212536

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 3818627..3819441 Replicon chromosome
Accession NZ_CP081009
Organism Escherichia coli strain Stbl4

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag K3830_RS18300 Protein ID WP_001054376.1
Coordinates 3819184..3819441 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID U9Z4B8
Locus tag K3830_RS18295 Protein ID WP_001309181.1
Coordinates 3818627..3819172 (-) Length 182 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K3830_RS18265 (3814318) 3814318..3815631 - 1314 WP_000460842.1 PTS sugar transporter subunit IIC SgcC -
K3830_RS18270 (3815643) 3815643..3815921 - 279 WP_000722973.1 PTS sugar transporter subunit IIB SgcB -
K3830_RS18275 (3815918) 3815918..3817039 - 1122 WP_000010829.1 M42 family metallopeptidase -
K3830_RS18280 (3817284) 3817284..3817400 - 117 Protein_3596 VOC family protein -
K3830_RS18285 (3817438) 3817438..3817656 - 219 Protein_3597 hypothetical protein -
K3830_RS18290 (3817825) 3817825..3818571 - 747 WP_000354251.1 class I SAM-dependent methyltransferase -
K3830_RS18295 (3818627) 3818627..3819172 - 546 WP_001309181.1 N-acetyltransferase Antitoxin
K3830_RS18300 (3819184) 3819184..3819441 - 258 WP_001054376.1 YjhX family toxin Toxin
K3830_RS22305 (3819932) 3819932..3820063 - 132 WP_001309182.1 hypothetical protein -
K3830_RS18310 (3820179) 3820179..3821419 + 1241 Protein_3602 helicase YjhR -
K3830_RS22310 (3821687) 3821687..3821892 - 206 Protein_3603 HNH endonuclease -
K3830_RS18315 (3822002) 3822002..3822982 - 981 WP_000991438.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
K3830_RS18320 (3823047) 3823047..3824153 - 1107 WP_001309184.1 N-acetylneuraminate epimerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T212536 WP_001054376.1 NZ_CP081009:c3819441-3819184 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

>T212536 NZ_CP107262:c1878563-1877250 [Leclercia adecarboxylata]
ATGAAAATGCAGACGCTAACAGTGGCGATGAATGGTGAGGTCGTAGGAACACTGTACCGAGATAACAAAGGGGCCATGTC
ATTTCAGTATGCCCCGGAGTGGATCTCGGAACCAGGTTCACGCGCCATTTCCATGTCACTGCCTTTGGGTCATGGCAGGA
TCACAGGAAGTGAAGTCTTCAATTTCTTTAGCAACCTCCTACCCGACTCAGAGGCAATTATTGCCAGGATGCAGGCTAGG
TTCAGAGTTGAGACAACACATCCATTTGATTTGCTGGCGAGTGTTGGCCGGGATTGTGTTGGAGCTATCCAGCTCTATTC
CCCCGATGCGGACATCCCAACTGTAATGGAGACGCTTGCAGAGCCTCTGGATGAAGCTCAGATTGAGCAACTGCTTGAAG
GCTACCAGGAAGCGCCCCTTGGGATGGCAGAGGATGCTGATTTTCGGATCTCGATTGCCGGAGCCCAAGAGAAAACTGCA
CTGCTTTGGTATCAGGACCGCTGGCAACGCCCCCTGGGCAGCACCCCAACAAGCCATATTTTTAAGCTACCCATTGGTAA
GATTGTTCAAAATAACATCGATCTCAGTGAGAGTTGTGAGAATGAATGGCTCTGTTTGCGCATTGCAAAGGCCTTCGGTT
TTGACGTCGCCAATGCGGACCTAGCAACGTTCGGCAAGAAGAAGGTGCTTGTCGTTCAGCGTTTTGACCGGCGCTGGTCT
AAATCCGGCGAATGGCTTCTACGATTGCCCCAAGAAGACTTCTGCCAAGCTCTTGGGATCGCTCCTGCGCTCAAATACGA
GTCACATGGAGGGCCAGGTATTGCTGACGCAATGAAGTTGTTGTTGGGGTCCAGACTTGCGGCTAAGGATAGAGAGCAAT
TTTTCAAGTCGCAGATCCTATTCTGGATGTTGGCCGCGATTGATGGGCACGGGAAGAACTTCTCCATCTTCATTGAGCCT
GCATCGTCATTTAGGATGACCCCCCTCTACGATGTCATGTCTGCTTTTCCTATCTTCAAAAGCGGGGGAATTGCTGCTCA
AAAGGCCAAGATGGGGATGGCGCTCCAAGGCAAAAACCGCCAATACCATTTTGCGATGATCCAGCCTCGTCATTTTATCA
GTACCGCCGCCCATGTCGGGTTCCCACAAGATACCGCCGCTCAACTTATGTTCGACATGGCTACCAAGACAGAGGAGGTG
GTTGCCACAGTAGCGGCTGAGCTGCCAGCCGGTTTCCCAGAGCACATCAGTAGCGCCATCTTCGAGGGGCTGTCCAGCCA
GGCGGCTAAGATCTTGAAGGGAGTAGCCAAATGA

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19956.90 Da        Isoelectric Point: 6.3277

>AT212536 WP_001309181.1 NZ_CP081009:c3819172-3818627 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp

>AT212536 NZ_CP107262:c1878818-1878567 [Leclercia adecarboxylata]
ATGAAAGTGACATCTCCATCCTTGCTTGCGGCTGCGGTGCGTGACCAGCGCAAGCTCAGCAAACTAACGCAGTCAGAGGC
GGCGAAACAGGTCGGAATCAAGCAGACGACCGTCTCTGATTTTGAACTACGGCCAGAATCTACCAAGCTGGAGACGCTAT
TCAAGCTCCTTTCTGCACTGGATCTGGAGCTTCATGTCGTGAAGCGGGGTTCAACATTGGACGATAGTAAAGTCTGGGAT
AGGGAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PA82

Antitoxin

Source ID Structure
AlphaFold DB U9Z4B8

References