Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 1648128..1648819 Replicon chromosome
Accession NZ_CP081006
Organism Mycobacterium sp. IDR2000157661

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag K3G64_RS08940 Protein ID WP_238949223.1
Coordinates 1648379..1648819 (+) Length 147 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag K3G64_RS08935 Protein ID WP_238949219.1
Coordinates 1648128..1648382 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K3G64_RS08915 (K3G64_08855) 1643566..1644390 - 825 WP_238949214.1 TetR family transcriptional regulator -
K3G64_RS08920 (K3G64_08860) 1644510..1645607 + 1098 WP_238949216.1 ferredoxin reductase -
K3G64_RS08925 (K3G64_08865) 1645624..1647018 + 1395 WP_238949217.1 acyl-CoA desaturase -
K3G64_RS08930 (K3G64_08870) 1647055..1648002 - 948 WP_238950530.1 glycoside hydrolase family 6 protein -
K3G64_RS08935 (K3G64_08875) 1648128..1648382 + 255 WP_238949219.1 antitoxin Antitoxin
K3G64_RS08940 (K3G64_08880) 1648379..1648819 + 441 WP_238949223.1 type II toxin-antitoxin system VapC family toxin Toxin
K3G64_RS08945 (K3G64_08885) 1648906..1649148 + 243 WP_238949225.1 hypothetical protein -
K3G64_RS08950 (K3G64_08890) 1649243..1650271 + 1029 WP_238949227.1 fused (3R)-hydroxyacyl-ACP dehydratase subunits HadA/HadB -
K3G64_RS08955 (K3G64_08895) 1650445..1651833 + 1389 WP_238949228.1 wax ester/triacylglycerol synthase family O-acyltransferase -
K3G64_RS08960 (K3G64_08900) 1651830..1652486 - 657 WP_238950531.1 DsbA family protein -
K3G64_RS08965 (K3G64_08905) 1652573..1653709 - 1137 WP_238949235.1 cellulase family glycosylhydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-133)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 147 a.a.        Molecular weight: 15575.63 Da        Isoelectric Point: 5.4627

>T212436 WP_238949223.1 NZ_CP081006:1648379-1648819 [Mycobacterium sp. IDR2000157661]
VKVVDASILLYSVNSASEHHEACREWLDGALSGSDTVGLAWVPLLAFVRLSTKVGLFPSPLPPSEAMRQVVDWSTAPGAT
VIAPTPRHGDILHGLLANVGTGGNLVNDAHLAALTIEHRASIVSYDNDFGRFDGIRWDTPDALLAR

Download         Length: 441 bp

>T212436 NZ_CP107017:c45951-45535 [Klebsiella pneumoniae]
GTGAACAAGACCTATATGCTCGACACCTGTATCTGCTCGTTCATCATGCGCGAGCAGCCGGAAGCCGTCCTGAAGCGCCT
GGAGCAGGCGGTGCTGCGCGGCCAGCGCATCGTTGTCTCGGCCATCACTTATTCTGAAATGCGCTTCGGGGCCACCGGCC
CGAAGGCCTCCCCGCGCCACGTCGAGCTGGTCGACGCGTTCTGCGCCCGCCTCGATGCCATCCTGCCCTGGGATCGCGCT
GCGGTGGACGCCACCACGGAGATTAAGGTGGCGCTGCGAATGGCCGGGACGCCGATCGGCCCGAACGACACGGCCATTGC
CGGGCACGCCATCGCCGCCGGTGCCGTGCTGGTGACGAATAATACGCGGGAATTTGAGCGGGTACCGGGTCTTGTGCTGG
AAGACTGGGTAAGATAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9438.72 Da        Isoelectric Point: 10.9716

>AT212436 WP_238949219.1 NZ_CP081006:1648128-1648382 [Mycobacterium sp. IDR2000157661]
MRTTVTLDDDTLALIRRRMREQGVSFKTALNDAIRDGAFGRPPATRFVTRSADLGVPTVNLDRALQIAGELEDEELLRRQ
RRGA

Download         Length: 255 bp

>AT212436 NZ_CP107017:c46178-45948 [Klebsiella pneumoniae]
ATGAGAACTGTATCCATTTTTAAAAACGGCAATAACCGCGCCATTCGTCTGCCCCGCGATCTGGATTTTGAGGGAGTGAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATTATTTTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGTTCG
AGAAGGCAGACCCGGACTTTATGGCGGAGCGCGAGGACGTTGTCAGCGACGAAGGACGATTTAACCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References