Detailed information of TA system TA212411

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-yefM/YoeB-YefM
• Location: 605443..605942
• Replicon: chromosome
• Accession: NZ_CP080999
• Organism: Mycobacterium malmoense strain ATCC 29571

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: K3U93_RS02750
• Protein ID: WP_071508680.1
• Coordinates: 605443..605700 (-)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: K3U93_RS02755
• Protein ID: WP_071508681.1
• Coordinates: 605697..605942 (-)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K3U93_RS25160	600964..601098	+	135	WP_269142733.1	hypothetical protein	-
K3U93_RS02730 (K3U93_02730)	601311..603170	+	1860	WP_083012144.1	molecular chaperone DnaK	-
K3U93_RS02735 (K3U93_02735)	603167..603826	+	660	WP_083012146.1	nucleotide exchange factor GrpE	-
K3U93_RS02740 (K3U93_02740)	603863..605038	+	1176	WP_071508678.1	molecular chaperone DnaJ	-
K3U93_RS02745 (K3U93_02745)	605038..605418	+	381	WP_071508679.1	helix-turn-helix domain-containing protein	-
K3U93_RS02750 (K3U93_02750)	605443..605700	-	258	WP_071508680.1	Txe/YoeB family addiction module toxin	Toxin
K3U93_RS02755 (K3U93_02755)	605697..605942	-	246	WP_071508681.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
K3U93_RS02760 (K3U93_02760)	606410..607609	+	1200	WP_083012148.1	hypothetical protein	-
K3U93_RS02765 (K3U93_02765)	608021..608839	+	819	WP_083012151.1	class I SAM-dependent methyltransferase	-
K3U93_RS02770 (K3U93_02770)	608858..609748	-	891	WP_083012153.1	aldose 1-epimerase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (3-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (3-72)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9963.26 Da
• Isoelectric Point: 8.4774

>T212411 WP_071508680.1 NZ_CP080999:c605700-605443 [Mycobacterium malmoense]
VRLVFTPLGWADYQYWSTTDRGTQKRINRLIDDTLRDPFAGIGKLEPLRHAFAGAWSRRISEEHRLVYLVDGDDVVIVQA
RYHYT

Nucleotide

• Length: 258 bp

>T212411 NZ_CP107010:2008661-2008764 [Salmonella enterica subsp. enterica serovar Paratyphi B]
GGCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 9163.24 Da
• Isoelectric Point: 6.4705

>AT212411 WP_071508681.1 NZ_CP080999:c605942-605697 [Mycobacterium malmoense]
VAITASEARKNLFPLIEQVNNDRVPVEINSRRGDAVLISRADYEALEETAHLLRSPANARRLLESLTQAQRGEREEHTLS
R

Nucleotide

• Length: 246 bp

>AT212411 NZ_CP107010:c2008766-2008621 [Salmonella enterica subsp. enterica serovar Paratyphi B]
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAATCGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTGCG