Detailed information of TA system TA212417

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YoeB-YefM
• Location: 2264132..2264661
• Replicon: chromosome
• Accession: NZ_CP080999
• Organism: Mycobacterium malmoense strain ATCC 29571

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: K3U93_RS10645
• Protein ID: WP_071510051.1
• Coordinates: 2264132..2264389 (-)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: K3U93_RS10650
• Protein ID: WP_083011676.1
• Coordinates: 2264386..2264661 (-)
• Length: 92 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K3U93_RS10615 (K3U93_10615)	2259809..2260531	+	723	WP_083011669.1	hypothetical protein	-
K3U93_RS10620 (K3U93_10620)	2260612..2260764	+	153	Protein_2119	type II toxin-antitoxin system VapB family antitoxin	-
K3U93_RS10625 (K3U93_10625)	2260862..2261246	+	385	Protein_2120	VapC toxin family PIN domain ribonuclease	-
K3U93_RS10630 (K3U93_10630)	2261360..2261608	-	249	WP_083011671.1	hypothetical protein	-
K3U93_RS10635 (K3U93_10635)	2262143..2263309	+	1167	WP_139797141.1	hypothetical protein	-
K3U93_RS10640 (K3U93_10640)	2263429..2264082	+	654	WP_083011727.1	DUF5642 family protein	-
K3U93_RS10645 (K3U93_10645)	2264132..2264389	-	258	WP_071510051.1	Txe/YoeB family addiction module toxin	Toxin
K3U93_RS10650 (K3U93_10650)	2264386..2264661	-	276	WP_083011676.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
K3U93_RS24845	2264919..2265563	-	645	WP_139797142.1	hypothetical protein	-
K3U93_RS10660 (K3U93_10660)	2265705..2266262	-	558	WP_071510053.1	hypothetical protein	-
K3U93_RS10665 (K3U93_10665)	2267352..2267864	+	513	WP_071510054.1	MarR family transcriptional regulator	-
K3U93_RS10670 (K3U93_10670)	2268065..2268724	+	660	WP_071510055.1	DUF5642 family protein	-
K3U93_RS10675 (K3U93_10675)	2268738..2269229	-	492	WP_071510056.1	MarR family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	2241271..2289745	48474

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (6-85)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (2-72)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 10129.45 Da
• Isoelectric Point: 10.1305

>T212417 WP_071510051.1 NZ_CP080999:c2264389-2264132 [Mycobacterium malmoense]
VRSIHFDPNAWEDFLFWLGSDRKAARRVTRLIAEVQRDPFRGTGKPEPLKGELSGYWSRRIDDQHRLVYRADGDEVKILK
ARYHY

Nucleotide

• Length: 258 bp

>T212417 NZ_CP107010:4498384-4498695 [Salmonella enterica subsp. enterica serovar Paratyphi B]
GTGCATGTTATCAGCCGAAAACCGTTCAATGAAGCGATGCTCATGTATCCAAACCATGAGCTTGCTCTCACTGAGTTGCT
GAATGTTCTGGAGAAAAAAACATTCACTCAGCCTGAAGAGATGAAGCGGTATATTCCTTCACTGGATAATTTTAAGCACA
GAGATAAATGGTGGGTGATTGATGTTTCTGGTAACAGCCTGAGACTCATTTCCTACATAGATTTCAGGTTACATAAGATA
TTTGTGAAACATATCGTTTCCCATGCCGAATATGACAAACTGACCGCATACTATCGGGGTAATAAAGAATGA

Antitoxin

Protein

• Length: 92 a.a.
• Molecular weight: 10108.34 Da
• Isoelectric Point: 5.0622

>AT212417 WP_083011676.1 NZ_CP080999:c2264661-2264386 [Mycobacterium malmoense]
MSISASEARQRLYPLLAQVNTDHQPVRITSKAGDAVLMSADDYDSWQETVYLLRSPKNAQRLMEAVARDKAGHFALTKSV
DELQEMAGGQE

Nucleotide

• Length: 276 bp

>AT212417 NZ_CP107010:4498692-4499138 [Salmonella enterica subsp. enterica serovar Paratyphi B]
ATGAGAACTCATCGTCAGATGGATGCAACCAGCGCAAAAAAGATCGTTGATACCTTCAGCGATGCGGTAAAAAGCGTCCC
ACTGATGGGGGAAGACCGAAATGACAATGAGTATCGCAGGGCACTAGCGCTAGTGGAGTTTCTGGTCGACCACGACGATC
TTGAAAACCCACTATTTGAATTGCTCTGTGCCCGAATCAGTGAATACGAAAAACATGCGCCGGAATTCAAAGCACTCAAC
CAACACCTGGAGAAAACGCCCCCTGGCGTTTCAGTATTGCGAACGCTCATGGATCAATACGGTCTCAAAGCAGCAGATCT
TGCCAACGAACTTGGTTCTAAATCGAACGTCAGCAACATCTTAAATGGCCGCAGAGCACTAACGGTTAATCATATTAAAG
CGCTTACACAACGCTTCAAACTACCAGCAGATGCCTTCATCGAGTAG