Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2881059..2881744 Replicon chromosome
Accession NZ_CP080999
Organism Mycobacterium malmoense strain ATCC 29571

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag K3U93_RS13415 Protein ID WP_083011068.1
Coordinates 2881059..2881490 (-) Length 144 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag K3U93_RS13420 Protein ID WP_083011067.1
Coordinates 2881487..2881744 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K3U93_RS13385 (K3U93_13385) 2876764..2877237 - 474 WP_230981213.1 type II toxin-antitoxin system VapC family toxin -
K3U93_RS13390 (K3U93_13390) 2877176..2877409 - 234 WP_230981214.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
K3U93_RS13395 (K3U93_13395) 2877925..2878839 + 915 WP_230981217.1 SAM-dependent methyltransferase -
K3U93_RS13400 (K3U93_13400) 2878909..2879559 - 651 WP_071510324.1 TetR/AcrR family transcriptional regulator -
K3U93_RS13405 (K3U93_13405) 2880085..2880525 + 441 WP_139797034.1 hypothetical protein -
K3U93_RS13410 (K3U93_13410) 2880532..2880882 + 351 WP_071512222.1 DUF5615 family PIN-like protein -
K3U93_RS13415 (K3U93_13415) 2881059..2881490 - 432 WP_083011068.1 type II toxin-antitoxin system VapC family toxin Toxin
K3U93_RS13420 (K3U93_13420) 2881487..2881744 - 258 WP_083011067.1 CopG family transcriptional regulator Antitoxin
K3U93_RS13425 (K3U93_13425) 2882084..2882869 - 786 WP_071512225.1 alpha/beta hydrolase -
K3U93_RS13430 (K3U93_13430) 2883136..2884617 + 1482 WP_139797033.1 biotin carboxylase -
K3U93_RS13435 (K3U93_13435) 2884661..2885857 + 1197 WP_083011066.1 serine hydrolase -
K3U93_RS13440 (K3U93_13440) 2886367..2886627 + 261 Protein_2686 antitoxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2850011..2882869 32858


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-133)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-36)


Sequences

Toxin        


Download         Length: 144 a.a.        Molecular weight: 15770.86 Da        Isoelectric Point: 4.5713

>T212419 WP_083011068.1 NZ_CP080999:c2881490-2881059 [Mycobacterium malmoense]
MRLLDLNILIYAIDESSSRHVVAKDWLDDTLSGSDTVAFSWHVLIGFVRLSTRAAVFERPLTVDESFDVVDGWLEQPCVT
VVHPTDRHAIVLRGILTPLGTAGNLTSDAHLAALSIEHGAELCSTDVDFSRFSGVRWIDPLQT

Download         Length: 432 bp

>T212419 NZ_CP107011:52897-53049 [Salmonella enterica subsp. enterica serovar Paratyphi B]
ATGCCACAGCGAACGTTTTTAATGATGTTAATCGTCATCTGTGTGACGATTCTGTGTTTTGTCTGGATGGTGAGGGATTC
GCTTTGCGGACTCCGGCTCCAGCAGGGAAACACAGTGCTTGTGGCAACGTTAGCCTACGAAGTTAAACGTTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9348.72 Da        Isoelectric Point: 11.0899

>AT212419 WP_083011067.1 NZ_CP080999:c2881744-2881487 [Mycobacterium malmoense]
MRTTVTLDPDVVAALQRAARERGASFKAVLNDAVRRGLSGGPTQRRYHTPSRDMGLRTGFDIDKALTLVAADEDAEILRK
LALRK

Download         Length: 258 bp

>AT212419 NZ_CP107011:c52842-52785 [Salmonella enterica subsp. enterica serovar Paratyphi B]
GCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References