Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-PHD
Location 4440906..4441549 Replicon chromosome
Accession NZ_CP080999
Organism Mycobacterium malmoense strain ATCC 29571

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag K3U93_RS20390 Protein ID WP_071509157.1
Coordinates 4440906..4441295 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag K3U93_RS20395 Protein ID WP_083011961.1
Coordinates 4441292..4441549 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K3U93_RS20355 (K3U93_20355) 4436805..4437086 - 282 WP_139797163.1 hypothetical protein -
K3U93_RS20360 (K3U93_20360) 4437370..4437909 + 540 WP_139797162.1 hypothetical protein -
K3U93_RS20365 (K3U93_20365) 4437921..4438142 + 222 WP_071508759.1 DUF4926 domain-containing protein -
K3U93_RS20370 (K3U93_20370) 4438248..4438492 - 245 Protein_4060 SAM-dependent methyltransferase -
K3U93_RS20375 (K3U93_20375) 4439229..4439693 - 465 Protein_4061 hypothetical protein -
K3U93_RS20380 (K3U93_20380) 4440059..4440346 + 288 WP_176220053.1 DUF1778 domain-containing protein -
K3U93_RS20385 (K3U93_20385) 4440599..4440919 + 321 WP_083011963.1 GNAT family N-acetyltransferase -
K3U93_RS20390 (K3U93_20390) 4440906..4441295 - 390 WP_071509157.1 type II toxin-antitoxin system VapC family toxin Toxin
K3U93_RS20395 (K3U93_20395) 4441292..4441549 - 258 WP_083011961.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
K3U93_RS20400 (K3U93_20400) 4441699..4442421 + 723 WP_139797161.1 hypothetical protein -
K3U93_RS20405 (K3U93_20405) 4442414..4443193 + 780 WP_083011956.1 hypothetical protein -
K3U93_RS20410 (K3U93_20410) 4443205..4443455 - 251 Protein_4068 hypothetical protein -
K3U93_RS20415 (K3U93_20415) 4443787..4444728 - 942 WP_083011953.1 class I SAM-dependent methyltransferase -
K3U93_RS20420 (K3U93_20420) 4444731..4445672 - 942 WP_083012006.1 class I SAM-dependent methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4437583..4455044 17461


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(8-121)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(4-50)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 14085.00 Da        Isoelectric Point: 4.5242

>T212427 WP_071509157.1 NZ_CP080999:c4441295-4440906 [Mycobacterium malmoense]
VMVRRALADTSIFIGIEAARFDDDRFTEHEWGVSVITLGELRLGVLQASDPDTAARRLSTYQLAQRFEPLSIDETVSEAW
ALLVSKRAANLRAPINDSWIAATAMAHGIPIVTQGSDYSAMPGVEVITI

Download         Length: 390 bp

>T212427 NZ_CP107014:c4734445-4733912 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGTGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAAGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9678.07 Da        Isoelectric Point: 6.3620

>AT212427 WP_083011961.1 NZ_CP080999:c4441549-4441292 [Mycobacterium malmoense]
MAATIPARDLRNRTAEVLRRVAAGEEIEVLKDNRPVARIVPLTRRRQWLPAAEVIGELMRLGPDTTNLSEELRETLTRTT
DDVSW

Download         Length: 258 bp

>AT212427 NZ_CP107014:c4734722-4734456 [Klebsiella pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References