Detailed information of TA system TA212418

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/PemK-MazE
• Location: 2870656..2871191
• Replicon: chromosome
• Accession: NZ_CP080999
• Organism: Mycobacterium malmoense strain ATCC 29571

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: K3U93_RS13370
• Protein ID: WP_071510758.1
• Coordinates: 2870859..2871191 (+)
• Length: 111 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: -
• Locus tag: K3U93_RS13365
• Protein ID: WP_071510757.1
• Coordinates: 2870656..2870862 (+)
• Length: 69 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K3U93_RS13320 (K3U93_13320)	2865704..2865910	+	207	WP_071510751.1	DUF2191 domain-containing protein	-
K3U93_RS13325 (K3U93_13325)	2865901..2866323	+	423	WP_083011075.1	PIN domain-containing protein	-
K3U93_RS13330 (K3U93_13330)	2866448..2867278	-	831	WP_071510753.1	DUF1906 domain-containing protein	-
K3U93_RS13335 (K3U93_13335)	2867755..2867991	+	237	WP_083011074.1	type II toxin-antitoxin system prevent-host-death family antitoxin	-
K3U93_RS13340 (K3U93_13340)	2868012..2868425	+	414	WP_071510773.1	type II toxin-antitoxin system VapC family toxin	-
K3U93_RS13345 (K3U93_13345)	2868707..2868940	+	234	WP_071510754.1	hypothetical protein	-
K3U93_RS13350 (K3U93_13350)	2868930..2869241	+	312	WP_071510755.1	type II toxin-antitoxin system PemK/MazF family toxin	-
K3U93_RS13355 (K3U93_13355)	2869554..2870012	+	459	WP_083011073.1	prevent-host-death protein	-
K3U93_RS13360 (K3U93_13360)	2870024..2870386	+	363	WP_083011072.1	hypothetical protein	-
K3U93_RS13365 (K3U93_13365)	2870656..2870862	+	207	WP_071510757.1	DUF3018 family protein	Antitoxin
K3U93_RS13370 (K3U93_13370)	2870859..2871191	+	333	WP_071510758.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
K3U93_RS13375 (K3U93_13375)	2871434..2873035	-	1602	WP_071510805.1	integrase	-
K3U93_RS13380 (K3U93_13380)	2873351..2876092	-	2742	WP_139797035.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	2850011..2882869	32858

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (2-108)

Antitoxin

• Antitoxin MazE-like (4-66)

Sequences

Toxin

Protein

• Length: 111 a.a.
• Molecular weight: 11803.62 Da
• Isoelectric Point: 7.2039

>T212418 WP_071510758.1 NZ_CP080999:2870859-2871191 [Mycobacterium malmoense]
VNRGEIWTVAGGVYAAKPRPAVIVQDDLFDATSSVTVAPMSSTLLDAPLMRIRIAGGDGRLSGLDHDSDVMIDKLTTVKR
SNVHARVGRLTAEQVVEVERAMMAFLGLAR

Nucleotide

• Length: 333 bp

>T212418 NZ_CP107011:7337-7615 [Salmonella enterica subsp. enterica serovar Paratyphi B]
ATGGAGATATTCTGGACCATGCTGGCCAGCCAGGACAGGAAGCGCATTCGTAAGTACATTGCGGAGCAGAACCTGATGGC
CGCCATTGAACTGGACGAACGGATTGGTTATTCAGCCAGCAGCCTGGCCGGGCAGCCGTATAAAGGCCGCAACGGTCGTG
TGGAAGGTACCCGGGAACTGGTTATTCACCCGCATTTTGTTCTGGTTTATGAGGTCGACAGCCAGTGGGGAAAAGTGTAT
ATCCTGCGCGTGTTGCATACTGCACAGAAGTGGCCATAG

Antitoxin

Protein

• Length: 69 a.a.
• Molecular weight: 7915.77 Da
• Isoelectric Point: 4.4805

>AT212418 WP_071510757.1 NZ_CP080999:2870656-2870862 [Mycobacterium malmoense]
MAVRERVGEYRRRMRERGLRPLQVWVPDVRTESFAAEAHRQASLVALADESADDQDFIEAISTPWDEE

Nucleotide

• Length: 207 bp

>AT212418 NZ_CP107011:7068-7337 [Salmonella enterica subsp. enterica serovar Paratyphi B]
ATGGCACAGGTTAATATGAGTTTAAGAATCGACGCTGAACTGAAGGATGCTTTTATGGCCGCTGCAAAAAGCATGGACCG
TAATGGCTCTCAGTTAATTCGGGATTTTATGCGCCAGACCGTTGAACGGCAGCATAATACCTGGTTCCGTGACCAGGTTG
AGGCAGGACGTCAGCAACTCGAGCGCGGCGATGTGCTTCCCCATGACATGGTCGAATCTTCCGCTGCTGCATGGCGGGAT
GAAATGAGCAGGAAGGTTGCCGGTAAATGA