Detailed information of TA system TA212426

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC(toxin)
• Location: 4390000..4390640
• Replicon: chromosome
• Accession: NZ_CP080999
• Organism: Mycobacterium malmoense strain ATCC 29571

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: K3U93_RS20120
• Protein ID: WP_083011411.1
• Coordinates: 4390242..4390640 (+)
• Length: 133 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: K3U93_RS20115
• Protein ID: WP_071510511.1
• Coordinates: 4390000..4390245 (+)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (1-121)

Antitoxin

• Antitoxin VapB-like (1-80)

Sequences

Toxin

Protein

• Length: 133 a.a.
• Molecular weight: 14140.83 Da
• Isoelectric Point: 4.0492

>T212426 WP_083011411.1 NZ_CP080999:4390242-4390640 [Mycobacterium malmoense]
VIVDTSAVIAILTEEDDAAVYAEALAGADTCRLSAASYLECGIVLDSQRDPIISRALDELMQEAQCVVEPVTERQARLAR
QAYADFGKGSGHPAGLNFGDCLSYALASDLREPLLWKGNDFGYTGIRSALDQ

Nucleotide

• Length: 399 bp

>T212426 NZ_CP107014:4120557-4120775 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 8836.10 Da
• Isoelectric Point: 9.9250

>AT212426 WP_071510511.1 NZ_CP080999:4390000-4390245 [Mycobacterium malmoense]
MALNIKDASIHEAVKQIAKITGESQTQAVATAVQERLARLQRDDLTARILAIGHKTAGRMSSETKQLDHATLLYDQRGLP
A

Nucleotide

• Length: 246 bp

>AT212426 NZ_CP107014:4120156-4120530 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG