Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 1657952..1658436 Replicon chromosome
Accession NC_007384
Organism Shigella sonnei Ss046

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A377EAU1
Locus tag SSON_RS08660 Protein ID WP_014334020.1
Coordinates 1657952..1658242 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID A0A376K4R9
Locus tag SSON_RS08665 Protein ID WP_005142544.1
Coordinates 1658242..1658436 (-) Length 65 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SSON_RS08625 (1653023) 1653023..1653637 - 615 WP_000148710.1 Tat proofreading chaperone DmsD -
SSON_RS08630 (1653680) 1653680..1654534 - 855 WP_000526502.1 dimethyl sulfoxide reductase anchor subunit family protein -
SSON_RS08635 (1654536) 1654536..1655153 - 618 WP_000213029.1 dimethylsulfoxide reductase subunit B -
SSON_RS08640 (1655164) 1655164..1656240 - 1077 Protein_1624 molybdopterin dinucleotide binding domain-containing protein -
SSON_RS08645 (1656298) 1656298..1656995 + 698 WP_094096600.1 IS1-like element IS1A family transposase -
SSON_RS08650 (1657143) 1657143..1657508 - 366 WP_024174355.1 hypothetical protein -
SSON_RS08655 (1657520) 1657520..1657672 - 153 WP_000379558.1 DUF1391 family protein -
SSON_RS08660 (1657952) 1657952..1658242 - 291 WP_014334020.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
SSON_RS08665 (1658242) 1658242..1658436 - 195 WP_005142544.1 hypothetical protein Antitoxin
SSON_RS08670 (1658456) 1658456..1658941 - 486 WP_053002468.1 helix-turn-helix domain-containing protein -
SSON_RS28025 (1659068) 1659068..1659331 + 264 WP_001048456.1 helix-turn-helix transcriptional regulator -
SSON_RS08680 (1659328) 1659328..1659753 + 426 WP_000693826.1 toxin YdaT family protein -
SSON_RS08685 (1659825) 1659825..1660889 + 1065 WP_001262380.1 hypothetical protein -
SSON_RS08690 (1660896) 1660896..1661642 + 747 WP_000788740.1 ATP-binding protein -
SSON_RS08695 (1661664) 1661664..1662389 + 726 WP_000450631.1 DUF1627 domain-containing protein -
SSON_RS08700 (1662405) 1662405..1662827 + 423 WP_001151171.1 DUF977 family protein -
SSON_RS08705 (1662885) 1662885..1663241 + 357 WP_005140877.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - sodB / rhs/PAAR / rhs/PAAR / vgrG/tssI 1567323..1793522 226199


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11062.93 Da        Isoelectric Point: 10.2013

>T21244 WP_014334020.1 NC_007384:c1658242-1657952 [Shigella sonnei Ss046]
MLPVLWLPSARDDLRQIVAYIAKENPAAARRMKIRIETSVLPLTEHPYLYPPSERVLGLREIVTHPNYIILYRVTASSIE
VVNIVHSRRQYPGKNS

Download         Length: 291 bp

>T21244 NC_007384:c1658242-1657952 [Shigella sonnei Ss046]
ATGTTACCCGTTTTATGGCTACCATCTGCTCGTGATGATTTGCGCCAGATCGTAGCCTACATAGCTAAAGAAAATCCCGC
GGCAGCACGCAGAATGAAAATTCGAATTGAAACATCCGTTTTGCCGCTCACAGAGCATCCTTACCTGTATCCTCCAAGCG
AGCGAGTTCTTGGTCTTCGTGAAATTGTAACTCATCCTAACTACATCATCCTTTACCGAGTAACAGCATCAAGCATAGAA
GTAGTAAATATTGTGCATTCTCGAAGACAGTATCCAGGCAAAAACAGTTAA

Antitoxin


Download         Length: 65 a.a.        Molecular weight: 7097.98 Da        Isoelectric Point: 4.1759

>AT21244 WP_005142544.1 NC_007384:c1658436-1658242 [Shigella sonnei Ss046]
MSTVLSPMVSEFETVEQENSYNEWLRAKVAASLADPRPAIPHDEVMAEMEQIIAQIAAATHRGE

Download         Length: 195 bp

>AT21244 NC_007384:c1658436-1658242 [Shigella sonnei Ss046]
ATGAGTACAGTCCTTTCCCCAATGGTTTCAGAATTTGAGACAGTTGAGCAAGAAAATAGTTACAACGAATGGCTGCGGGC
CAAAGTAGCAGCAAGCCTCGCGGATCCCCGCCCGGCGATTCCGCATGATGAGGTAATGGCGGAAATGGAACAAATTATTG
CCCAAATTGCTGCTGCAACTCACAGAGGTGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A377EAU1

Antitoxin

Source ID Structure
AlphaFold DB A0A376K4R9

References