Detailed information of TA system TA212425

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): unclassified/Polyketide_cyc2(toxin)
• Location: 4383311..4383974
• Replicon: chromosome
• Accession: NZ_CP080999
• Organism: Mycobacterium malmoense strain ATCC 29571

Toxin (Protein)

• Gene name: novel[antitoxin]
• Uniprot ID: -
• Locus tag: K3U93_RS20085
• Protein ID: WP_083011414.1
• Coordinates: 4383311..4383781 (-)
• Length: 157 a.a.

Antitoxin (Protein)

• Gene name: novel[toxin]
• Uniprot ID: -
• Locus tag: K3U93_RS20090
• Protein ID: WP_071510531.1
• Coordinates: 4383786..4383974 (-)
• Length: 63 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K3U93_RS20060 (K3U93_20060)	4378729..4379967	+	1239	WP_254893618.1	MFS transporter	-
K3U93_RS20065 (K3U93_20065)	4379995..4381476	-	1482	WP_083011415.1	DUF4185 domain-containing protein	-
K3U93_RS20070 (K3U93_20070)	4381979..4382161	+	183	Protein_4000	carotenoid oxygenase family protein	-
K3U93_RS20075 (K3U93_20075)	4382342..4382818	+	477	WP_139797102.1	VOC family protein	-
K3U93_RS20080 (K3U93_20080)	4382823..4383248	-	426	WP_071510505.1	hypothetical protein	-
K3U93_RS20085 (K3U93_20085)	4383311..4383781	-	471	WP_083011414.1	SRPBCC family protein	Toxin
K3U93_RS20090 (K3U93_20090)	4383786..4383974	-	189	WP_071510531.1	antitoxin	Antitoxin
K3U93_RS20095 (K3U93_20095)	4384018..4386417	-	2400	WP_071510507.1	cation-translocating P-type ATPase	-
K3U93_RS20100 (K3U93_20100)	4386414..4388006	-	1593	WP_083011413.1	serine hydrolase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Polyketide cyclase/dehydrase (1-142)

Antitoxin

• Antitoxin Rv0909/MT0933 (4-52)

Sequences

Toxin

Protein

• Length: 157 a.a.
• Molecular weight: 17132.83 Da
• Isoelectric Point: 9.5924

>T212425 WP_083011414.1 NZ_CP080999:c4383781-4383311 [Mycobacterium malmoense]
MAKLSGSIDVPLPPEVAWKHASDLSRYREWLTIHRVWRSTLPDEIEKGTVIESIVEVKGMLNRIRWTVVHYKPPQGMTLN
GDGVGGVKVKLMAKIQPKDEGSVVGFDVHLGGPALFGPIGMIVAAALRSDINESLHNFVRVFTAPDPQMNGDGGRR

Nucleotide

• Length: 471 bp

>T212425 NZ_CP107014:c3289410-3289308 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin

Protein

• Length: 63 a.a.
• Molecular weight: 6605.29 Da
• Isoelectric Point: 5.0336

>AT212425 WP_071510531.1 NZ_CP080999:c4383974-4383786 [Mycobacterium malmoense]
VGFLDKAKDLLAQNADKVETAIDKAGEFVDGKTKGKYSDTIHKVQEEAKKAAESAGPGDQQN

Nucleotide

• Length: 189 bp

>AT212425 NZ_CP107014:3289301-3289446 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT