Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 866846..867486 Replicon chromosome
Accession NZ_CP081006
Organism Mycobacterium sp. IDR2000157661

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag K3G64_RS05020 Protein ID WP_238889412.1
Coordinates 866846..867232 (-) Length 129 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag K3G64_RS05025 Protein ID WP_238889413.1
Coordinates 867232..867486 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K3G64_RS04995 (K3G64_04960) 862260..863993 - 1734 WP_238889408.1 DUF4407 domain-containing protein -
K3G64_RS05000 (K3G64_04965) 864171..864566 - 396 WP_238889409.1 PIN domain-containing protein -
K3G64_RS05005 (K3G64_04970) 864563..864790 - 228 WP_238889410.1 antitoxin -
K3G64_RS05010 (K3G64_04975) 864873..866492 + 1620 WP_238889411.1 peptide chain release factor 3 -
K3G64_RS05015 (K3G64_04980) 866521..866730 - 210 Protein_804 PIN domain-containing protein -
K3G64_RS05020 (K3G64_04985) 866846..867232 - 387 WP_238889412.1 type II toxin-antitoxin system VapC family toxin Toxin
K3G64_RS05025 (K3G64_04990) 867232..867486 - 255 WP_238889413.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
K3G64_RS05030 (K3G64_04995) 867644..868795 - 1152 WP_238889414.1 serine hydrolase domain-containing protein -
K3G64_RS05035 (K3G64_05000) 869104..869641 + 538 Protein_808 glutamate synthase-related protein -
K3G64_RS05040 (K3G64_05005) 869735..869890 - 156 WP_238889415.1 hypothetical protein -
K3G64_RS05045 (K3G64_05010) 870526..871524 - 999 WP_238889416.1 AAA family ATPase -
K3G64_RS05050 (K3G64_05015) 871521..872183 - 663 WP_238889417.1 nicotinamide riboside transporter PnuC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 864563..887605 23042


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-124)

Antitoxin

Antitoxin VapB-like

(1-83)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 13862.59 Da        Isoelectric Point: 4.2876

>T212435 WP_238889412.1 NZ_CP081006:c867232-866846 [Mycobacterium sp. IDR2000157661]
MVIDTSALVAMLSDEPEADVFEAAVEADGTRLMSTASYLETAIVIETRFGEPGGRELDLWLHRAAVELVAVDAGQVEVAR
VAYRTYGKGRHRAALNYGDCFSYALAKVSNQPLLFKGDDFAQTDIGGF

Download         Length: 387 bp

>T212435 NZ_CP107016:123273-123560 [Klebsiella pneumoniae]
ATGAGGTATCAGGTAAAATTCAGGGAAGATGCGCTGAAAGAGTGGCAAAAAATGGACAAGACTATTCAGCAACAGTTTGC
GAAAAAGCTAAAAAAGTGCTGCGACAATCCGCATATTCCTTCCGCAAAACTGCGCGGGATAAAGGACTGCTACAAAATAA
AATTACGTGCGTCAGGTTTTCGCCTGGTCTATCAGGTGATTGACGAACAATTAATTATCGCTGTTGTAGCTGTGGGTAAA
CGTGAGCGCAGTGACGTTTATAATCTTGCCAGTGAAAGAATGAGATAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9284.59 Da        Isoelectric Point: 6.3498

>AT212435 WP_238889413.1 NZ_CP081006:c867486-867232 [Mycobacterium sp. IDR2000157661]
MALSIKDPEADRLARELSARTGESLTEAVLVALRERLARETGRTRSIPLREELAAIRRRCAALPVVDNRSADEILGYDDR
GLPA

Download         Length: 255 bp

>AT212435 NZ_CP107016:123025-123276 [Klebsiella pneumoniae]
ATGCCTAACATTATTCTCAGTGATACAAGCGCCAGTGTCAGCGAGCTGAAGAAAAATCCGATGGCGACAGTCAGCGCCGG
TGATGGTTTCCCGGTCGCTATCCTGAACCGTAATCAGCCTGCTTTCTACTGTGTACCCGCAGAGCTGTACGAAAAGATGC
TCGATGCCCTGGACGATCAGGAGCTGGTTAAACTGGTAGCCGAACGCAGCAACCAACCGCTGCATGATGTAGACCTGGAT
AAATACCTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References