Detailed information of TA system TA212420

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/MazF(toxin)
• Location: 3104064..3104661
• Replicon: chromosome
• Accession: NZ_CP080999
• Organism: Mycobacterium malmoense strain ATCC 29571

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: K3U93_RS14400
• Protein ID: WP_083012607.1
• Coordinates: 3104064..3104432 (-)
• Length: 123 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: -
• Locus tag: K3U93_RS14405
• Protein ID: WP_071509019.1
• Coordinates: 3104425..3104661 (-)
• Length: 79 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3099683..3122679	22996

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (5-110)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 123 a.a.
• Molecular weight: 12736.68 Da
• Isoelectric Point: 6.0706

>T212420 WP_083012607.1 NZ_CP080999:c3104432-3104064 [Mycobacterium malmoense]
MPEPRRGELWLVALGAARAGGPGKHHPAVVVSVDEILTGLDDELVVVVPVSSSRSGSPLRPPVMPAEGVDTQSVAVCRDI
RAVARSRLVERLGTVAPDTMHGIEHALGLILGVDTGLSPPSW

Nucleotide

• Length: 369 bp

>T212420 NZ_CP107014:319695-320063 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCAGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACTCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCGGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCGGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGCTTGCGCGGATGA

Antitoxin

Protein

• Length: 79 a.a.
• Molecular weight: 8404.25 Da
• Isoelectric Point: 4.5742

>AT212420 WP_071509019.1 NZ_CP080999:c3104661-3104425 [Mycobacterium malmoense]
MSTSTTTIRVSVRTRDRLVAQARQRGISLAGLVTELASRAEQEAVFRAERDATLADAGIAGVREEDRDWDDTAGDGIA

Nucleotide

• Length: 237 bp

>AT212420 NZ_CP107014:319477-319698 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGACGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA