Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 4573010..4573507 Replicon chromosome
Accession NC_007384
Organism Shigella sonnei Ss046

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag SSON_RS23865 Protein ID WP_001173343.1
Coordinates 4573334..4573507 (+) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID L4JK92
Locus tag SSON_RS23860 Protein ID WP_000398619.1
Coordinates 4573010..4573306 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SSON_RS23840 (4569741) 4569741..4570460 - 720 WP_000611285.1 two-component system response regulator DcuR -
SSON_RS23845 (4570457) 4570457..4572088 - 1632 WP_001216495.1 sensor histidine kinase -
SSON_RS23850 (4572269) 4572269..4572499 + 231 WP_000371698.1 4Fe-4S mono-cluster protein YjdI -
SSON_RS23855 (4572511) 4572511..4572783 + 273 WP_000405647.1 GNAT family N-acetyltransferase -
SSON_RS23860 (4573010) 4573010..4573306 + 297 WP_000398619.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
SSON_RS23865 (4573334) 4573334..4573507 + 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
SSON_RS23870 (4573626) 4573626..4575143 - 1518 WP_001295086.1 lysine--tRNA ligase -
SSON_RS23875 (4575380) 4575380..4576837 - 1458 WP_000856831.1 dipeptide/tripeptide permease DtpC -
SSON_RS23880 (4576896) 4576896..4577153 - 258 Protein_4495 lysine decarboxylase LdcC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T21250 WP_001173343.1 NC_007384:4573334-4573507 [Shigella sonnei Ss046]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

>T21250 NC_007384:4573334-4573507 [Shigella sonnei Ss046]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11467.97 Da        Isoelectric Point: 4.1705

>AT21250 WP_000398619.1 NC_007384:4573010-4573306 [Shigella sonnei Ss046]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp

>AT21250 NC_007384:4573010-4573306 [Shigella sonnei Ss046]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCTTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAATT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTTAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
PDB 2LLZ
AlphaFold DB A0A7U9QBH6

References