Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapBC/PIN-PHD |
| Location | 2066984..2067618 | Replicon | chromosome |
| Accession | NZ_CP080999 | ||
| Organism | Mycobacterium malmoense strain ATCC 29571 | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | - |
| Locus tag | K3U93_RS09745 | Protein ID | WP_083013017.1 |
| Coordinates | 2066984..2067376 (-) | Length | 131 a.a. |
Antitoxin (Protein)
| Gene name | vapB | Uniprot ID | - |
| Locus tag | K3U93_RS09750 | Protein ID | WP_071508812.1 |
| Coordinates | 2067373..2067618 (-) | Length | 82 a.a. |
Genomic Context
Location: 2063134..2064330 (1197 bp)
Type: Others
Protein ID: WP_071509599.1
Type: Others
Protein ID: WP_071509599.1
Location: 2065005..2066270 (1266 bp)
Type: Others
Protein ID: WP_230981624.1
Type: Others
Protein ID: WP_230981624.1
Location: 2066411..2066638 (228 bp)
Type: Others
Protein ID: WP_083013021.1
Type: Others
Protein ID: WP_083013021.1
Location: 2066635..2066937 (303 bp)
Type: Others
Protein ID: WP_083013019.1
Type: Others
Protein ID: WP_083013019.1
Location: 2066984..2067376 (393 bp)
Type: Toxin
Protein ID: WP_083013017.1
Type: Toxin
Protein ID: WP_083013017.1
Location: 2067373..2067618 (246 bp)
Type: Antitoxin
Protein ID: WP_071508812.1
Type: Antitoxin
Protein ID: WP_071508812.1
Location: 2067759..2070419 (2661 bp)
Type: Others
Protein ID: WP_083013015.1
Type: Others
Protein ID: WP_083013015.1
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Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| K3U93_RS09725 (K3U93_09725) | 2063134..2064330 | + | 1197 | WP_071509599.1 | hypothetical protein | - |
| K3U93_RS09730 (K3U93_09730) | 2065005..2066270 | + | 1266 | WP_230981624.1 | group II intron reverse transcriptase/maturase | - |
| K3U93_RS09735 (K3U93_09735) | 2066411..2066638 | + | 228 | WP_083013021.1 | ribbon-helix-helix domain-containing protein | - |
| K3U93_RS09740 (K3U93_09740) | 2066635..2066937 | + | 303 | WP_083013019.1 | toxin | - |
| K3U93_RS09745 (K3U93_09745) | 2066984..2067376 | - | 393 | WP_083013017.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
| K3U93_RS09750 (K3U93_09750) | 2067373..2067618 | - | 246 | WP_071508812.1 | type II toxin-antitoxin system prevent-host-death family antitoxin | Antitoxin |
| K3U93_RS09755 (K3U93_09755) | 2067759..2070419 | - | 2661 | WP_083013015.1 | circularly permuted type 2 ATP-grasp protein | - |
Associated MGEs
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MGE detail | Similar MGEs | Relative position | MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| No matching records found | |||||||
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 131 a.a. Molecular weight: 14704.78 Da Isoelectric Point: 5.9799
>T212414 WP_083013017.1 NZ_CP080999:c2067376-2066984 [Mycobacterium malmoense]
VKRYLVDTHVWLWMQSDPDRLRDEAREIVQDARNSVLLSAASAWEIAIKYRLGKLPLPEAPASYLPDRMRRSGTSPLPVD
HAHALRTAELPDHHRDPFDRLLIAQAQLLDLTIMTADEQLSAYDVAVVAA
VKRYLVDTHVWLWMQSDPDRLRDEAREIVQDARNSVLLSAASAWEIAIKYRLGKLPLPEAPASYLPDRMRRSGTSPLPVD
HAHALRTAELPDHHRDPFDRLLIAQAQLLDLTIMTADEQLSAYDVAVVAA
Download Length: 393 bp
>T212414 NZ_CP107010:c4017790-4017482 [Salmonella enterica subsp. enterica serovar Paratyphi B]
ATGCAATACATGGTTTATCGCAATAAAGGAAACAGCAAGGCTTATCCTTATTTACTTGATGTGCAAAGCGATATTATTGA
TGAACTGCATACTCGCATGGTTATCCCATTGTTTCCTGTGAGCAGGTTGGTAAATAACCCAGTTAAGCGCCTCACGCCCA
CTCTGAATGTGGAAGGTAATGACTATCTGGTGATGACTCACGAAATGGCGAGTATCAGGCTTTCGCAGATTGGTGATGAG
GTGATGGATGTTCGTTCCCACAGGCAAACCATCAAAAATGCTCTCGATTTTATCTTTGACGGGTTCTGA
ATGCAATACATGGTTTATCGCAATAAAGGAAACAGCAAGGCTTATCCTTATTTACTTGATGTGCAAAGCGATATTATTGA
TGAACTGCATACTCGCATGGTTATCCCATTGTTTCCTGTGAGCAGGTTGGTAAATAACCCAGTTAAGCGCCTCACGCCCA
CTCTGAATGTGGAAGGTAATGACTATCTGGTGATGACTCACGAAATGGCGAGTATCAGGCTTTCGCAGATTGGTGATGAG
GTGATGGATGTTCGTTCCCACAGGCAAACCATCAAAAATGCTCTCGATTTTATCTTTGACGGGTTCTGA
Antitoxin
Download Length: 82 a.a. Molecular weight: 9013.31 Da Isoelectric Point: 6.2190
>AT212414 WP_071508812.1 NZ_CP080999:c2067618-2067373 [Mycobacterium malmoense]
MTKSAAIRVGVHEAKTRMSELLRLVDSGQEIEIARGGEPVAKLVPFRSPEIRRLGIDHGVYAVPDDFDAPLPDDVLHSFY
R
MTKSAAIRVGVHEAKTRMSELLRLVDSGQEIEIARGGEPVAKLVPFRSPEIRRLGIDHGVYAVPDDFDAPLPDDVLHSFY
R
Download Length: 246 bp
>AT212414 NZ_CP107010:c4018032-4017793 [Salmonella enterica subsp. enterica serovar Paratyphi B]
ATGTCGGGTATGAGTGTACGACATAAAAAAACAGTCAGTGTCACGCTGGAACCTGCATTGCTTCAGCAAGCCCGTGATGC
AGGTATTAATCTGTCTGCGGTGCTTACCGCCGCGCTGAAAGAGGAAATCAGTGCCACGGGCGTTGAACGCTGGAAAGCAG
AAAATAGAGCGGGTTTGCAGGAGCTCAATCGTATTACTGATGAGCACGGCCTTTTATCGGACGATTACAGGACGTTTTAA
ATGTCGGGTATGAGTGTACGACATAAAAAAACAGTCAGTGTCACGCTGGAACCTGCATTGCTTCAGCAAGCCCGTGATGC
AGGTATTAATCTGTCTGCGGTGCTTACCGCCGCGCTGAAAGAGGAAATCAGTGCCACGGGCGTTGAACGCTGGAAAGCAG
AAAATAGAGCGGGTTTGCAGGAGCTCAATCGTATTACTGATGAGCACGGCCTTTTATCGGACGATTACAGGACGTTTTAA