Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/Polyketide_cyc2(toxin)
Location 4383311..4383974 Replicon chromosome
Accession NZ_CP080999
Organism Mycobacterium malmoense strain ATCC 29571

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID -
Locus tag K3U93_RS20085 Protein ID WP_083011414.1
Coordinates 4383311..4383781 (-) Length 157 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID -
Locus tag K3U93_RS20090 Protein ID WP_071510531.1
Coordinates 4383786..4383974 (-) Length 63 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K3U93_RS20060 (K3U93_20060) 4378729..4379967 + 1239 WP_254893618.1 MFS transporter -
K3U93_RS20065 (K3U93_20065) 4379995..4381476 - 1482 WP_083011415.1 DUF4185 domain-containing protein -
K3U93_RS20070 (K3U93_20070) 4381979..4382161 + 183 Protein_4000 carotenoid oxygenase family protein -
K3U93_RS20075 (K3U93_20075) 4382342..4382818 + 477 WP_139797102.1 VOC family protein -
K3U93_RS20080 (K3U93_20080) 4382823..4383248 - 426 WP_071510505.1 hypothetical protein -
K3U93_RS20085 (K3U93_20085) 4383311..4383781 - 471 WP_083011414.1 SRPBCC family protein Toxin
K3U93_RS20090 (K3U93_20090) 4383786..4383974 - 189 WP_071510531.1 antitoxin Antitoxin
K3U93_RS20095 (K3U93_20095) 4384018..4386417 - 2400 WP_071510507.1 cation-translocating P-type ATPase -
K3U93_RS20100 (K3U93_20100) 4386414..4388006 - 1593 WP_083011413.1 serine hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Polyketide cyclase/dehydrase

(1-142)

Antitoxin

Antitoxin Rv0909/MT0933

(4-52)


Sequences

Toxin        


Download         Length: 157 a.a.        Molecular weight: 17132.83 Da        Isoelectric Point: 9.5924

>T212425 WP_083011414.1 NZ_CP080999:c4383781-4383311 [Mycobacterium malmoense]
MAKLSGSIDVPLPPEVAWKHASDLSRYREWLTIHRVWRSTLPDEIEKGTVIESIVEVKGMLNRIRWTVVHYKPPQGMTLN
GDGVGGVKVKLMAKIQPKDEGSVVGFDVHLGGPALFGPIGMIVAAALRSDINESLHNFVRVFTAPDPQMNGDGGRR

Download         Length: 471 bp

>T212425 NZ_CP107014:c3289410-3289308 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 63 a.a.        Molecular weight: 6605.29 Da        Isoelectric Point: 5.0336

>AT212425 WP_071510531.1 NZ_CP080999:c4383974-4383786 [Mycobacterium malmoense]
VGFLDKAKDLLAQNADKVETAIDKAGEFVDGKTKGKYSDTIHKVQEEAKKAAESAGPGDQQN

Download         Length: 189 bp

>AT212425 NZ_CP107014:3289301-3289446 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References