Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 2245550..2246178 Replicon chromosome
Accession NZ_CP080999
Organism Mycobacterium malmoense strain ATCC 29571

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag K3U93_RS10550 Protein ID WP_083011642.1
Coordinates 2245765..2246178 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag K3U93_RS10545 Protein ID WP_071510089.1
Coordinates 2245550..2245774 (+) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K3U93_RS10520 (K3U93_10520) 2240787..2241158 - 372 WP_083010903.1 hypothetical protein -
K3U93_RS10525 (K3U93_10525) 2241271..2241921 - 651 WP_139797002.1 hypothetical protein -
K3U93_RS10530 (K3U93_10530) 2242327..2242887 - 561 WP_071513463.1 MarR family transcriptional regulator -
K3U93_RS10535 (K3U93_10535) 2243781..2244080 + 300 WP_220688608.1 PE family protein -
K3U93_RS10540 (K3U93_10540) 2244123..2245316 + 1194 WP_220688609.1 PPE family protein -
K3U93_RS10545 (K3U93_10545) 2245550..2245774 + 225 WP_071510089.1 hypothetical protein Antitoxin
K3U93_RS10550 (K3U93_10550) 2245765..2246178 + 414 WP_083011642.1 PIN domain nuclease Toxin
K3U93_RS25370 (K3U93_10555) 2247040..2248224 + 1185 WP_176220041.1 PPE family protein -
K3U93_RS10560 (K3U93_10560) 2248306..2249106 + 801 WP_230981670.1 sulfotransferase -
K3U93_RS10565 (K3U93_10565) 2249595..2249927 + 333 WP_139797137.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2241271..2289745 48474


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(24-126)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 14950.17 Da        Isoelectric Point: 8.5681

>T212416 WP_083011642.1 NZ_CP080999:2245765-2246178 [Mycobacterium malmoense]
VAVTRWLIDKSAYARLQLGQASNVDQWNARIGRGLVHLSTITRLELGYSARNGHAGRRQFASPPLSLMPVEYLTPAIEDR
ALEVQMLLADRGQHRAPSIPDLLVAATAEKAGLRVLVADKDFDLIANITGQPIDALT

Download         Length: 414 bp

>T212416 NZ_CP107010:c4496922-4496548 [Salmonella enterica subsp. enterica serovar Paratyphi B]
ATGGTCAAAGGGTCTGCGCTTTTTGATACCAATATCCTCATCGACCTGTTTAGCGGTCGAATTGAAGCGAAACATGCGCT
GGAAGCGTATCCGCCACAGAATGCGATTAGCCTTATCACATGGATGGAAGTGATGGTGGGTGCTAAGAAATATCATCAGG
AAAACCGCACGCGCATTGCATTAAGTGCGTTCAATATTATTGGCGTAACACAGGAAATCGCGGAGCGAAGCGTCATTGTC
AGGCAGGAGTATGGCATGAAACTCCCGGATGCGATCATTCTGGCCACTGCACAAGTCCATCGTTGTGAGCTTGTGACGCG
TAATACAAAAGACTTTGCCGATATTCCGGGAGTGATCACGCCGTATCACTTGTAG

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8176.19 Da        Isoelectric Point: 4.3867

>AT212416 WP_071510089.1 NZ_CP080999:2245550-2245774 [Mycobacterium malmoense]
MPDVLIRGLSEEAVENIDAAAAALGLSRNEYLRRTFERAAVQPVKKTVTAEDWQRSAETFADLADPDVMAAAWR

Download         Length: 225 bp

>AT212416 NZ_CP107010:c4497164-4496922 [Salmonella enterica subsp. enterica serovar Paratyphi B]
ATGATGGCTGGGATGGATATGGGCAGAATTTTACTCGATTTATCAGACGATGTGATTAAACGGCTTGACGATCTCAAGGT
GCAACGCAACCTGCCTCGTGCAGAACTCTTGCGGGAGGCCGTTGAGCAGTATCTGGAAAGACAGGATCGGGCTGAGACCA
CAATTTCGAAAGCATTGGGGCTCTGGCAAGGCTGTGAGGAAGATGGCGTTGAATACCAACGTAAACTTCGTGAGGAATGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References