Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4135777..4136395 Replicon chromosome
Accession NZ_CP081009
Organism Escherichia coli strain Stbl4

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag K3830_RS19755 Protein ID WP_001291435.1
Coordinates 4136177..4136395 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag K3830_RS19750 Protein ID WP_000344800.1
Coordinates 4135777..4136151 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K3830_RS19740 (4130866) 4130866..4132059 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
K3830_RS19745 (4132082) 4132082..4135231 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
K3830_RS19750 (4135777) 4135777..4136151 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
K3830_RS19755 (4136177) 4136177..4136395 + 219 WP_001291435.1 HHA domain-containing protein Toxin
K3830_RS19760 (4136567) 4136567..4137118 + 552 WP_000102564.1 maltose O-acetyltransferase -
K3830_RS19765 (4137234) 4137234..4137704 + 471 WP_000136192.1 YlaC family protein -
K3830_RS19770 (4137868) 4137868..4139418 + 1551 WP_001310610.1 cyclic-guanylate-specific phosphodiesterase PdeB -
K3830_RS19775 (4139460) 4139460..4139813 - 354 WP_000878140.1 DUF1428 domain-containing protein -
K3830_RS19785 (4140192) 4140192..4140503 + 312 WP_000409911.1 MGMT family protein -
K3830_RS19790 (4140534) 4140534..4141106 - 573 WP_000779842.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T212540 WP_001291435.1 NZ_CP081009:4136177-4136395 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T212540 NZ_CP107262:2597400-2597750 [Leclercia adecarboxylata]
ATGTGGACGGTAATCTTAGGAGAAGTGTTTGAAGCGTGGCTGGAAGATCAAGAACAAGGCGTTCAGGAAAAGGTATTTGC
AGCTCTCATAAACCTGCAAACCTATGGTCCCCGCCTTCCACGTCCCTATGCCGATACAGTCAGAGGCTCGCGACATAACA
ATATGAAAGAATTACGTATTCAATATTATGGCCGTCCGATTCGTGCATTTTTTGCTTTCGATCCCGTGCGTCAGGCTATT
GTGCTTTGCGCAGGCGATAAAAGTCATGACAAAAAATTCTATGAACGACTCATTCGTATTGCAGATGATGAATTTTCGGC
TCACCTGGCAGCAATGGAGACAAGAAATTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT212540 WP_000344800.1 NZ_CP081009:4135777-4136151 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT212540 NZ_CP107262:2597747-2598046 [Leclercia adecarboxylata]
TTGAAAACCTTGAATGAAGCGATCGCTTCGCGTTCCCCTGAAAGCCAAAAACGCATCAAAGAAATGGCCGACGAAATGAT
TCTGGAAACGGGCCTGCAAATGATGCGCGAGGAACTGAAACTATCGCAAAAACACGTTGCGGAAGTGATGGGCATCAGCC
AGCCCGCTATCACCCAGCTTGAGCAGCGTGGCAATGAACTGAAAATCACCACGCTAAAACGCTATATCGAGGCGATGGGC
GGTAAACTAAGCCTGGATGTTGAACTCCCGAACGGAAAACGCGTGGCGTTTCACATTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References