Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 2502303..2502898 Replicon chromosome
Accession NZ_CP081008
Organism Escherichia coli strain XL10-gold-ultracompetent

Toxin (Protein)


Gene name chpB Uniprot ID U9XNP6
Locus tag K3831_RS11895 Protein ID WP_000239577.1
Coordinates 2502548..2502898 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag K3831_RS11890 Protein ID WP_001223208.1
Coordinates 2502303..2502554 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K3831_RS11880 (2497968) 2497968..2501747 + 3780 WP_000060911.1 autotransporter assembly complex protein TamB -
K3831_RS11885 (2501750) 2501750..2502091 + 342 WP_001219160.1 gamma-glutamylcyclotransferase -
K3831_RS11890 (2502303) 2502303..2502554 + 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
K3831_RS11895 (2502548) 2502548..2502898 + 351 WP_000239577.1 endoribonuclease toxin ChpB Toxin
K3831_RS11900 (2502978) 2502978..2503508 - 531 WP_000055075.1 inorganic diphosphatase -
K3831_RS11905 (2503818) 2503818..2504774 + 957 WP_000265913.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
K3831_RS11910 (2504914) 2504914..2506416 + 1503 WP_000205825.1 sugar ABC transporter ATP-binding protein -
K3831_RS11915 (2506430) 2506430..2507452 + 1023 WP_001313531.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12492.40 Da        Isoelectric Point: 5.5572

>T212497 WP_000239577.1 NZ_CP081008:2502548-2502898 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLHARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

>T212497 NZ_CP107078:9784-10200 [Kosakonia cowanii]
GTGAACAAAACGTATATGCTGGACACCTGTATCTGCTCATTCATCATGCGCGAGCAGCCGGAAGCGGTGCTGAAGCGCCT
TGAGCAGGAGGTGCTGCGCGGTCACCGCATTGTGGTCTCGGCCATCACCTACTCCGAAATGCGCTTCGGCGCCACCGGCC
CGAAGGCCTCGCCCCGTCACGTGCAGCTGGTCGAGGAATTCTGCGCCCGGCTCGATGCCGTCCTGCCCTGGGACCGTTGC
GCAGTGGACGCCACCACGGAAATCCGGGTTGCGCTGCGCCTCGCCGGCACGCCAATTGGCCCGAATGACACGGCGATTGC
CGGGCATGCCATCGCGACCGGTGCCGTGCTGGTTACGAATAATGTGAGAGAGTTTGAGCGGGTACCGGGTCTGACACTGG
AAGACTGGGTTAATTAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT212497 WP_001223208.1 NZ_CP081008:2502303-2502554 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp

>AT212497 NZ_CP107078:9557-9787 [Kosakonia cowanii]
ATGAGAACCGTATCCATTTTTAAAAACGGCAACAACCGCGCCATTCGCCTTCCCCGCGATCTGGATTTTGAGGGGGTGAG
CGAGCTGGAAATCGTCCGGGAAGGGGACAGCATCATCCTCCGTCCCGTCCGGCCGACTTGGCGCTCATTCCTGGAGCTCG
AAAAAGCCGATCCGGATTTTATGGCGGAGCGCGAGGACGTTGTCAGCGACGAAGGACGATTTGACCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9XNP6

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References