Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pezAT/zeta-ParD
Location 2823668..2824673 Replicon chromosome
Accession NZ_CP081000
Organism Mycolicibacterium senegalense strain ATCC 35796

Toxin (Protein)


Gene name pezT Uniprot ID A0A378T131
Locus tag K3U95_RS13200 Protein ID WP_036387328.1
Coordinates 2824095..2824673 (+) Length 193 a.a.

Antitoxin (Protein)


Gene name pezA Uniprot ID A0A378T1G9
Locus tag K3U95_RS13195 Protein ID WP_019346253.1
Coordinates 2823668..2824057 (+) Length 130 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K3U95_RS13180 (K3U95_13180) 2820292..2820702 - 411 WP_019346256.1 transglycosylase family protein -
K3U95_RS13185 (K3U95_13185) 2821101..2822456 - 1356 WP_036387332.1 alpha/beta hydrolase-fold protein -
K3U95_RS13190 (K3U95_13190) 2822584..2823600 + 1017 WP_036387331.1 TIGR03617 family F420-dependent LLM class oxidoreductase -
K3U95_RS13195 (K3U95_13195) 2823668..2824057 + 390 WP_019346253.1 hypothetical protein Antitoxin
K3U95_RS13200 (K3U95_13200) 2824095..2824673 + 579 WP_036387328.1 zeta toxin family protein Toxin
K3U95_RS13205 (K3U95_13205) 2824694..2826949 - 2256 WP_036387327.1 catalase/peroxidase HPI -
K3U95_RS13210 (K3U95_13210) 2826985..2827416 - 432 WP_036387326.1 Fur family transcriptional regulator -
K3U95_RS13215 (K3U95_13215) 2827507..2828142 + 636 WP_036387324.1 FKBP-type peptidyl-prolyl cis-trans isomerase -
K3U95_RS13220 (K3U95_13220) 2828195..2828800 + 606 WP_036387323.1 class I SAM-dependent methyltransferase -
K3U95_RS13225 (K3U95_13225) 2828754..2829593 - 840 WP_109531017.1 thioesterase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(4-140)

Antitoxin

ParD-like antitoxin of type II bacterial toxin-antitoxin system

(6-106)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 20912.01 Da        Isoelectric Point: 7.0515

>T212429 WP_036387328.1 NZ_CP081000:2824095-2824673 [Mycolicibacterium senegalense]
VKRLDLVVGCNGAGKSTFVELTLSPLLPGSPFVNADEIAKRRWPEDPAPHSYEAALIAAETRAKLIELGESFIAETVFSH
PSKLDLIDDAHVAGYTVVLHCILIPEELAVQRVRHRVSAGGHDVPEAKIRERYQRLWDLVAVAAMRADAATFYDNSTVRG
PRIVAQIAGGFAIGSPTWPKWAPAVLISRWAG

Download         Length: 579 bp

>T212429 NZ_CP107014:c4994306-4993389 [Klebsiella pneumoniae]
ATGGATATACAGGCGCCTTATTATCGGCAGGTTGCTCTGCTAATGCAGGTTTTACCCTATGTTGCTGTCGAACGGGAATT
TGCGCTGAAAGGTGGCACTGCCATCAATCTCTTTATCCGCGATTTCCCTCGATTATCGGTGGATATCGACCTCGCCTGGG
TGCCCCTGGAAAGCAGAGCCATCGCTTTACCTCATATACGGGATGCGCTTGCACGTATTGCCGCCAATCTGCAACAACAG
GCAGGTATGAGCGCTGTATTACAAGCTAATCGTTCAGATGAGATGCGTGTCATTGTTACTACCGATAGCGCGCAAATAAA
GATAGAGGTTTCACCGGTCGCCCGGGGAACATTATATCCACCACAGGAGCGAGAAGTGGTGGGGGCGGTAGAGGACGTTT
TTGGCTATGCCAGCCTTCCAGTGGTTTCGTTGCCTGACCTCTACGGTGGAAAATTATGCGCGGCGCTGGATCGCCAGCAT
CCCAGAGATTTTTATGACGTGAAATTACTTCTTGATGCGCAGGAGCTTGACCGTCCCATTTTCAATGGGTTTATCGTGTA
TTTACTGAGCCATAATCGGCCTCTGGCTGAAGTGCTGAATCCTCGCTGGAAAGATATTGCTGAACCTTTTTACCGTGAAT
TCAGCGGGATGACATTTGAGACGATAGCCCTGGAGGAACTGACAGCAGTCCCCAACAGGATGATTGCTGCGTTAAAATCC
TGTTTCACACAACAGGATGTCGATTTTTTACTGTCATTTAAACGAGGCGAACCAGACTGGCGTTTAGCGCCGGAAATGCG
TATTCAGGATTTGCCTGCCGTGCAGTGGAAATTGCGCAATATTCATCAGATGCCAGCGATAAAACGCGCTGAGTCATTAG
ATAAACTGGAAAAGGTGCTGGCCGAGTGGCGCAGTTAG

Antitoxin


Download         Length: 130 a.a.        Molecular weight: 13745.15 Da        Isoelectric Point: 5.2329

>AT212429 WP_019346253.1 NZ_CP081000:2823668-2824057 [Mycolicibacterium senegalense]
MTETADRVTRFAADLIDSAAAEGARQSRSAKQQLDHWARVGRAVSSQHSAARRKVESALAGELSLRELTAEEGTVFDAEI
AASIEESLARADYGKTLAGRGITTVALDDNGNIVQYRPDGSTAVLARTQ

Download         Length: 390 bp

>AT212429 NZ_CP107014:c4995070-4994312 [Klebsiella pneumoniae]
ATGGCAACAAAATTAAACTGGCTGCTGCAAAACAGCGCTCCCGGAGATGTGATCCTTCAGTCCTGGTTAAGCCAGCATGC
CATCTCTCCCTCTCTGTCCTTTAAATACGCGCAAAGTGGCTGGTTAAAAAAAAGAGGCAACGGCGTATATGCGCGTGCGG
GACGTGAGCCGGAGTGGAACGATGCATTAGCATGTTTGCAAAATCAGCTTGCCGCTCCGGTGTATGTTGCGGGGCTCAGT
AGCTTAGTCTGGCAGGGCCGTTCACACTATCTACAGCTAAAACAAAACCAGTGCTGGCTTAGTGTGGAAAATAAAGCGCT
GCTGCCGAAATGGTTCAGGGAATTCCCGGGTGTGGAGTGGATAGTCATATCGGGGAAAAAACTGCCGGTGCTGGATGATA
GATACCGTGTAACGCTTGATATAAAAGGGAAAAAACTCATCGGCAGTGCGCCAGAACTGGCTGCTTACGAGTTGCTGAGC
GCGGTGCCGGGGACCCTCTCATTTAACCACGCTGCAGAGCTTTTCCAGGGGCTGGTTAATCTTAATCCTCGTAAAGTAGA
GTATCTTCTTTCCGTCAGCCAGTCCGTGCAGGCCAAGCGTTTGTATCTCTTCTTCGCCAGTTTTTACGAGCATGGCTGGC
TCAAACGAATCGATAGCCAAAAAATCGATCTGGGAGCGGGCAAGCGGCAAATCGTGGAAAATGGAAAGTTCAATGCTCAA
TACCAAATCACAGTGCCTGAACGCTTTCAAAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A378T131

Antitoxin

Source ID Structure
AlphaFold DB A0A378T1G9

References