Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 3720174..3720814 Replicon chromosome
Accession NZ_CP080999
Organism Mycobacterium malmoense strain ATCC 29571

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag K3U93_RS17065 Protein ID WP_083010951.1
Coordinates 3720174..3720593 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag K3U93_RS17070 Protein ID WP_083010950.1
Coordinates 3720590..3720814 (-) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K3U93_RS17045 (K3U93_17045) 3715237..3716433 - 1197 WP_083010954.1 hypothetical protein -
K3U93_RS25275 3717582..3717707 + 126 WP_254893611.1 hypothetical protein -
K3U93_RS17050 (K3U93_17050) 3718065..3718457 + 393 WP_083010953.1 hypothetical protein -
K3U93_RS17055 (K3U93_17055) 3718458..3719207 + 750 WP_139797017.1 RES domain-containing protein -
K3U93_RS17060 (K3U93_17060) 3719343..3719939 - 597 WP_071510131.1 winged helix-turn-helix domain-containing protein -
K3U93_RS17065 (K3U93_17065) 3720174..3720593 - 420 WP_083010951.1 type II toxin-antitoxin system VapC family toxin Toxin
K3U93_RS17070 (K3U93_17070) 3720590..3720814 - 225 WP_083010950.1 antitoxin Antitoxin
K3U93_RS17075 (K3U93_17075) 3721344..3722531 - 1188 WP_083010949.1 hypothetical protein -
K3U93_RS17080 (K3U93_17080) 3723003..3723287 - 285 WP_083010948.1 DUF1876 family protein -
K3U93_RS17085 (K3U93_17085) 3723426..3724253 - 828 WP_083010947.1 SDR family NAD(P)-dependent oxidoreductase -
K3U93_RS17090 (K3U93_17090) 3724363..3725583 - 1221 WP_083010997.1 cytochrome P450 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-128)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 14855.89 Da        Isoelectric Point: 7.1290

>T212421 WP_083010951.1 NZ_CP080999:c3720593-3720174 [Mycobacterium malmoense]
VTALLDVNVLIALSWRNHAHHSAARQWFTRSSSNGWATTPITEVGFVRISSDRRVMHVSTTPATALAQLEALRALPGHAF
WPDDVPLVVGEGGDRGAVSSHRLVTDCHLIALVARYGGRLVTFDAALADSAPAGLVEVL

Download         Length: 420 bp

>T212421 NZ_CP107014:345666-346013 [Klebsiella pneumoniae]
ATGTGGGATGTAGAAACGACGGATACGTTTGATGCCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCCTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTGCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTGTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGTGGGCAATAAGGATGGCATGAATGAGAAACGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 7986.02 Da        Isoelectric Point: 3.9937

>AT212421 WP_083010950.1 NZ_CP080999:c3720814-3720590 [Mycobacterium malmoense]
MRTTLQIDDDILEDARSIARSEGRSVGAVISDLARRSLRPVGIVVVDGLPMFDVPPDAPIIADEDVARGLEEDV

Download         Length: 225 bp

>AT212421 NZ_CP107014:346013-346312 [Klebsiella pneumoniae]
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGATAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGGCTGATAACGACCCTCGGCTTTCGACCCTAAAACGCTACATTGCGGCATTGGGG
GGAGAACTCAGTATAAATGTCACATTGCCGACTGGAAAAAAAGTCTCGTTTAATTTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References