Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 3289615..3290210 Replicon chromosome
Accession NZ_CP081007
Organism Escherichia coli strain XL1-Blue

Toxin (Protein)


Gene name chpB Uniprot ID U9XNP6
Locus tag K3826_RS15610 Protein ID WP_000239577.1
Coordinates 3289860..3290210 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag K3826_RS15605 Protein ID WP_001223208.1
Coordinates 3289615..3289866 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K3826_RS15595 (3285280) 3285280..3289059 + 3780 WP_000060911.1 autotransporter assembly complex protein TamB -
K3826_RS15600 (3289062) 3289062..3289403 + 342 WP_001219160.1 gamma-glutamylcyclotransferase -
K3826_RS15605 (3289615) 3289615..3289866 + 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
K3826_RS15610 (3289860) 3289860..3290210 + 351 WP_000239577.1 endoribonuclease toxin ChpB Toxin
K3826_RS15615 (3290290) 3290290..3290820 - 531 WP_000055075.1 inorganic diphosphatase -
K3826_RS15620 (3291130) 3291130..3292086 + 957 WP_000265913.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
K3826_RS15625 (3292226) 3292226..3293728 + 1503 WP_000205825.1 sugar ABC transporter ATP-binding protein -
K3826_RS15630 (3293742) 3293742..3294764 + 1023 WP_001313531.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12492.40 Da        Isoelectric Point: 5.5572

>T212461 WP_000239577.1 NZ_CP081007:3289860-3290210 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLHARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

>T212461 NZ_CP107040:2162939-2163042 [Klebsiella oxytoca]
GGCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTTTTTTT

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT212461 WP_001223208.1 NZ_CP081007:3289615-3289866 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp

>AT212461 NZ_CP107040:c2163049-2162904 [Klebsiella oxytoca]
AAAAGATAAAAAAAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCCTTATAAGAATAGTTTACCGTGTCAGGTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9XNP6

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References