Detailed information of TA system TA212427

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/LOTUS_5_Limkain_b1-PHD
• Location: 4440906..4441549
• Replicon: chromosome
• Accession: NZ_CP080999
• Organism: Mycobacterium malmoense strain ATCC 29571

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: K3U93_RS20390
• Protein ID: WP_071509157.1
• Coordinates: 4440906..4441295 (-)
• Length: 130 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: K3U93_RS20395
• Protein ID: WP_083011961.1
• Coordinates: 4441292..4441549 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	4437583..4455044	17461

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (8-121)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (4-50)

Sequences

Toxin

Protein

• Length: 130 a.a.
• Molecular weight: 14085.00 Da
• Isoelectric Point: 4.5242

>T212427 WP_071509157.1 NZ_CP080999:c4441295-4440906 [Mycobacterium malmoense]
VMVRRALADTSIFIGIEAARFDDDRFTEHEWGVSVITLGELRLGVLQASDPDTAARRLSTYQLAQRFEPLSIDETVSEAW
ALLVSKRAANLRAPINDSWIAATAMAHGIPIVTQGSDYSAMPGVEVITI

Nucleotide

• Length: 390 bp

>T212427 NZ_CP107014:c4734445-4733912 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGTGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAAGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9678.07 Da
• Isoelectric Point: 6.3620

>AT212427 WP_083011961.1 NZ_CP080999:c4441549-4441292 [Mycobacterium malmoense]
MAATIPARDLRNRTAEVLRRVAAGEEIEVLKDNRPVARIVPLTRRRQWLPAAEVIGELMRLGPDTTNLSEELRETLTRTT
DDVSW

Nucleotide

• Length: 258 bp

>AT212427 NZ_CP107014:c4734722-4734456 [Klebsiella pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA