCTTCAAAGGAGAAATGGATTCACCGTTGATGCAC
ATCCTCGCTCCCCTGGCGGTCATACCGGAATACCAAGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAATCACTCACCGCT
CAGCCCATGACCCTGACCGGCCACATCCGGTGCGCAGACCCTGATGAAACCGGAGCACTGACGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References