Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 830108..830942 | Replicon | chromosome |
| Accession | NZ_CP081010 | ||
| Organism | Escherichia coli strain 25POL | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | - |
| Locus tag | K3072_RS04020 | Protein ID | WP_001546172.1 |
| Coordinates | 830108..830485 (-) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | A0A0H2VAY1 |
| Locus tag | K3072_RS04025 | Protein ID | WP_001285596.1 |
| Coordinates | 830562..830942 (-) | Length | 127 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| K3072_RS03990 (825656) | 825656..826590 | - | 935 | Protein_789 | nucleotidyl transferase AbiEii/AbiGii toxin family protein | - |
| K3072_RS03995 (826583) | 826583..826978 | - | 396 | WP_000208383.1 | DUF6088 family protein | - |
| K3072_RS04000 (827047) | 827047..827892 | - | 846 | WP_001280441.1 | DUF4942 domain-containing protein | - |
| K3072_RS04005 (828176) | 828176..829195 | - | 1020 | WP_000875213.1 | IS110 family transposase | - |
| K3072_RS04010 (829409) | 829409..829606 | - | 198 | WP_000839260.1 | DUF957 domain-containing protein | - |
| K3072_RS04015 (829623) | 829623..830111 | - | 489 | WP_000761698.1 | DUF5983 family protein | - |
| K3072_RS04020 (830108) | 830108..830485 | - | 378 | WP_001546172.1 | TA system toxin CbtA family protein | Toxin |
| K3072_RS04025 (830562) | 830562..830942 | - | 381 | WP_001285596.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| K3072_RS04030 (830992) | 830992..831636 | - | 645 | WP_000094917.1 | hypothetical protein | - |
| K3072_RS04035 (831655) | 831655..831876 | - | 222 | WP_000692329.1 | DUF987 domain-containing protein | - |
| K3072_RS04040 (831939) | 831939..832415 | - | 477 | WP_001186726.1 | RadC family protein | - |
| K3072_RS04045 (832431) | 832431..832916 | - | 486 | WP_000849564.1 | antirestriction protein | - |
| K3072_RS04050 (832971) | 832971..833792 | - | 822 | WP_094283809.1 | DUF932 domain-containing protein | - |
| K3072_RS25170 (833971) | 833971..834060 | - | 90 | WP_230607454.1 | DUF905 family protein | - |
| K3072_RS04060 (834203) | 834203..834658 | - | 456 | WP_000581502.1 | IrmA family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | kpsM / kpsT / kpsS / kpsC / kpsU / kpsD / kpsE / kpsF | 807058..832916 | 25858 | |
| - | flank | IS/Tn | - | - | 828176..829195 | 1019 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 14028.98 Da Isoelectric Point: 8.5221
>T212554 WP_001546172.1 NZ_CP081010:c830485-830108 [Escherichia coli]
MKTLPDTHVRAASRCPSPVTIWQTLLTQLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYAQVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRNNYRMVNNITQGKHPEAKR
MKTLPDTHVRAASRCPSPVTIWQTLLTQLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYAQVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRNNYRMVNNITQGKHPEAKR
Download Length: 378 bp
>T212554 NZ_CP107271:648594-649013 [Neisseria gonorrhoeae]
ATGATTTTGCTGGACACGAATGTGATTTCCGAACCTTTGCGCCCACAACCCAATGAACGTGTGGTGGCATGGTTGGATAG
TTTGATATTGGAAGATGTGTATTTGTCTGCCATTACTGTTGCAGAATTGCGTTTGGGTGTGGCGTTGTTGCTCAATGGCA
AGAAAAAGAATGTGCTGCACGAACGTTTGGAACAATCCATTTTGCCTTTATTTGCGGGGCGGATTCTGCCTTTTGATGAA
CCGGTTGCCGCAATCTATGCGCAAATTCGTTCCTATGCCAAAACACATGGCAAAGAGATTGCTGCCGCAGACGGCTATAT
TGCCGCCACTGCAAAACAGCACAGTTTGACAGTTGCTACGCGTGATACCGGCTCATTTTTTGCGGCCGATGTCGCGGTGT
TCAATCCGTGGCACGATTAA
ATGATTTTGCTGGACACGAATGTGATTTCCGAACCTTTGCGCCCACAACCCAATGAACGTGTGGTGGCATGGTTGGATAG
TTTGATATTGGAAGATGTGTATTTGTCTGCCATTACTGTTGCAGAATTGCGTTTGGGTGTGGCGTTGTTGCTCAATGGCA
AGAAAAAGAATGTGCTGCACGAACGTTTGGAACAATCCATTTTGCCTTTATTTGCGGGGCGGATTCTGCCTTTTGATGAA
CCGGTTGCCGCAATCTATGCGCAAATTCGTTCCTATGCCAAAACACATGGCAAAGAGATTGCTGCCGCAGACGGCTATAT
TGCCGCCACTGCAAAACAGCACAGTTTGACAGTTGCTACGCGTGATACCGGCTCATTTTTTGCGGCCGATGTCGCGGTGT
TCAATCCGTGGCACGATTAA
Antitoxin
Download Length: 127 a.a. Molecular weight: 13897.70 Da Isoelectric Point: 4.7959
>AT212554 WP_001285596.1 NZ_CP081010:c830942-830562 [Escherichia coli]
MSDTLPGTTLPDDNKDLPWWGLPCAVTPCFGARLVQEGNRLHYLADRAGIRGRFSNADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCDADTLGSCGYVYLAVYPATETESNPPE
MSDTLPGTTLPDDNKDLPWWGLPCAVTPCFGARLVQEGNRLHYLADRAGIRGRFSNADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCDADTLGSCGYVYLAVYPATETESNPPE
Download Length: 381 bp
>AT212554 NZ_CP107271:648358-648594 [Neisseria gonorrhoeae]
ATGGCTTCTGTTGTGATTAGAAATTTATCCGAGGCCACGCACAACGCAATCAAATTCCGTGCGCGAGCCGCAGGGCGCAG
TACCGAAGCAGAAATCCGCTTAATTTTGGATAACATCGCCAAAGCACAACAAACTGTACGTTTGGGGTCAATGTTGGCAT
CAATAGGGCAGGAAATCGGAGGTGTTGAGCTGGAAGACGTACGCGGTCGTAATACTGATAACGAGGTTTCTTTGTGA
ATGGCTTCTGTTGTGATTAGAAATTTATCCGAGGCCACGCACAACGCAATCAAATTCCGTGCGCGAGCCGCAGGGCGCAG
TACCGAAGCAGAAATCCGCTTAATTTTGGATAACATCGCCAAAGCACAACAAACTGTACGTTTGGGGTCAATGTTGGCAT
CAATAGGGCAGGAAATCGGAGGTGTTGAGCTGGAAGACGTACGCGGTCGTAATACTGATAACGAGGTTTCTTTGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|