Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vapBC/VapC(toxin) |
Location | 4390000..4390640 | Replicon | chromosome |
Accession | NZ_CP080999 | ||
Organism | Mycobacterium malmoense strain ATCC 29571 |
Toxin (Protein)
Gene name | vapC | Uniprot ID | - |
Locus tag | K3U93_RS20120 | Protein ID | WP_083011411.1 |
Coordinates | 4390242..4390640 (+) | Length | 133 a.a. |
Antitoxin (Protein)
Gene name | vapB | Uniprot ID | - |
Locus tag | K3U93_RS20115 | Protein ID | WP_071510511.1 |
Coordinates | 4390000..4390245 (+) | Length | 82 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
K3U93_RS20100 (K3U93_20100) | 4386414..4388006 | - | 1593 | WP_083011413.1 | serine hydrolase | - |
K3U93_RS20105 (K3U93_20105) | 4388026..4389141 | - | 1116 | WP_083011412.1 | MBL fold metallo-hydrolase | - |
K3U93_RS20110 (K3U93_20110) | 4389147..4389875 | - | 729 | WP_071510510.1 | enoyl-CoA hydratase | - |
K3U93_RS20115 (K3U93_20115) | 4390000..4390245 | + | 246 | WP_071510511.1 | type II toxin-antitoxin system VapB family antitoxin | Antitoxin |
K3U93_RS20120 (K3U93_20120) | 4390242..4390640 | + | 399 | WP_083011411.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
K3U93_RS20125 (K3U93_20125) | 4390727..4392199 | + | 1473 | WP_083011410.1 | carboxyl transferase domain-containing protein | - |
K3U93_RS20130 (K3U93_20130) | 4392505..4393668 | - | 1164 | WP_139797096.1 | hypothetical protein | - |
K3U93_RS20135 (K3U93_20135) | 4394242..4394757 | - | 516 | WP_071510515.1 | GNAT family N-acetyltransferase | - |
K3U93_RS20140 (K3U93_20140) | 4394758..4395036 | - | 279 | WP_230981487.1 | DUF1778 domain-containing protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 133 a.a. Molecular weight: 14140.83 Da Isoelectric Point: 4.0492
>T212426 WP_083011411.1 NZ_CP080999:4390242-4390640 [Mycobacterium malmoense]
VIVDTSAVIAILTEEDDAAVYAEALAGADTCRLSAASYLECGIVLDSQRDPIISRALDELMQEAQCVVEPVTERQARLAR
QAYADFGKGSGHPAGLNFGDCLSYALASDLREPLLWKGNDFGYTGIRSALDQ
VIVDTSAVIAILTEEDDAAVYAEALAGADTCRLSAASYLECGIVLDSQRDPIISRALDELMQEAQCVVEPVTERQARLAR
QAYADFGKGSGHPAGLNFGDCLSYALASDLREPLLWKGNDFGYTGIRSALDQ
Download Length: 399 bp
>T212426 NZ_CP107014:4120557-4120775 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA
Antitoxin
Download Length: 82 a.a. Molecular weight: 8836.10 Da Isoelectric Point: 9.9250
>AT212426 WP_071510511.1 NZ_CP080999:4390000-4390245 [Mycobacterium malmoense]
MALNIKDASIHEAVKQIAKITGESQTQAVATAVQERLARLQRDDLTARILAIGHKTAGRMSSETKQLDHATLLYDQRGLP
A
MALNIKDASIHEAVKQIAKITGESQTQAVATAVQERLARLQRDDLTARILAIGHKTAGRMSSETKQLDHATLLYDQRGLP
A
Download Length: 246 bp
>AT212426 NZ_CP107014:4120156-4120530 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
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Antitoxin
Source | ID | Structure |
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