212415

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PhRel-ATphRel/-
Location 2151682..2152744 Replicon chromosome
Accession NZ_CP080999
Organism Mycobacterium malmoense strain ATCC 29571

Toxin (Protein)


Gene name phRel Uniprot ID -
Locus tag K3U93_RS10135 Protein ID WP_071510778.1
Coordinates 2151914..2152744 (-) Length 277 a.a.

Antitoxin (Protein)


Gene name ATphRel Uniprot ID -
Locus tag K3U93_RS10130 Protein ID WP_230981627.1
Coordinates 2151682..2151912 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K3U93_RS10110 (K3U93_10110) 2147722..2148060 - 339 WP_054585837.1 hypothetical protein -
K3U93_RS10115 (K3U93_10115) 2148349..2148690 + 342 WP_230981626.1 antibiotic biosynthesis monooxygenase -
K3U93_RS10120 (K3U93_10120) 2148677..2149894 + 1218 WP_071510779.1 helix-turn-helix domain-containing protein -
K3U93_RS10125 (K3U93_10125) 2150507..2151190 - 684 WP_071510775.1 class I SAM-dependent methyltransferase -
K3U93_RS10130 (K3U93_10130) 2151682..2151912 - 231 WP_230981627.1 hypothetical protein Antitoxin
K3U93_RS10135 (K3U93_10135) 2151914..2152744 - 831 WP_071510778.1 hypothetical protein Toxin
K3U93_RS10140 (K3U93_10140) 2152902..2153279 + 378 Protein_2023 hypothetical protein -
K3U93_RS10145 (K3U93_10145) 2153299..2155242 + 1944 WP_083010857.1 excinuclease ABC subunit UvrC -
K3U93_RS10150 (K3U93_10150) 2155239..2156126 + 888 WP_071513530.1 RNase adapter RapZ -
K3U93_RS10155 (K3U93_10155) 2156123..2157155 + 1033 Protein_2026 uridine diphosphate-N-acetylglucosamine-binding protein YvcK -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RelA/SpoT

(67-177)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 277 a.a.        Molecular weight: 30202.93 Da        Isoelectric Point: 4.6221

>T212415 WP_071510778.1 NZ_CP080999:c2152744-2151914 [Mycobacterium malmoense]
VDLESRPPWSNNALRRLGAALRDGVDPPIDCPSYADVMLWHFDLAAEVQDQIESGSWSIRSELLATKAGRLTPDLQVSSR
PKTQDTLVEKLQRQPSLQLNAVQDLAGVRIDADLLLGEQMSLAREIASYFCADESAIHDLRDGTHAGYRGVHVWLRLPAG
RVEIQIRTILQSLWANLFEKLADEVGRGIRYGEPVEPSPGVDVGRIQRAVQSMQEFSAKVAASEADWQQCSEIEDPGRRG
VALGTAAMDRAMWVGLVAYAAQKASGEAESSKGEDG

Download         Length: 831 bp

>T212415 NZ_CP107010:c4058992-4058708 [Salmonella enterica subsp. enterica serovar Paratyphi B]
ATGACTTATGAACTGGAATTCGACCCGAGGGCCTTAAAAGAGTGGCATAAGCTGGGCGATACGGTAAAGGCTCAGCTTAA
GAAAAAGTTGGCTGATGTGCTATTGAACCCCAGAATCGACTCTGCCCGTTTAAACGGTCTTCCTGACTGCTATAAAATTA
AGCTTAAATCGTCCGGTTATCGTCTGGTGTACCAGGTTCGGGATGACGTTGTGATTGTGTTTGTTGTCGCGGTCGGTAAG
CGAGAACATTCAGCCGTCTATCACGATGCAAACAAACGGCTTTAG

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8845.01 Da        Isoelectric Point: 6.4636

>AT212415 WP_230981627.1 NZ_CP080999:c2151912-2151682 [Mycobacterium malmoense]
MAGYVVEYNRRTHERRITEFVTTREAMEYRLKLEAERTDKNVEIAALVSKSLDTLKQTHSRYFSGAELAAEDCMLT

Download         Length: 231 bp

>AT212415 NZ_CP107010:c4059224-4058982 [Salmonella enterica subsp. enterica serovar Paratyphi B]
ATGGCCACGCTGAACGTCCGTCTGGATGACAAACTCAAAAATGAGGCTTATGCCGTGCTGGAAAAACTGAACATTACTCC
AACGGAAGCCGTGCGATTACTGTTCCAGTACGTCGCGGAAACGGGGCGCATGCCAGTGAAAACCGTCACTCTTAGCGACA
GTGAAGATGCATTGATTCAGACAGTTCGGGAGAGGCTGTCTAGTCCGCAAAAGGGAATCAAGGTTAGTCTGGATGACTTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References