Detailed information of TA system TA021253

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/CC2985(antitoxin)
• Location: 3355504..3356051
• Replicon: chromosome
• Accession: NC_007406
• Organism: Nitrobacter winogradskyi Nb-255

Toxin (Protein)

• Gene name: parE
• Uniprot ID: Q3SN02
• Locus tag: NWI_RS16090
• Protein ID: WP_011316252.1
• Coordinates: 3355504..3355797 (-)
• Length: 98 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: Q3SN01
• Locus tag: NWI_RS16095
• Protein ID: WP_011316253.1
• Coordinates: 3355797..3356051 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
NWI_RS16075	3352646..3354007	-	1362	Protein_3058	chromosome partitioning protein ParB	-
NWI_RS16080	3354265..3354963	-	699	WP_011316250.1	isoprenylcysteine carboxylmethyltransferase family protein	-
NWI_RS16085	3355012..3355326	-	315	WP_041345222.1	YdeI/OmpD-associated family protein	-
NWI_RS16090	3355504..3355797	-	294	WP_011316252.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
NWI_RS16095	3355797..3356051	-	255	WP_011316253.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
NWI_RS16100	3356164..3356421	-	258	WP_041345224.1	hypothetical protein	-
NWI_RS16105	3356539..3356796	-	258	WP_011316255.1	hypothetical protein	-
NWI_RS16110	3357217..3357630	+	414	WP_148203894.1	hypothetical protein	-
NWI_RS17280	3358048..3358209	-	162	Protein_3066	DNA-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-91)

Antitoxin

• Antitoxin ParD (6-63)

Sequences

Toxin

Protein

• Length: 98 a.a.
• Molecular weight: 11109.71 Da
• Isoelectric Point: 6.2166

>T21253 WP_011316252.1 NC_007406:c3355797-3355504 [Nitrobacter winogradskyi Nb-255]
MSFRLSLAAEDDIIGIAEEGVRLFGPAQARQYHDDLFAILDLIAANPRMARERHELSPPMRIHPFKAHLVIYRIEEDGVL
IVRVRHGHEDWVSEGAR

Nucleotide

• Length: 294 bp

>T21253 NC_007406:c3355797-3355504 [Nitrobacter winogradskyi Nb-255]
ATGAGCTTTCGCCTCTCTCTCGCGGCGGAAGACGACATTATCGGTATTGCCGAAGAAGGCGTGCGCCTGTTCGGTCCCGC
GCAGGCGAGGCAATACCATGATGATCTGTTTGCGATCCTCGACCTGATCGCGGCCAATCCCCGCATGGCGCGGGAGCGTC
ACGAGTTGTCGCCACCGATGCGTATCCATCCCTTCAAGGCCCATCTTGTCATCTACCGGATCGAGGAGGACGGCGTCCTC
ATTGTCCGCGTGCGCCACGGGCACGAGGATTGGGTAAGCGAAGGGGCACGGTAG

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9219.24 Da
• Isoelectric Point: 6.3187

>AT21253 WP_011316253.1 NC_007406:c3356051-3355797 [Nitrobacter winogradskyi Nb-255]
MATMNVSLPDAMKDWVEAQAETGRYANASDYVRDLIRKDQERNDKIAAMQRFVDEGLNSGAGNRSKDALFAEAVKRAGTP
RGNG

Nucleotide

• Length: 255 bp

>AT21253 NC_007406:c3356051-3355797 [Nitrobacter winogradskyi Nb-255]
ATGGCAACGATGAACGTATCCTTGCCCGACGCGATGAAGGACTGGGTCGAAGCGCAAGCCGAAACAGGTCGCTACGCCAA
TGCGAGCGACTATGTACGCGATTTGATCCGCAAGGATCAGGAGCGCAATGACAAGATTGCGGCCATGCAGCGCTTTGTCG
ATGAAGGTCTGAATAGCGGCGCCGGCAATCGTTCCAAAGACGCGCTGTTTGCTGAAGCGGTCAAACGCGCTGGAACGCCG
CGCGGCAACGGCTGA

Structures

Toxin

• AlphaFold DB: Q3SN02

Antitoxin

• AlphaFold DB: Q3SN01