Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Rv0298-Rv0299/-
Location 2066411..2066937 Replicon chromosome
Accession NZ_CP080999
Organism Mycobacterium malmoense strain ATCC 29571

Toxin (Protein)


Gene name Rv0299 Uniprot ID -
Locus tag K3U93_RS09740 Protein ID WP_083013019.1
Coordinates 2066635..2066937 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name Rv0298 Uniprot ID -
Locus tag K3U93_RS09735 Protein ID WP_083013021.1
Coordinates 2066411..2066638 (+) Length 76 a.a.

Genomic Context

K3U93_RS09720K3U93_RS09725K3U93_RS09730K3U93_RS09735K3U93_RS09740K3U93_RS09745K3U93_RS09750K3U93_RS09755
Location: 2061825..2062880 (1056 bp)
Type: Others
Protein ID: WP_083011396.1
Location: 2063134..2064330 (1197 bp)
Type: Others
Protein ID: WP_071509599.1
Location: 2065005..2066270 (1266 bp)
Type: Others
Protein ID: WP_230981624.1
Location: 2066411..2066638 (228 bp)
Type: Antitoxin
Protein ID: WP_083013021.1
Location: 2066635..2066937 (303 bp)
Type: Toxin
Protein ID: WP_083013019.1
Location: 2066984..2067376 (393 bp)
Type: Others
Protein ID: WP_083013017.1
Location: 2067373..2067618 (246 bp)
Type: Others
Protein ID: WP_071508812.1
Location: 2067759..2070419 (2661 bp)
Type: Others
Protein ID: WP_083013015.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
K3U93_RS09720 (K3U93_09720)2061825..2062880+1056WP_083011396.1putative zinc-binding metallopeptidase-
K3U93_RS09725 (K3U93_09725)2063134..2064330+1197WP_071509599.1hypothetical protein-
K3U93_RS09730 (K3U93_09730)2065005..2066270+1266WP_230981624.1group II intron reverse transcriptase/maturase-
K3U93_RS09735 (K3U93_09735)2066411..2066638+228WP_083013021.1ribbon-helix-helix domain-containing proteinAntitoxin
K3U93_RS09740 (K3U93_09740)2066635..2066937+303WP_083013019.1toxinToxin
K3U93_RS09745 (K3U93_09745)2066984..2067376-393WP_083013017.1type II toxin-antitoxin system VapC family toxin-
K3U93_RS09750 (K3U93_09750)2067373..2067618-246WP_071508812.1type II toxin-antitoxin system prevent-host-death family antitoxin-
K3U93_RS09755 (K3U93_09755)2067759..2070419-2661WP_083013015.1circularly permuted type 2 ATP-grasp protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Ribbon-helix-helix protein, CopG

(6-41)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 10418.16 Da        Isoelectric Point: 4.6251

>T212413 WP_083013019.1 NZ_CP080999:2066635-2066937 [Mycobacterium malmoense]
VISPGDIVPRRGSDHELYVVVLSNAIHLAAATGRVVACPFIPGRVPDDAMAMVVAVRQPEGTLLPELVQWLPLSALDEPI
GAVGAAALRETTTIVTALIS

Download         Length: 303 bp

>T212413 NZ_CP107010:c3976074-3975787 [Salmonella enterica subsp. enterica serovar Paratyphi B]
ATGCCGATGGAGTTTGAATGGGATGCGAACAAGGCTAAAAGCAACCTGAGGAAGCACGGTGTCCGCTTTGAGGATGCAGT
ACTGGTGTTTGACGATCCCCGACACCTGTCACGTCAGGAGCGTTATGAGAATGGAGAATATCGTTGGCAGACCCTCGGCC
TTGTTCATGGCATTGTGGTCATTCTGGTTGCTCATAGCGTTCGGTTCGAAAGTGGTTTTGAAGTTATCCGTATCATCAGC
GCCCGCAAGGCAGACAGAAAAGAGAGGAATCGTTATGAGCATGGTTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8319.39 Da        Isoelectric Point: 10.1560

>AT212413 WP_083013021.1 NZ_CP080999:2066411-2066638 [Mycobacterium malmoense]
MAKRKISVTVDAHILAATDANARSAGLNRSEMIEQALRNEHLRIALHNYTNRTVPALDIDAYAQNVYRANRSSGL

Download         Length: 228 bp

>AT212413 NZ_CP107010:c3975800-3975498 [Salmonella enterica subsp. enterica serovar Paratyphi B]
ATGAGCATGGTTAAACATAAACGCGGCAACGCATCCGCGCTGAGTGCTCAGCATGAGGCTGAACTGAAGGCGCTGGTGAA
AAAATCAGATGATGAGATTGATTACAGCGACATTCCCGCTTCGGAGGATGGGCAGTGGTCTGAAGCAGTGCGTGGTAAGT
TTTTTCGCCCGTTAAAAACTCAGGCCTCGGTGCGTATTGACGCCGATGTGATGGAGTGGCTGAAACGGCCAGGAAAAGGC
TACCAGACGCGGCTCAATGCCATTCTGCGCGAGGCGATGCTGCGCGAGCAAAATAAGAAATAG

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
No matching records found

References