Detailed information of TA system TA212410

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): abiEi-abiEii/AbiEii-AbiEi
• Location: 572218..574019
• Replicon: chromosome
• Accession: NZ_CP080999
• Organism: Mycobacterium malmoense strain ATCC 29571

Toxin (Protein)

• Gene name: abiEi
• Uniprot ID: -
• Locus tag: K3U93_RS02615
• Protein ID: WP_139797173.1
• Coordinates: 573135..574019 (+)
• Length: 295 a.a.

Antitoxin (Protein)

• Gene name: abiEii
• Uniprot ID: -
• Locus tag: K3U93_RS02610
• Protein ID: WP_083012113.1
• Coordinates: 572218..573132 (+)
• Length: 305 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K3U93_RS02590 (K3U93_02590)	568831..569514	+	684	WP_083012175.1	GAP family protein	-
K3U93_RS02595 (K3U93_02595)	569571..570242	+	672	WP_083012108.1	GAP family protein	-
K3U93_RS02600 (K3U93_02600)	570218..571042	-	825	WP_230981568.1	hypothetical protein	-
K3U93_RS02605 (K3U93_02605)	571039..571377	-	339	WP_083012110.1	DUF732 domain-containing protein	-
K3U93_RS02610 (K3U93_02610)	572218..573132	+	915	WP_083012113.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
K3U93_RS02615 (K3U93_02615)	573135..574019	+	885	WP_139797173.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
K3U93_RS02625 (K3U93_02625)	574350..574922	+	573	WP_071508660.1	dCTP deaminase	-
K3U93_RS02630 (K3U93_02630)	575046..576857	+	1812	WP_230981569.1	hypothetical protein	-
K3U93_RS02635 (K3U93_02635)	577145..578704	+	1560	WP_083012120.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (39-267)

Antitoxin

• AbiEi antitoxin C-terminal domain (91-243)

Sequences

Toxin

Protein

• Length: 295 a.a.
• Molecular weight: 32495.02 Da
• Isoelectric Point: 6.6085

>T212410 WP_139797173.1 NZ_CP080999:573135-574019 [Mycobacterium malmoense]
VAGLTRALVARHAAGRADAYDAALLDVAQDHLLFLLAQAANIGDGRLVFKGGTSLRKCRLGNAGRFSIDLDFGAPDDDVV
LEVCGLIDGARIGGFEFGIVSTRGDGRHWGLTVSHAELGAPRIAASVEFARRPLALPPEPLPFVPLPIHRAYGFPLPTLP
VVAEAEACAEKLARYRRVALARDLYDLNHFATRTFDEPLVRRLWVLKVWADVVDDRRGGRPLRPEDILTVRGEQDFEPDS
IGILTRPVDIPDWEARVRRRFAFLTDLDANEQRWASCNERHRSEVQDALSALRG

Nucleotide

• Length: 885 bp

>T212410 NZ_CP107010:1887756-1888109 [Salmonella enterica subsp. enterica serovar Paratyphi B]
GTGTGGACAATTAAAACAACGGATACGTTTGATCGCTGGTTTGCCTCGCTCAACGATACCGACAGGGTCAGCGTGCTTGC
AGCACTGCTGGTCCTGCGAGAAAAGGGGCCGGGTTTGTCCAGACCTTATGCCGATACGGTCAGAGGTTCCCGTTACAGCA
ACATGAAAGAACTACGTATTCAGAGTCGGGGCGAGCCGATACGGGCGTTTTTCGCTTTTGACCCGACCCGTACCGGCATT
GTGCTTTGTGCCGGAAATAAGGTCGGCAATGAAAAACGTTTTTACGATGAGATGCTCCCTGTTGCTGACAGGGAATTCAC
GAACTGGCTGAACACATTAAAAGAGAAGGAGTAA

Antitoxin

Protein

• Length: 305 a.a.
• Molecular weight: 33047.30 Da
• Isoelectric Point: 9.9380

>AT212410 WP_083012113.1 NZ_CP080999:572218-573132 [Mycobacterium malmoense]
MNLSAHGATSPLGADRRIPKWASAVIGGLARDRPIVVTTEDLALRLAEATSERDVDLAIRDLRRLGWLVGLPVRGTWAFI
PPGEAGVSDPYLPVRAWLARDHDAGCMLAGAAAAWHLGYLDRQPQGRVSLWLPAKTRLPDGLRKYVSIVKISWNIQDAAQ
LAPSTALLLRRRLDIVSWATGLPAFGPEALLVQLAARPSSFRPWADIVAHLDVLAADCVDEHLLPLLSGQSMSTWQRASY
LIDVAGDPERGAALLAKRQMKTMSVVQFTHPHIRASRSTEGVWVPKYQLVDGLVAPLLSVVGKA

Nucleotide

• Length: 915 bp

>AT212410 NZ_CP107010:1888114-1888416 [Salmonella enterica subsp. enterica serovar Paratyphi B]
ATGGGCAGAACGCTGGAACAGCTTATTGCGGATGAGAAACCTGAAGTCGTGGCCGAAGCTCAGGCGATGGCGACGGACAT
CCTGCTCAACATTCACCTTGCCGAACTGCGTGAGAAAGTACAGAAAACGCAGGTGGAGATGGCACAGGCGCTGGGCATCA
GGCAACCTACCGTTGCAGGAATGGAAAAACCAGGGCGCGATCTGAAGCTTTCCACTCTCAAACGCTACGTTGAAGCGACT
GGCGGTAAGCTACGTCTTGATGTTGAACTGCCGGATGGTTCTCACTACGGATTTGCACTGTAA