Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 124556..125172 Replicon plasmid p20-157661
Accession NZ_CP081005
Organism Mycobacterium sp. IDR2000157661

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag K3G64_RS00600 Protein ID WP_238884887.1
Coordinates 124556..124903 (-) Length 116 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag K3G64_RS00605 Protein ID WP_238884726.1
Coordinates 124906..125172 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K3G64_RS00580 (K3G64_00580) 120973..121704 + 732 WP_238884719.1 hypothetical protein -
K3G64_RS00585 (K3G64_00585) 121809..122570 - 762 WP_238884720.1 hypothetical protein -
K3G64_RS00590 (K3G64_00595) 123073..123735 + 663 WP_238884723.1 Fic family protein -
K3G64_RS00595 (K3G64_00600) 123790..124491 - 702 WP_238884725.1 hypothetical protein -
K3G64_RS00600 (K3G64_00605) 124556..124903 - 348 WP_238884887.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
K3G64_RS00605 (K3G64_00610) 124906..125172 - 267 WP_238884726.1 antitoxin Antitoxin
K3G64_RS00610 (K3G64_00615) 125914..126165 + 252 WP_238884728.1 helix-turn-helix domain-containing protein -
K3G64_RS00615 (K3G64_00620) 126448..127947 + 1500 WP_238884730.1 IS21 family transposase -
K3G64_RS00620 (K3G64_00625) 127944..128741 + 798 Protein_123 IS21-like element helper ATPase IstB -
K3G64_RS00625 (K3G64_00630) 129198..129551 - 354 WP_011891521.1 DUF732 domain-containing protein -
K3G64_RS00630 (K3G64_00635) 129563..130051 - 489 WP_011891522.1 cupin domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..191242 191242


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(5-98)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 12316.01 Da        Isoelectric Point: 9.9859

>T212433 WP_238884887.1 NZ_CP081005:c124903-124556 [Mycobacterium sp. IDR2000157661]
VTPARGQVYRCDLGYGAKPWLIVSNNQRNRHTADVVAIRLTTTSRRLPTWVALASSDPLTGYANADNIETLAKDELGDYL
GALSPATMARVNTALAIALALPAGRSPRPQPPPTH

Download         Length: 348 bp

>T212433 NZ_CP107015:123110-123421 [Klebsiella pneumoniae]
ATGCACGTAATTTCAAAAGAGCCTTTTGAGGAAGCGGCAAAGCGATATCCCAACGATTCGTTAGCCATTCGGGCGTTGTA
CCGCTTAGTGCGCGAGACGGACTTCTCTTCTCCAGCTGAGATGCTAACTCTGATACCGAGCCTGGATAATTTTAAGTACA
GGAATAAGTGGTGGGTTTTGGATGTAGGGGGCAACAACTTAAGGGTTATCGCCTATATCAATTTCGTAAATAAGCGCTTC
TACGTGAAGCACATCGCAACCCACGCTGATTACGACAAGTTGACCCGCTATTACAGGGAGAACAAAGAATGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9917.91 Da        Isoelectric Point: 6.7173

>AT212433 WP_238884726.1 NZ_CP081005:c125172-124906 [Mycobacterium sp. IDR2000157661]
MAEEYSTRLRLDASTHQRLQDIVGKGHYRSSNAAIVDAINRLWDHVCEQELDAAYAAAVAENPSYPYESVAERAAARARR
NRRQAVSE

Download         Length: 267 bp

>AT212433 NZ_CP107015:123418-123837 [Klebsiella pneumoniae]
ATGATTACCGACACTGCAAAAGCCATTGAAGCAACCAAACAACTCGTAGCTGCCGTCCCCTTCCTAGGGGGCAGTTCTTC
CGAGAGCGATTACCGCGAAGCGATGGAGCTGGTGGATTATCTGATCGAGAACGACGACGAGAACCCACTTATTGACTTCC
TGGCGAGTAAGATTGCCGACTATGAAGATAACAGCCCTCGTTTCGCTGAGTTCAACAAAGCTATTGCTGAAATACCAGTC
GGCGTTGCACTTCTGCGAACCCTGATTGACCAGCACAAGCTGTCTTATTCAGACCTTAAGGATGAGATCGGATCTAAATC
ATTGGTCAGCCAAATCCTGTCAGGGCAGCGCTCTTTGACCATCACTCACATAAAAGCTCTTTCCGCGCGCTTCGGTGTAA
AACCTGAGTGGTTCCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References