Detailed information of TA system TA212414

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN-PHD
• Location: 2066984..2067618
• Replicon: chromosome
• Accession: NZ_CP080999
• Organism: Mycobacterium malmoense strain ATCC 29571

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: K3U93_RS09745
• Protein ID: WP_083013017.1
• Coordinates: 2066984..2067376 (-)
• Length: 131 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: K3U93_RS09750
• Protein ID: WP_071508812.1
• Coordinates: 2067373..2067618 (-)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K3U93_RS09725 (K3U93_09725)	2063134..2064330	+	1197	WP_071509599.1	hypothetical protein	-
K3U93_RS09730 (K3U93_09730)	2065005..2066270	+	1266	WP_230981624.1	group II intron reverse transcriptase/maturase	-
K3U93_RS09735 (K3U93_09735)	2066411..2066638	+	228	WP_083013021.1	ribbon-helix-helix domain-containing protein	-
K3U93_RS09740 (K3U93_09740)	2066635..2066937	+	303	WP_083013019.1	toxin	-
K3U93_RS09745 (K3U93_09745)	2066984..2067376	-	393	WP_083013017.1	type II toxin-antitoxin system VapC family toxin	Toxin
K3U93_RS09750 (K3U93_09750)	2067373..2067618	-	246	WP_071508812.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
K3U93_RS09755 (K3U93_09755)	2067759..2070419	-	2661	WP_083013015.1	circularly permuted type 2 ATP-grasp protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• VapC-like Sll0205 protein, PIN domain (5-128)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (9-48)

Sequences

Toxin

Protein

• Length: 131 a.a.
• Molecular weight: 14704.78 Da
• Isoelectric Point: 5.9799

>T212414 WP_083013017.1 NZ_CP080999:c2067376-2066984 [Mycobacterium malmoense]
VKRYLVDTHVWLWMQSDPDRLRDEAREIVQDARNSVLLSAASAWEIAIKYRLGKLPLPEAPASYLPDRMRRSGTSPLPVD
HAHALRTAELPDHHRDPFDRLLIAQAQLLDLTIMTADEQLSAYDVAVVAA

Nucleotide

• Length: 393 bp

>T212414 NZ_CP107010:c4017790-4017482 [Salmonella enterica subsp. enterica serovar Paratyphi B]
ATGCAATACATGGTTTATCGCAATAAAGGAAACAGCAAGGCTTATCCTTATTTACTTGATGTGCAAAGCGATATTATTGA
TGAACTGCATACTCGCATGGTTATCCCATTGTTTCCTGTGAGCAGGTTGGTAAATAACCCAGTTAAGCGCCTCACGCCCA
CTCTGAATGTGGAAGGTAATGACTATCTGGTGATGACTCACGAAATGGCGAGTATCAGGCTTTCGCAGATTGGTGATGAG
GTGATGGATGTTCGTTCCCACAGGCAAACCATCAAAAATGCTCTCGATTTTATCTTTGACGGGTTCTGA

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 9013.31 Da
• Isoelectric Point: 6.2190

>AT212414 WP_071508812.1 NZ_CP080999:c2067618-2067373 [Mycobacterium malmoense]
MTKSAAIRVGVHEAKTRMSELLRLVDSGQEIEIARGGEPVAKLVPFRSPEIRRLGIDHGVYAVPDDFDAPLPDDVLHSFY
R

Nucleotide

• Length: 246 bp

>AT212414 NZ_CP107010:c4018032-4017793 [Salmonella enterica subsp. enterica serovar Paratyphi B]
ATGTCGGGTATGAGTGTACGACATAAAAAAACAGTCAGTGTCACGCTGGAACCTGCATTGCTTCAGCAAGCCCGTGATGC
AGGTATTAATCTGTCTGCGGTGCTTACCGCCGCGCTGAAAGAGGAAATCAGTGCCACGGGCGTTGAACGCTGGAAAGCAG
AAAATAGAGCGGGTTTGCAGGAGCTCAATCGTATTACTGATGAGCACGGCCTTTTATCGGACGATTACAGGACGTTTTAA