Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/DUF433(antitoxin)
Location 3763423..3763985 Replicon chromosome
Accession NC_007413
Organism Anabaena variabilis ATCC 29413 (Anabaena flos-aquae UTEX 1444)

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag AVA_RS15365 Protein ID WP_011319780.1
Coordinates 3763644..3763985 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag AVA_RS15360 Protein ID WP_011319779.1
Coordinates 3763423..3763647 (+) Length 75 a.a.

Genomic Context

AVA_RS15350AVA_RS15355AVA_RS15360AVA_RS15365AVA_RS15380AVA_RS15370AVA_RS15375
Location: 3760762..3761844 (1083 bp)
Type: Others
Protein ID: WP_011319777.1
Location: 3762009..3763373 (1365 bp)
Type: Others
Protein ID: WP_011319778.1
Location: 3763423..3763647 (225 bp)
Type: Antitoxin
Protein ID: WP_011319779.1
Location: 3763644..3763985 (342 bp)
Type: Toxin
Protein ID: WP_011319780.1
Location: 3765596..3766852 (1257 bp)
Type: Others
Protein ID: WP_041456239.1
Location: 3764018..3764791 (774 bp)
Type: Others
Protein ID: WP_011319781.1
Location: 3765064..3765471 (408 bp)
Type: Others
Protein ID: WP_011319782.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
AVA_RS153503760762..3761844+1083WP_011319777.1serine/threonine protein kinase-
AVA_RS153553762009..3763373+1365WP_011319778.1tRNA (N6-isopentenyl adenosine(37)-C2)-methylthiotransferase MiaB-
AVA_RS153603763423..3763647+225WP_011319779.1DUF433 domain-containing proteinAntitoxin
AVA_RS153653763644..3763985+342WP_011319780.1DUF5615 family PIN-like proteinToxin
AVA_RS153703764018..3764791-774WP_011319781.1hypothetical protein-
AVA_RS153753765064..3765471-408WP_011319782.1hypothetical protein-
AVA_RS153803765596..3766852+1257WP_041456239.1ABC transporter substrate-binding protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Domain of unknown function DUF5615

(4-79)

Antitoxin

Protein of unknown function DUF433

(8-63)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12430.35 Da        Isoelectric Point: 4.2457

>T21254 WP_011319780.1 NC_007413:3763644-3763985 [Trichormus variabilis ATCC 29413]
MTTIWIDAHLSPVIATWINNTFGITALALRDIGLRDAEDLEIFEAAKAQGVIFITKDSDFVDLVERLGEPPKIIWLTCGN
TSNARLQEILSVTLPDALRLLQAGERLVEISGV

Download         Length: 342 bp

>T21254 NC_007413:3763644-3763985 [Trichormus variabilis ATCC 29413]
ATGACAACGATTTGGATTGATGCACATCTGTCGCCGGTGATTGCTACCTGGATTAACAACACATTTGGGATTACAGCATT
GGCATTGCGTGACATTGGCTTGAGGGATGCTGAAGACCTGGAGATTTTTGAAGCAGCAAAAGCTCAAGGAGTTATCTTCA
TCACCAAAGACAGCGATTTTGTTGACTTAGTAGAACGCTTAGGAGAGCCACCAAAAATCATCTGGCTAACCTGCGGTAAT
ACATCAAATGCTCGTTTGCAAGAGATTCTGAGTGTTACACTACCGGACGCATTGAGGCTTCTACAAGCAGGCGAGAGATT
GGTAGAGATTAGCGGAGTTTAA

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8104.53 Da        Isoelectric Point: 7.8328

>AT21254 WP_011319779.1 NC_007413:3763423-3763647 [Trichormus variabilis ATCC 29413]
MSNLLQRITVNPKQCGGRPCIRGMRIRVSDVLDLLAAGLSSEQILAEMPDLEMDDLKASLAYAARKLNHPILTA

Download         Length: 225 bp

>AT21254 NC_007413:3763423-3763647 [Trichormus variabilis ATCC 29413]
ATGTCAAACTTGTTGCAAAGAATCACAGTCAACCCTAAACAGTGTGGTGGTCGTCCCTGCATTCGTGGTATGAGAATTAG
GGTATCAGATGTACTTGATTTGTTAGCTGCGGGACTTAGCTCCGAGCAAATCTTAGCAGAAATGCCCGATTTAGAGATGG
ATGATTTGAAAGCATCACTCGCTTACGCTGCTCGTAAATTAAATCATCCCATCCTGACGGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
No matching records found

References