Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapC-relB/Phd(antitoxin) |
| Location | 4146839..4147657 | Replicon | chromosome |
| Accession | NZ_CP080999 | ||
| Organism | Mycobacterium malmoense strain ATCC 29571 | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | - |
| Locus tag | K3U93_RS18970 | Protein ID | WP_083012383.1 |
| Coordinates | 4147220..4147657 (-) | Length | 146 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | - |
| Locus tag | K3U93_RS18965 | Protein ID | WP_083012385.1 |
| Coordinates | 4146839..4147117 (-) | Length | 93 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| K3U93_RS18935 (K3U93_18935) | 4142123..4142635 | - | 513 | WP_083012395.1 | OsmC family protein | - |
| K3U93_RS18940 (K3U93_18940) | 4143016..4143360 | - | 345 | Protein_3777 | hypothetical protein | - |
| K3U93_RS18945 (K3U93_18945) | 4143453..4143800 | + | 348 | WP_139797194.1 | hypothetical protein | - |
| K3U93_RS18950 (K3U93_18950) | 4143775..4144953 | - | 1179 | WP_139797193.1 | hypothetical protein | - |
| K3U93_RS25040 | 4145465..4145854 | - | 390 | WP_230981427.1 | hypothetical protein | - |
| K3U93_RS18955 (K3U93_18955) | 4146042..4146440 | - | 399 | WP_071509808.1 | VOC family protein | - |
| K3U93_RS18960 (K3U93_18960) | 4146579..4146842 | - | 264 | WP_083012388.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| K3U93_RS18965 (K3U93_18965) | 4146839..4147117 | - | 279 | WP_083012385.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| K3U93_RS18970 (K3U93_18970) | 4147220..4147657 | - | 438 | WP_083012383.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
| K3U93_RS18975 (K3U93_18975) | 4147654..4147893 | - | 240 | WP_071509811.1 | AbrB/MazE/SpoVT family DNA-binding domain-containing protein | - |
| K3U93_RS18980 (K3U93_18980) | 4147967..4149064 | - | 1098 | WP_083012380.1 | redox-regulated ATPase YchF | - |
| K3U93_RS18985 (K3U93_18985) | 4149178..4150299 | + | 1122 | WP_176220073.1 | hypothetical protein | - |
| K3U93_RS18990 (K3U93_18990) | 4150307..4151317 | - | 1011 | WP_083012435.1 | 4-hydroxy-3-methylbut-2-enyl diphosphate reductase | - |
| K3U93_RS18995 (K3U93_18995) | 4151403..4151987 | + | 585 | WP_083012378.1 | lipid droplet-associated protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 4143453..4153526 | 10073 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 146 a.a. Molecular weight: 14926.76 Da Isoelectric Point: 6.4901
>T212423 WP_083012383.1 NZ_CP080999:c4147657-4147220 [Mycobacterium malmoense]
VTGRRLSVDTSVAVPLLVASHERHHAVAEWARGRSLSLSSHALAETYSVLTRLPGDARVAPADAVTLIDENFDEVLVLSA
TAARGAHRELAANGVAGGATYDGLVALAGREHGAVLVSRDARARSTYETLGVAVEVLVGAAGPAQ
VTGRRLSVDTSVAVPLLVASHERHHAVAEWARGRSLSLSSHALAETYSVLTRLPGDARVAPADAVTLIDENFDEVLVLSA
TAARGAHRELAANGVAGGATYDGLVALAGREHGAVLVSRDARARSTYETLGVAVEVLVGAAGPAQ
Download Length: 438 bp
>T212423 NZ_CP107014:867446-867853 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCGTGC
GCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCCGAA
TGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGGACA
GCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGGCGC
AGGAGTAA
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCGTGC
GCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCCGAA
TGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGGACA
GCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGGCGC
AGGAGTAA
Antitoxin
Download Length: 93 a.a. Molecular weight: 10243.59 Da Isoelectric Point: 4.5593
>AT212423 WP_083012385.1 NZ_CP080999:c4147117-4146839 [Mycobacterium malmoense]
MSTLPLAEVRANLSKLVDEAVRTHERIEVTRQGRRAAVILSADDFDSIMETLAILSDQELMREVRAAEAESGQTYTLDEV
TAEMRAAGRLPR
MSTLPLAEVRANLSKLVDEAVRTHERIEVTRQGRRAAVILSADDFDSIMETLAILSDQELMREVRAAEAESGQTYTLDEV
TAEMRAAGRLPR
Download Length: 279 bp
>AT212423 NZ_CP107014:867199-867465 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|