Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | relBE/ParE-DnaT |
Location | 12997..13519 | Replicon | plasmid p25POL-B |
Accession | NZ_CP081012 | ||
Organism | Escherichia coli strain 25POL |
Toxin (Protein)
Gene name | relE | Uniprot ID | G3CAN5 |
Locus tag | K3072_RS25020 | Protein ID | WP_000220560.1 |
Coordinates | 13238..13519 (+) | Length | 94 a.a. |
Antitoxin (Protein)
Gene name | relB | Uniprot ID | G3CAG1 |
Locus tag | K3072_RS25015 | Protein ID | WP_000121743.1 |
Coordinates | 12997..13248 (+) | Length | 84 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
K3072_RS24990 (8156) | 8156..9133 | + | 978 | WP_001269914.1 | hypothetical protein | - |
K3072_RS24995 (9130) | 9130..9486 | - | 357 | WP_001546351.1 | DNA distortion polypeptide 3 | - |
K3072_RS25000 (9626) | 9626..10069 | - | 444 | WP_001074379.1 | hypothetical protein | - |
K3072_RS25005 (10073) | 10073..10915 | - | 843 | WP_000435063.1 | replication initiation protein | - |
K3072_RS25010 (10936) | 10936..11775 | - | 840 | WP_001546350.1 | replication initiation protein | - |
K3072_RS25015 (12997) | 12997..13248 | + | 252 | WP_000121743.1 | plasmid stabilization protein | Antitoxin |
K3072_RS25020 (13238) | 13238..13519 | + | 282 | WP_000220560.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
K3072_RS25025 (13665) | 13665..13988 | + | 324 | WP_001181903.1 | hypothetical protein | - |
K3072_RS25030 (14033) | 14033..14278 | + | 246 | WP_000356548.1 | hypothetical protein | - |
K3072_RS25035 (14268) | 14268..14483 | + | 216 | WP_001180116.1 | hypothetical protein | - |
K3072_RS25040 (14576) | 14576..14905 | + | 330 | WP_000866648.1 | hypothetical protein | - |
K3072_RS25045 (14948) | 14948..15127 | + | 180 | WP_071526261.1 | hypothetical protein | - |
K3072_RS25050 (15213) | 15213..15362 | + | 150 | WP_000003880.1 | hypothetical protein | - |
K3072_RS25055 (15375) | 15375..15647 | + | 273 | WP_000160399.1 | hypothetical protein | - |
K3072_RS25060 (15878) | 15878..16231 | + | 354 | Protein_23 | H-NS histone family protein | - |
K3072_RS25065 (16286) | 16286..16693 | + | 408 | WP_001546356.1 | hypothetical protein | - |
K3072_RS25070 (16950) | 16950..17414 | + | 465 | WP_001443073.1 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Non-Mobilizable plasmid | - | - | 1..24185 | 24185 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 94 a.a. Molecular weight: 11005.83 Da Isoelectric Point: 10.5938
>T212581 WP_000220560.1 NZ_CP081012:13238-13519 [Escherichia coli]
MTYELAFDRRALKEWQKLGHTIREQFKKKLAERLENPRVPAARLHGHADRYKIKLRASGYRLVYQVIDEKVVLLVIAVGR
RESSEVYQIADLR
MTYELAFDRRALKEWQKLGHTIREQFKKKLAERLENPRVPAARLHGHADRYKIKLRASGYRLVYQVIDEKVVLLVIAVGR
RESSEVYQIADLR
Download Length: 282 bp
>T212581 NZ_CP107284:c3914915-3914517 [Escherichia coli]
ATGCGGGTATTCAAAACAAAACTTATTTGCCTGCAACTTACAGCAGAGGAACTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCGTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGTGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAAGCGCATTTGGTATATTGTCAGGGTGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA
ATGCGGGTATTCAAAACAAAACTTATTTGCCTGCAACTTACAGCAGAGGAACTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCGTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGTGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAAGCGCATTTGGTATATTGTCAGGGTGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9194.43 Da Isoelectric Point: 4.1683
>AT212581 WP_000121743.1 NZ_CP081012:12997-13248 [Escherichia coli]
MSYQILTTTAASITDLKKNPMGTVAEGEGDAVAILNRNEPAFYCVPPKLYAYYRELAEDAELNAVADERMKNPEIVKVNL
DDL
MSYQILTTTAASITDLKKNPMGTVAEGEGDAVAILNRNEPAFYCVPPKLYAYYRELAEDAELNAVADERMKNPEIVKVNL
DDL
Download Length: 252 bp
>AT212581 NZ_CP107284:c3915211-3914918 [Escherichia coli]
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATCACTGAGTTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
GGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTCGAAGCGTTAATGGACATGCTTG
CTGAACAAGAGGAGAAAAAACTGGTTAAGGCGCGCTTCCGTCCGAGTGCCGCAAGATTAGAGGAAATTACACGCCGCGCT
GAACAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATCACTGAGTTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
GGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTCGAAGCGTTAATGGACATGCTTG
CTGAACAAGAGGAGAAAAAACTGGTTAAGGCGCGCTTCCGTCCGAGTGCCGCAAGATTAGAGGAAATTACACGCCGCGCT
GAACAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | G3CAN5 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A3S5I301 |