Detailed information of TA system TA212409

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 111014..111624
• Replicon: chromosome
• Accession: NZ_CP080999
• Organism: Mycobacterium malmoense strain ATCC 29571

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: K3U93_RS00555
• Protein ID: WP_083008796.1
• Coordinates: 111014..111406 (-)
• Length: 131 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: K3U93_RS00560
• Protein ID: WP_083008799.1
• Coordinates: 111403..111624 (-)
• Length: 74 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K3U93_RS00530 (K3U93_00530)	106641..107246	+	606	WP_139796726.1	class I SAM-dependent methyltransferase	-
K3U93_RS00535 (K3U93_00535)	107359..107808	+	450	WP_083009126.1	nitroreductase family deazaflavin-dependent oxidoreductase	-
K3U93_RS00540 (K3U93_00540)	107962..108636	-	675	WP_230981547.1	TetR/AcrR family transcriptional regulator	-
K3U93_RS00545 (K3U93_00545)	108706..110403	+	1698	WP_176219862.1	FAD-dependent monooxygenase	-
K3U93_RS00550 (K3U93_00550)	110421..110801	-	381	WP_230981548.1	hypothetical protein	-
K3U93_RS00555 (K3U93_00555)	111014..111406	-	393	WP_083008796.1	PIN domain-containing protein	Toxin
K3U93_RS00560 (K3U93_00560)	111403..111624	-	222	WP_083008799.1	CopG family transcriptional regulator	Antitoxin
K3U93_RS00565 (K3U93_00565)	111707..113050	-	1344	WP_083008801.1	aromatic ring-hydroxylating dioxygenase subunit alpha	-
K3U93_RS00570 (K3U93_00570)	113062..114834	-	1773	WP_083008804.1	amidohydrolase family protein	-
K3U93_RS00575 (K3U93_00575)	115014..116162	-	1149	WP_083008807.1	phosphotransferase	-
K3U93_RS00580 (K3U93_00580)	116185..116562	-	378	WP_083009128.1	STAS domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-125)

Antitoxin

• Ribbon-helix-helix protein, CopG (3-39)

Sequences

Toxin

Protein

• Length: 131 a.a.
• Molecular weight: 14877.74 Da
• Isoelectric Point: 6.3775

>T212409 WP_083008796.1 NZ_CP080999:c111406-111014 [Mycobacterium malmoense]
MIFVDTSFWAALGNATDAHHTAAERLWAAKPPFVVTSNHVLGETWTLLNRRCGHRVAVTAAAIRYSSHVRLEHITAELEE
EAWEWLARHDEREYSFVDATSFALMRKKKLRDAYAFDEDFSAAGFVELRP

Nucleotide

• Length: 393 bp

>T212409 NZ_CP107010:c988978-988451 [Salmonella enterica subsp. enterica serovar Paratyphi B]
ATGATGTTTACAGACTGGCATGAGGCCGCGATAGGGAAAACCCACAATCGAATGAATTTTGATTGTGGGGATGCCGATCT
GAACCAATTCCTACAACGCCATGCACTACAAAATCATGAGAAAGGGACAACGAAAACCTATGTTGCGCTTGATAATTCGG
ATGTTACACGTATCCACGGCTTTTACTCAGTCAGTCCTGCATCACTGATATATGCACAGGTTCCCGGCGCAATCAGCAAA
GGATTAGGGAGATATGATGTGCCAGTGTTTCGTCTGGGTCGTTTAGCCGTAGACAAATCTATGCAGGGGCAAGGGCTGGG
AGCACAACTTTTGTTATCTGCCGGAAAGCGTTGCATACAGGCGGCTTTGCAGGTCGGTGGCGTAGCCCTGCTTATTGATG
CCAAAAATAAACAGGTCTGCGACTGGTACAAAGGATTTGGCGCAGTACCATTAAACGATCAACCCCTTTCCTTGTTGCTG
TCGTTTAAAACGCTTTATGCTGCTTTATCTGCATCTGGTAGGTTATGA

Antitoxin

Protein

• Length: 74 a.a.
• Molecular weight: 8147.17 Da
• Isoelectric Point: 4.7683

>AT212409 WP_083008799.1 NZ_CP080999:c111624-111403 [Mycobacterium malmoense]
MKRLQIYIEEDLDHALGIEARRQRKSKAALIRAYVADRLGAREPDPIDAFIGSFDGGVDLSTSVDDVVYGPRE

Nucleotide

• Length: 222 bp

>AT212409 NZ_CP107010:c989265-988975 [Salmonella enterica subsp. enterica serovar Paratyphi B]
ATGAAAACCATGCCTCAGATAGCTATAGAATCTAACGAAAGACTGTCGTTACGTGTATCGACGGATGCCAAAAAGTTGAT
AGTCCGCGCTGCGGCAATCCAGCAAACCAACCTGACGGATTTTGTGGTCAGTAACGTACTACCTGTCGCACAGAAGATTG
TTGATGCCGCCGAACGGGTATATCTGACGGAGCGTGATACTCAAATGATCATGGAAATTTTAGATAACCCGCCAGCGCCG
AATGAAAAGCTTCTTGCCGCTGCTTTCGCCCTGCCGGACATGAAGAAATGA