Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-RelB |
| Location | 4400055..4400581 | Replicon | chromosome |
| Accession | NZ_CP081008 | ||
| Organism | Escherichia coli strain XL10-gold-ultracompetent | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | S1EXL1 |
| Locus tag | K3831_RS21400 | Protein ID | WP_000323025.1 |
| Coordinates | 4400055..4400342 (-) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | S1F6D3 |
| Locus tag | K3831_RS21405 | Protein ID | WP_000534858.1 |
| Coordinates | 4400342..4400581 (-) | Length | 80 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| K3831_RS21350 (4395079) | 4395079..4395294 | - | 216 | WP_000839590.1 | phage lysis protein EssD | - |
| K3831_RS21355 (4395514) | 4395514..4395684 | + | 171 | WP_211180497.1 | putative zinc-binding protein YnfU | - |
| K3831_RS21360 (4396048) | 4396048..4396263 | - | 216 | WP_000066484.1 | cold shock-like protein CspB | - |
| K3831_RS21365 (4396564) | 4396564..4396776 | + | 213 | WP_000087756.1 | cold shock-like protein CspF | - |
| K3831_RS21370 (4396831) | 4396831..4396920 | + | 90 | WP_120795389.1 | hypothetical protein | - |
| K3831_RS21375 (4397198) | 4397198..4397950 | - | 753 | WP_001047135.1 | antitermination protein | - |
| K3831_RS21380 (4397964) | 4397964..4399013 | - | 1050 | WP_001265198.1 | DUF968 domain-containing protein | - |
| K3831_RS21385 (4399015) | 4399015..4399293 | - | 279 | WP_012304870.1 | hypothetical protein | - |
| K3831_RS21390 (4399360) | 4399360..4399611 | - | 252 | WP_000980994.1 | protein Rem | - |
| K3831_RS21395 (4399828) | 4399828..4399983 | - | 156 | WP_000813254.1 | type I toxin-antitoxin system toxin HokD | - |
| K3831_RS21400 (4400055) | 4400055..4400342 | - | 288 | WP_000323025.1 | type II toxin-antitoxin system mRNA interferase RelE | Toxin |
| K3831_RS21405 (4400342) | 4400342..4400581 | - | 240 | WP_000534858.1 | type II toxin-antitoxin system antitoxin RelB | Antitoxin |
| K3831_RS21410 (4400606) | 4400606..4400911 | + | 306 | WP_001326990.1 | protein YdfV | - |
| K3831_RS21415 (4401114) | 4401114..4401446 | + | 333 | WP_001301033.1 | FlxA-like family protein | - |
| K3831_RS21420 (4401883) | 4401883..4402032 | - | 150 | WP_011443592.1 | protein YdfW | - |
| K3831_RS21425 (4402067) | 4402067..4402345 | - | 279 | Protein_4249 | hypothetical protein | - |
| K3831_RS21430 (4402329) | 4402329..4402559 | - | 231 | WP_000920568.1 | dicB transcriptional regulator DicC | - |
| K3831_RS21435 (4402643) | 4402643..4403050 | + | 408 | WP_000448564.1 | DNA-binding transcriptional dual regulator DicA | - |
| K3831_RS21440 (4403217) | 4403217..4403372 | + | 156 | WP_000379575.1 | DUF1391 family protein | - |
| K3831_RS23325 (4403374) | 4403374..4403502 | + | 129 | WP_000344964.1 | protein YdfB | - |
| K3831_RS21445 (4403532) | 4403532..4403750 | + | 219 | WP_001171942.1 | protein YdfC | - |
| K3831_RS21450 (4404318) | 4404318..4404386 | + | 69 | Protein_4255 | cell division inhibition protein DicB | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11225.22 Da Isoelectric Point: 10.1967
>T212513 WP_000323025.1 NZ_CP081008:c4400342-4400055 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
Download Length: 288 bp
>T212513 NZ_CP107241:c4918415-4918116 [Xanthomonas hortorum]
ATGGCCTACACGGTGAAACAACTTGATGAGTTCTCTGGATGGCTCAGAGGCTTGAAGGATGGGCTGACACGACAGCGGCT
CATCAAGCGGCTGCGCAAGGTCCAGCTTGGCAACTTGGGCGACGTGGAGCCTGTAGGCGAAGGCGTGTTCGAGATGCGCG
AACATTTCGGGCCAGGCTGGCGCATGTACTACGTCCAGCACGGCGAGTTGGTGATTGTGATGCTGGGCGGCGGTGACAAG
TCCACCCAGCAGGCCGACATTCGACGCGCCACTGCGTTGGCGAAATCCTTGGAGGATTGA
ATGGCCTACACGGTGAAACAACTTGATGAGTTCTCTGGATGGCTCAGAGGCTTGAAGGATGGGCTGACACGACAGCGGCT
CATCAAGCGGCTGCGCAAGGTCCAGCTTGGCAACTTGGGCGACGTGGAGCCTGTAGGCGAAGGCGTGTTCGAGATGCGCG
AACATTTCGGGCCAGGCTGGCGCATGTACTACGTCCAGCACGGCGAGTTGGTGATTGTGATGCTGGGCGGCGGTGACAAG
TCCACCCAGCAGGCCGACATTCGACGCGCCACTGCGTTGGCGAAATCCTTGGAGGATTGA
Antitoxin
Download Length: 80 a.a. Molecular weight: 9071.48 Da Isoelectric Point: 4.5230
>AT212513 WP_000534858.1 NZ_CP081008:c4400581-4400342 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
Download Length: 240 bp
>AT212513 NZ_CP107241:c4918119-4917802 [Xanthomonas hortorum]
TTGACTATGACCAAGAAAATTAAGGTTTCCGAACTCTCCGAGTTCGATGCGGCCGAATATTTGAACGACGAAGAGGATGT
GGCGGCATACCTGACAACCGTTCTTGAAGAGAATGACTCGGCGCTGCTGGCCGCTGCTCTCGGTGACATTGCCCGGGCGC
GAGGAATGTCGCAGGTTGCGAAGGAGGCTGGTATTGCTCGCGAAGCCCTGTACAAAGCGCTTCGTCCCGGCAGCGAACCG
CGCTTCGAGACGATCAGTCGCGTTTGCGCTGCCTTGGGCGTGCGCCTGGTGGCTCAGCCGATACATCTAGCGAACTGA
TTGACTATGACCAAGAAAATTAAGGTTTCCGAACTCTCCGAGTTCGATGCGGCCGAATATTTGAACGACGAAGAGGATGT
GGCGGCATACCTGACAACCGTTCTTGAAGAGAATGACTCGGCGCTGCTGGCCGCTGCTCTCGGTGACATTGCCCGGGCGC
GAGGAATGTCGCAGGTTGCGAAGGAGGCTGGTATTGCTCGCGAAGCCCTGTACAAAGCGCTTCGTCCCGGCAGCGAACCG
CGCTTCGAGACGATCAGTCGCGTTTGCGCTGCCTTGGGCGTGCGCCTGGTGGCTCAGCCGATACATCTAGCGAACTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|