Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 4390000..4390640 Replicon chromosome
Accession NZ_CP080999
Organism Mycobacterium malmoense strain ATCC 29571

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag K3U93_RS20120 Protein ID WP_083011411.1
Coordinates 4390242..4390640 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag K3U93_RS20115 Protein ID WP_071510511.1
Coordinates 4390000..4390245 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K3U93_RS20100 (K3U93_20100) 4386414..4388006 - 1593 WP_083011413.1 serine hydrolase -
K3U93_RS20105 (K3U93_20105) 4388026..4389141 - 1116 WP_083011412.1 MBL fold metallo-hydrolase -
K3U93_RS20110 (K3U93_20110) 4389147..4389875 - 729 WP_071510510.1 enoyl-CoA hydratase -
K3U93_RS20115 (K3U93_20115) 4390000..4390245 + 246 WP_071510511.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
K3U93_RS20120 (K3U93_20120) 4390242..4390640 + 399 WP_083011411.1 type II toxin-antitoxin system VapC family toxin Toxin
K3U93_RS20125 (K3U93_20125) 4390727..4392199 + 1473 WP_083011410.1 carboxyl transferase domain-containing protein -
K3U93_RS20130 (K3U93_20130) 4392505..4393668 - 1164 WP_139797096.1 hypothetical protein -
K3U93_RS20135 (K3U93_20135) 4394242..4394757 - 516 WP_071510515.1 GNAT family N-acetyltransferase -
K3U93_RS20140 (K3U93_20140) 4394758..4395036 - 279 WP_230981487.1 DUF1778 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-121)

Antitoxin

Antitoxin VapB-like

(1-80)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14140.83 Da        Isoelectric Point: 4.0492

>T212426 WP_083011411.1 NZ_CP080999:4390242-4390640 [Mycobacterium malmoense]
VIVDTSAVIAILTEEDDAAVYAEALAGADTCRLSAASYLECGIVLDSQRDPIISRALDELMQEAQCVVEPVTERQARLAR
QAYADFGKGSGHPAGLNFGDCLSYALASDLREPLLWKGNDFGYTGIRSALDQ

Download         Length: 399 bp

>T212426 NZ_CP107014:4120557-4120775 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8836.10 Da        Isoelectric Point: 9.9250

>AT212426 WP_071510511.1 NZ_CP080999:4390000-4390245 [Mycobacterium malmoense]
MALNIKDASIHEAVKQIAKITGESQTQAVATAVQERLARLQRDDLTARILAIGHKTAGRMSSETKQLDHATLLYDQRGLP
A

Download         Length: 246 bp

>AT212426 NZ_CP107014:4120156-4120530 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References