Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 182581..183116 Replicon plasmid pSS_046
Accession NC_007385
Organism Shigella sonnei Ss046

Toxin (Protein)


Gene name relE Uniprot ID Q3YTD6
Locus tag SSON_RS26420 Protein ID WP_000222766.1
Coordinates 182829..183116 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0I0JNN8
Locus tag SSON_RS26415 Protein ID WP_001132903.1
Coordinates 182581..182832 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SSON_RS26370 (SSO_P200) 177847..178308 + 462 WP_001233865.1 thermonuclease family protein -
SSON_RS26375 (SSO_P201) 178354..178563 + 210 WP_001299729.1 hemolysin expression modulator Hha -
SSON_RS26380 178602..178847 + 246 Protein_209 hypothetical protein -
SSON_RS26390 179616..179969 + 354 Protein_211 DUF2726 domain-containing protein -
SSON_RS26395 (SSO_P204) 180209..180469 + 261 WP_000083819.1 replication regulatory protein RepA -
SSON_RS26400 180693..180767 + 75 WP_001365705.1 RepA leader peptide Tap -
SSON_RS26405 (SSO_P205) 180760..181617 + 858 WP_000130974.1 incFII family plasmid replication initiator RepA -
SSON_RS33385 (SSO_P206) 182317..182508 + 192 WP_000829591.1 hypothetical protein -
SSON_RS26415 (SSO_P207) 182581..182832 + 252 WP_001132903.1 plasmid stabilization protein Antitoxin
SSON_RS26420 (SSO_P208) 182829..183116 + 288 WP_000222766.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
SSON_RS26425 (SSO_P209) 183349..184548 - 1200 WP_000947184.1 IS91 family transposase -
SSON_RS33390 184558..184746 - 189 WP_000957853.1 hypothetical protein -
SSON_RS26435 (SSO_P210) 184868..185026 + 159 Protein_220 transposase -
SSON_RS32845 (SSO_P211) 185165..185320 + 156 Protein_221 IS256 family transposase -
SSON_RS26445 (SSO_P212) 185350..187077 - 1728 WP_000597732.1 T3SS effector E3 ubiquitin-protein ligase IpaH1.4 -
SSON_RS30360 (SSO_P213) 187467..187686 - 220 Protein_223 hypothetical protein -
SSON_RS32345 187843..187940 - 98 Protein_224 IS1 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - ospB / ospC4 / ospD2 / ospF / ospD1 / ipgB2 / ospE2 / ospC1 / ospD3/senA / ipaH7.8 / ipaH4.5 / ospC2 / ospC3 / ipaJ / ipaA / ipaD / ipaC / ipaB / ipgC / ipgB1 / ipgA / icsB / ipgD / ipgE / ipgF / mxiG / mxiH / mxiI / mxiJ / mxiK / mxiN / mxiL / mxiM / mxiE / mxiD / mxiC / mxiA / spa15 / spa47 / spa13 / spa32 / spa33 / spa24 / spa9 / spa29 / spa40 / virA / icsA/virG / papC / ospI / ipaH9.8 / ospG / ipaH1.4 / tviC / nleE / icsP/sopA 1..214396 214396
- inside IScluster/Tn - ipaH1.4 173682..193063 19381


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11147.23 Da        Isoelectric Point: 10.5832

>T21252 WP_000222766.1 NC_007385:182829-183116 [Shigella sonnei Ss046]
MTYTVKFRDDALKEWLKLDKTIQQQFVKKLKKCSENPHIPSAKLRGLKDCYKIKLRASGFRLVYQVIDDMLIIAVVAVGK
RERSNVYNLASERMR

Download         Length: 288 bp

>T21252 NC_007385:182829-183116 [Shigella sonnei Ss046]
ATGACTTATACGGTAAAATTCAGGGATGATGCGCTCAAGGAATGGCTGAAACTGGATAAGACCATTCAACAACAGTTTGT
GAAAAAACTAAAAAAATGCAGCGAAAATCCTCATATACCGTCGGCAAAACTAAGAGGGCTAAAGGACTGCTACAAAATTA
AACTACGTGCATCGGGATTTCGTCTGGTTTATCAGGTGATTGACGATATGTTAATTATTGCGGTTGTTGCGGTAGGAAAA
CGAGAACGTAGTAACGTTTATAATCTCGCCAGTGAGAGAATGAGATAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9225.44 Da        Isoelectric Point: 4.0927

>AT21252 WP_001132903.1 NC_007385:182581-182832 [Shigella sonnei Ss046]
MPNIILSETSASVSELKKNPMATVSAGDGYPVAILNRNQPAFYCVPAELYERMLDALDDQELVKLVTERSNQPLHDVDLD
SYL

Download         Length: 252 bp

>AT21252 NC_007385:182581-182832 [Shigella sonnei Ss046]
ATGCCTAACATCATTCTGTCTGAGACCAGTGCAAGTGTCAGTGAACTGAAAAAAAATCCTATGGCTACAGTCAGTGCCGG
AGATGGTTACCCTGTCGCCATTCTTAACCGGAATCAGCCGGCATTCTACTGTGTGCCTGCTGAACTGTATGAAAGGATGC
TTGATGCTCTGGATGACCAGGAACTGGTGAAACTGGTTACTGAACGCAGCAATCAGCCACTGCATGATGTGGACCTGGAC
AGTTATTTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CDZ2

Antitoxin

Source ID Structure
AlphaFold DB A0A0I0JNN8

References