Detailed information of TA system TA212432

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ParST/RES-Xre
• Location: 882154..883115
• Replicon: plasmid unnamed1
• Accession: NZ_CP081002
• Organism: Sphingobium sp. V4

Toxin (Protein)

• Gene name: ParT
• Uniprot ID: -
• Locus tag: K3M67_RS19785
• Protein ID: WP_285833117.1
• Coordinates: 882154..882639 (-)
• Length: 162 a.a.

Antitoxin (Protein)

• Gene name: ParS
• Uniprot ID: -
• Locus tag: K3M67_RS19790
• Protein ID: WP_285833118.1
• Coordinates: 882636..883115 (-)
• Length: 160 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K3M67_RS19755 (K3M67_19755)	877574..877993	+	420	WP_285833113.1	hypothetical protein	-
K3M67_RS19760 (K3M67_19760)	878244..878420	+	177	Protein_758	transcriptional regulator	-
K3M67_RS19765 (K3M67_19765)	878517..879305	+	789	WP_285833738.1	GntR family transcriptional regulator	-
K3M67_RS19770 (K3M67_19770)	879465..879599	+	135	WP_285833114.1	benenodin family lasso peptide	-
K3M67_RS19775 (K3M67_19775)	879665..880318	+	654	WP_285833115.1	lasso peptide biosynthesis B2 protein	-
K3M67_RS19780 (K3M67_19780)	880318..882078	+	1761	WP_285833116.1	asparagine synthase-related protein	-
K3M67_RS19785 (K3M67_19785)	882154..882639	-	486	WP_285833117.1	RES family NAD+ phosphorylase	Toxin
K3M67_RS19790 (K3M67_19790)	882636..883115	-	480	WP_285833118.1	DUF2384 domain-containing protein	Antitoxin
K3M67_RS19795 (K3M67_19795)	883203..885113	-	1911	WP_285833119.1	Atxe2 family lasso peptide isopeptidase	-
K3M67_RS19800 (K3M67_19800)	885287..887857	-	2571	WP_285833120.1	TonB-dependent receptor	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..1247975	1247975

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (5-151)

Antitoxin

• Antitoxin Xre-like, helix-turn-helix domain (31-92)

Sequences

Toxin

Protein

• Length: 162 a.a.
• Molecular weight: 17263.81 Da
• Isoelectric Point: 7.1663

>T212432 WP_285833117.1 NZ_CP081002:c882639-882154 [Sphingobium sp. V4]
VTTSFWRIATDTKAYEADDMTGAGAKITGGRWNDVGIALVYAASNRALACLETVVHLNSGGLPLNRFLVEIAVPDDMLAA
AEFATGGSLAVGWDAEPAGRVSISFGSAWAQSLRTALMLVPSVIVPEEQNLLINPAHPDAGRITARKVRKWLYDPRMIRK
A

Nucleotide

• Length: 486 bp

>T212432 NZ_CP107015:76259-76729 [Klebsiella pneumoniae]
GTGATCCTCTACAGGCTGACGAAAACAAAGTATCTTTCTACGGCCTGGACCGGATATGGTGCGAAAGAGGCTGGTGGGCG
TTGGAATAGCGTGGGGGTGTCAATGGTATATGTCTCCGAAACGGCATCACTAACGATGCTGGAGACGCTGGTACACCTGC
ATGCGGCACAGATAATGGACTCTTTCACGCTACTGAGTATCGATGTGCCTGATGAACTGATCCAAAGCGCAAACATGGAT
GAATTACCGGGCAACTGGGCTGATGAGGATGCGCCTCAGGAACTGGCTGATTACGGAGATGCCTGGTCATTTACCAGGAG
CTCGGTTGCACTGCGTGTTCCCTCAGCCTTATCGCCGGTAGAGTTCAACTATCTGTTAAATCCTGAGCACCCTGAGTTTT
ACGGGATCGTGCAGAAGGCTCAACAGATACCGTTCCGGTTTGATAGTCGTCTTAAACCTGACAGGAAGTGA

Antitoxin

Protein

• Length: 160 a.a.
• Molecular weight: 17436.02 Da
• Isoelectric Point: 8.4926

>AT212432 WP_285833118.1 NZ_CP081002:c883115-882636 [Sphingobium sp. V4]
MSEVEVGRRKPQGKNPPPFAYKALYRASPVDRIGFIKKGVAARDLKRFIVALHVDQKVMFNALNLKTATVNKKAANNQPL
STEDSERVLGLAKLVGQLEDMVEESGDAEGFDAPEWFSTWLRQPLPALAGVNPIDLLDTMEGQALVSRTLAQIQSGTFA

Nucleotide

• Length: 480 bp

>AT212432 NZ_CP107015:75819-76262 [Klebsiella pneumoniae]
ATGAAAACATTTAGTTTGTCCTCAACTCCAGCCAGACCACAGCGCCTCTGGCAGGTTGCCGGGTTAAATAATGCTGATGG
CGTAGCGCTTCTGGGCCAAATCAATGAAGGCCTGGACGGGAAGGTGGCGAATCGGATCACTGACTGGGCCAGAATAACCC
AGAATGACCTGAGAAAAATGTCCGGTATCCCGTCGACCACGTTTAGCCGCAGTGTGAAGGCACGTTTTAACCCGGAACAA
AGTGAACGTCTGGTACGGATTATCCGCGTCATTGATCGGGCGGTAGATTTGTTTGAAGGCGACAAGGAAGCCGCACAGAA
GTGGTTGAACGAACCTAACCGGGCATTGAGCTGGAAAGTGCCAGCAGACCTGATGGCATCCGAGACAGGAGCGTATGAGG
TCATTAAGCTGATTACGCGTCTGGAGCATGGGGTGTACTCGTGA