Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/AbrB(antitoxin)
Location 4147220..4147893 Replicon chromosome
Accession NZ_CP080999
Organism Mycobacterium malmoense strain ATCC 29571

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag K3U93_RS18970 Protein ID WP_083012383.1
Coordinates 4147220..4147657 (-) Length 146 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag K3U93_RS18975 Protein ID WP_071509811.1
Coordinates 4147654..4147893 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K3U93_RS18940 (K3U93_18940) 4143016..4143360 - 345 Protein_3777 hypothetical protein -
K3U93_RS18945 (K3U93_18945) 4143453..4143800 + 348 WP_139797194.1 hypothetical protein -
K3U93_RS18950 (K3U93_18950) 4143775..4144953 - 1179 WP_139797193.1 hypothetical protein -
K3U93_RS25040 4145465..4145854 - 390 WP_230981427.1 hypothetical protein -
K3U93_RS18955 (K3U93_18955) 4146042..4146440 - 399 WP_071509808.1 VOC family protein -
K3U93_RS18960 (K3U93_18960) 4146579..4146842 - 264 WP_083012388.1 type II toxin-antitoxin system RelE/ParE family toxin -
K3U93_RS18965 (K3U93_18965) 4146839..4147117 - 279 WP_083012385.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
K3U93_RS18970 (K3U93_18970) 4147220..4147657 - 438 WP_083012383.1 type II toxin-antitoxin system VapC family toxin Toxin
K3U93_RS18975 (K3U93_18975) 4147654..4147893 - 240 WP_071509811.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
K3U93_RS18980 (K3U93_18980) 4147967..4149064 - 1098 WP_083012380.1 redox-regulated ATPase YchF -
K3U93_RS18985 (K3U93_18985) 4149178..4150299 + 1122 WP_176220073.1 hypothetical protein -
K3U93_RS18990 (K3U93_18990) 4150307..4151317 - 1011 WP_083012435.1 4-hydroxy-3-methylbut-2-enyl diphosphate reductase -
K3U93_RS18995 (K3U93_18995) 4151403..4151987 + 585 WP_083012378.1 lipid droplet-associated protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4143453..4153526 10073


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(8-125)

Antitoxin

SpoVT-AbrB domain

(4-33)


Sequences

Toxin        


Download         Length: 146 a.a.        Molecular weight: 14926.76 Da        Isoelectric Point: 6.4901

>T212424 WP_083012383.1 NZ_CP080999:c4147657-4147220 [Mycobacterium malmoense]
VTGRRLSVDTSVAVPLLVASHERHHAVAEWARGRSLSLSSHALAETYSVLTRLPGDARVAPADAVTLIDENFDEVLVLSA
TAARGAHRELAANGVAGGATYDGLVALAGREHGAVLVSRDARARSTYETLGVAVEVLVGAAGPAQ

Download         Length: 438 bp

>T212424 NZ_CP107014:2591547-2592869 [Klebsiella pneumoniae]
ATGGCGACGCTTACCACCTGGATGAACAATGTGCGCGTGGGAACCTTAACCCGCCAGGCTAACGGGGCGCACAGTTTTCG
CTATGACGAAGAGTGGCTGCGCAGCCCGCGCGCCAGACCGCTCTCCCTCTCACTGCCGCTGCAGTATGGCAATATCACTG
CCGACGCGGTGTATCACTATTTTGATAACCTGCTGCCCGACAGCCCGCAGGTCCGCGACCGGATCGTCAGGCGCTATCAG
GCGCGCTCGAAGCAGCCGTTCGATCTGCTGGCCGAAGTCGGGCGGGATAGCGTAGGGGCGGTGACCCTCCTGCCGCCGGG
GGAAGAGGCGCACCTGGAAGGATTACGCTGGCAGACGCTGGACGAGGCGCAGCTCACCGCTTTGCTGACCGCTTACCAGT
CGGATATCCCCCTCGGGATGATTACCAGCCAGGACGATTTCCGTATCTCGGTGGCCGGCGCCCAGGAGAAAACGGCGCTG
CTGCGGATGGGCGAGCAGTGGTGTATTCCGCAGGGCGCCACGCCGACCACGCATATCATTAAGCTGCCCATCGGCGAGAT
CAAGCAGCCCAATGCGACGCTGGATCTGCGTGAAAGCGTGGATAATGAGTATCTGTGCCTGGCGCTGGCCAGAGAACTGG
GCCTGGCGGTGCCGGAAGCGGAGATCATCACCACCCCGCGGATCCGCGCCCTGGCGGTAACCCGCTTCGACCGGCGCTGG
GCGCAGGAGGGACGGGTGCTGCTGCGTCTGCCGCAGGAGGATCTGTGTCAGGCTTTTGGTCTTCCTTCAGCGATGAAATA
TGAGTCTGACGGCGGGCCGGGTATCGCCGCGATCATGACCTTTCTGCTGGGCTCGAGTGAAGCGCTGAAAGATCGCTATG
ACTTTATGAAGTTCATGGTCTTCCAGTGGCTGACGGGGGCGACGGACGGTCACGCAAAAAACTTCTCAATTTACCTGTTG
CCCGGCGGCAGCTACCGCTTAACACCGTTCTACGACATTATTTCGGCGTTTCCGGTGCTGGGCGGCACGGGACTGCATCT
GCGCGATCTGAAGCTGTCGATGGGGCTCAATGCCACAAAAGGGCGTAAAACAGAGATTAACGCCATCTATCCGCGTCATT
TTCTGGCGACGGCCAAAGCGGTGAACTTTCCCCTGGAGCAGATGCTGGCGATCCTCCAGGAGTTTGCCGGGCATGTGCCG
CAGGCAATCGAAAGCGCTCGCCGGACGCTGCCGGCGGACTTTTCCAGCCACGTCTGGCAGGCCATTACAGAGAACATGCT
GAAGCTGCACGCCCGCCTGCAGCAAGGGCTGCAGGCGCTATAG

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8395.53 Da        Isoelectric Point: 5.7808

>AT212424 WP_071509811.1 NZ_CP080999:c4147893-4147654 [Mycobacterium malmoense]
MEAVIDSGGRVVLPKHLRDALGLTPGTTVDISPYGTGVQVTPGGRTARLEREADGRLVSRGDAAVTDEMMYALIDSVRR

Download         Length: 240 bp

>AT212424 NZ_CP107014:2591281-2591547 [Klebsiella pneumoniae]
ATGAATTCCCCGCAGATATACAGTCCCGTGCAGCTGGCCAATTACCTGAAGCTGCTGCGCCAGCAGAACCACTGGACCCA
GGATGCGCTGGCCAGGCGGATCGGCATTAAGCAGGCCACGCTGTCCAATTTTGAAAATCACCCCGACAAAACCACCTTAA
CCACGCTGTTTAAGATCCTCCAGTCGCTGGGGGTGGTGATGACGCTGAACGCCAAAGCTGCTGAGACGGCGCCGGCTCCC
GATAACAACACGGACCTTGACTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References