Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Rv0298-Rv0299/-
Location 2066411..2066937 Replicon chromosome
Accession NZ_CP080999
Organism Mycobacterium malmoense strain ATCC 29571

Toxin (Protein)


Gene name Rv0299 Uniprot ID -
Locus tag K3U93_RS09740 Protein ID WP_083013019.1
Coordinates 2066635..2066937 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name Rv0298 Uniprot ID -
Locus tag K3U93_RS09735 Protein ID WP_083013021.1
Coordinates 2066411..2066638 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K3U93_RS09720 (K3U93_09720) 2061825..2062880 + 1056 WP_083011396.1 putative zinc-binding metallopeptidase -
K3U93_RS09725 (K3U93_09725) 2063134..2064330 + 1197 WP_071509599.1 hypothetical protein -
K3U93_RS09730 (K3U93_09730) 2065005..2066270 + 1266 WP_230981624.1 group II intron reverse transcriptase/maturase -
K3U93_RS09735 (K3U93_09735) 2066411..2066638 + 228 WP_083013021.1 ribbon-helix-helix domain-containing protein Antitoxin
K3U93_RS09740 (K3U93_09740) 2066635..2066937 + 303 WP_083013019.1 toxin Toxin
K3U93_RS09745 (K3U93_09745) 2066984..2067376 - 393 WP_083013017.1 type II toxin-antitoxin system VapC family toxin -
K3U93_RS09750 (K3U93_09750) 2067373..2067618 - 246 WP_071508812.1 type II toxin-antitoxin system prevent-host-death family antitoxin -
K3U93_RS09755 (K3U93_09755) 2067759..2070419 - 2661 WP_083013015.1 circularly permuted type 2 ATP-grasp protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Ribbon-helix-helix protein, CopG

(6-41)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 10418.16 Da        Isoelectric Point: 4.6251

>T212413 WP_083013019.1 NZ_CP080999:2066635-2066937 [Mycobacterium malmoense]
VISPGDIVPRRGSDHELYVVVLSNAIHLAAATGRVVACPFIPGRVPDDAMAMVVAVRQPEGTLLPELVQWLPLSALDEPI
GAVGAAALRETTTIVTALIS

Download         Length: 303 bp

>T212413 NZ_CP107010:c3976074-3975787 [Salmonella enterica subsp. enterica serovar Paratyphi B]
ATGCCGATGGAGTTTGAATGGGATGCGAACAAGGCTAAAAGCAACCTGAGGAAGCACGGTGTCCGCTTTGAGGATGCAGT
ACTGGTGTTTGACGATCCCCGACACCTGTCACGTCAGGAGCGTTATGAGAATGGAGAATATCGTTGGCAGACCCTCGGCC
TTGTTCATGGCATTGTGGTCATTCTGGTTGCTCATAGCGTTCGGTTCGAAAGTGGTTTTGAAGTTATCCGTATCATCAGC
GCCCGCAAGGCAGACAGAAAAGAGAGGAATCGTTATGAGCATGGTTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8319.39 Da        Isoelectric Point: 10.1560

>AT212413 WP_083013021.1 NZ_CP080999:2066411-2066638 [Mycobacterium malmoense]
MAKRKISVTVDAHILAATDANARSAGLNRSEMIEQALRNEHLRIALHNYTNRTVPALDIDAYAQNVYRANRSSGL

Download         Length: 228 bp

>AT212413 NZ_CP107010:c3975800-3975498 [Salmonella enterica subsp. enterica serovar Paratyphi B]
ATGAGCATGGTTAAACATAAACGCGGCAACGCATCCGCGCTGAGTGCTCAGCATGAGGCTGAACTGAAGGCGCTGGTGAA
AAAATCAGATGATGAGATTGATTACAGCGACATTCCCGCTTCGGAGGATGGGCAGTGGTCTGAAGCAGTGCGTGGTAAGT
TTTTTCGCCCGTTAAAAACTCAGGCCTCGGTGCGTATTGACGCCGATGTGATGGAGTGGCTGAAACGGCCAGGAAAAGGC
TACCAGACGCGGCTCAATGCCATTCTGCGCGAGGCGATGCTGCGCGAGCAAAATAAGAAATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References