Detailed information of TA system TA212412

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pemIK/PRK09812-MazE
• Location: 829017..829582
• Replicon: chromosome
• Accession: NZ_CP080999
• Organism: Mycobacterium malmoense strain ATCC 29571

Toxin (Protein)

• Gene name: pemK
• Uniprot ID: -
• Locus tag: K3U93_RS03860
• Protein ID: WP_277622396.1
• Coordinates: 829017..829334 (-)
• Length: 106 a.a.

Antitoxin (Protein)

• Gene name: pemI
• Uniprot ID: -
• Locus tag: K3U93_RS03865
• Protein ID: WP_277622374.1
• Coordinates: 829349..829582 (-)
• Length: 78 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	827771..842415	14644

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (1-104)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 106 a.a.
• Molecular weight: 11253.97 Da
• Isoelectric Point: 11.6144

>T212412 WP_277622396.1 NZ_CP080999:c829334-829017 [Mycobacterium malmoense]
IFIVSLDPTQGHEQRGTRPVLIVSPTAFNRLTQTPVVLPITRGGNFARTAGFAVSLTDAGTRTTGVIRCDQPRAIDIGSR
NGRKVERVPAAILDEVLAKLATLFS

Nucleotide

• Length: 318 bp

>T212412 NZ_CP107010:3379866-3380084 [Salmonella enterica subsp. enterica serovar Paratyphi B]
ATGTCTGATAAACCATTAACTAAAACTGATTATTTGATGCGTTTACGGCGCTGTCAGACAATTGACACTCTGGAGCGCGT
CATTGAGAAAAATAAATATGAATTGTCCGACAATGAGCTGGCTGTATTTTACTCAGCTGCGGATCACCGTCTTGCAGAAT
TGACAATGAACAAACTCTACGACAAGATCCCCTCTTCAGTATGGAAATTCATTCGTTAA

Antitoxin

Protein

• Length: 78 a.a.
• Molecular weight: 8109.19 Da
• Isoelectric Point: 3.9500

>AT212412 WP_277622374.1 NZ_CP080999:c829582-829349 [Mycobacterium malmoense]
VGGSVMLAVPPAVLDMLRLHAGSAVGLSVDAGHLIVEPQTRPRYTLDELLSQCDASADLTDEDRVWLDGEPVGGELL

Nucleotide

• Length: 234 bp

>AT212412 NZ_CP107010:3379464-3379838 [Salmonella enterica subsp. enterica serovar Paratyphi B]
ATGGACGAATACTCACCCAAAAGACATGATATAGCACAGCTTAAATTTCTTTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAACCATGGCTGGGTTAATGACCCGACCTCAGCAGTCAACCTGCAGCTCAATGAGCTGATAGAAC
ATATTGCAACTTTCGCTCTTAATTATAAAATTAAGTACAATGAAGACAATAAATTGATTGCGCAGATAGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTATGGTATTAATACGCAGGATTTGCAAAAATGGCGTAAATCGGGCAACCGCCT
GTTCCGTTGTTTCGTCAACGCCACCAGGGCTAATCCTGTTAGTTTGTCTTGTTAA