Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-RelB |
| Location | 4466544..4467070 | Replicon | chromosome |
| Accession | NZ_CP081007 | ||
| Organism | Escherichia coli strain XL1-Blue | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | S1EXL1 |
| Locus tag | K3826_RS21495 | Protein ID | WP_000323025.1 |
| Coordinates | 4466783..4467070 (+) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | S1F6D3 |
| Locus tag | K3826_RS21490 | Protein ID | WP_000534858.1 |
| Coordinates | 4466544..4466783 (+) | Length | 80 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| K3826_RS21435 (4461574) | 4461574..4462338 | - | 765 | Protein_4215 | exonuclease | - |
| K3826_RS21440 (4462431) | 4462431..4462622 | - | 192 | WP_001083297.1 | lysis protein YdfD | - |
| K3826_RS21445 (4462619) | 4462619..4462807 | - | 189 | WP_000854559.1 | cell division inhibition protein DicB | - |
| K3826_RS21450 (4463375) | 4463375..4463593 | - | 219 | WP_001171942.1 | protein YdfC | - |
| K3826_RS22880 (4463623) | 4463623..4463751 | - | 129 | WP_000344964.1 | protein YdfB | - |
| K3826_RS21455 (4463753) | 4463753..4463908 | - | 156 | WP_000379575.1 | DUF1391 family protein | - |
| K3826_RS21460 (4464075) | 4464075..4464482 | - | 408 | WP_000448564.1 | DNA-binding transcriptional dual regulator DicA | - |
| K3826_RS21465 (4464566) | 4464566..4464796 | + | 231 | WP_000920568.1 | dicB transcriptional regulator DicC | - |
| K3826_RS21470 (4464780) | 4464780..4465058 | + | 279 | Protein_4223 | hypothetical protein | - |
| K3826_RS21475 (4465093) | 4465093..4465242 | + | 150 | WP_011443592.1 | protein YdfW | - |
| K3826_RS21480 (4465679) | 4465679..4466011 | - | 333 | WP_001301033.1 | FlxA-like family protein | - |
| K3826_RS21485 (4466214) | 4466214..4466519 | - | 306 | WP_001326990.1 | protein YdfV | - |
| K3826_RS21490 (4466544) | 4466544..4466783 | + | 240 | WP_000534858.1 | type II toxin-antitoxin system antitoxin RelB | Antitoxin |
| K3826_RS21495 (4466783) | 4466783..4467070 | + | 288 | WP_000323025.1 | type II toxin-antitoxin system mRNA interferase RelE | Toxin |
| K3826_RS21500 (4467142) | 4467142..4467297 | + | 156 | WP_000813254.1 | type I toxin-antitoxin system toxin HokD | - |
| K3826_RS21505 (4467514) | 4467514..4467765 | + | 252 | WP_000980994.1 | protein Rem | - |
| K3826_RS21510 (4467832) | 4467832..4468110 | + | 279 | WP_012304870.1 | hypothetical protein | - |
| K3826_RS21515 (4468112) | 4468112..4469161 | + | 1050 | WP_001265198.1 | DUF968 domain-containing protein | - |
| K3826_RS21520 (4469175) | 4469175..4469927 | + | 753 | WP_001047135.1 | antitermination protein | - |
| K3826_RS21525 (4470205) | 4470205..4470294 | - | 90 | WP_120795389.1 | hypothetical protein | - |
| K3826_RS21530 (4470349) | 4470349..4470561 | - | 213 | WP_000087756.1 | cold shock-like protein CspF | - |
| K3826_RS21535 (4470862) | 4470862..4471077 | + | 216 | WP_000066484.1 | cold shock-like protein CspB | - |
| K3826_RS21540 (4471441) | 4471441..4471611 | - | 171 | WP_211180497.1 | putative zinc-binding protein YnfU | - |
| K3826_RS21545 (4471831) | 4471831..4472046 | + | 216 | WP_000839590.1 | phage lysis protein EssD | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 4456413..4484837 | 28424 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11225.22 Da Isoelectric Point: 10.1967
>T212473 WP_000323025.1 NZ_CP081007:4466783-4467070 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
Download Length: 288 bp
>T212473 NZ_CP107043:3605284-3605694 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA
Antitoxin
Download Length: 80 a.a. Molecular weight: 9071.48 Da Isoelectric Point: 4.5230
>AT212473 WP_000534858.1 NZ_CP081007:4466544-4466783 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
Download Length: 240 bp
>AT212473 NZ_CP107043:3605037-3605303 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|