Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 111014..111624 Replicon chromosome
Accession NZ_CP080999
Organism Mycobacterium malmoense strain ATCC 29571

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag K3U93_RS00555 Protein ID WP_083008796.1
Coordinates 111014..111406 (-) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag K3U93_RS00560 Protein ID WP_083008799.1
Coordinates 111403..111624 (-) Length 74 a.a.

Genomic Context

K3U93_RS00530K3U93_RS00535K3U93_RS00545K3U93_RS00540K3U93_RS00550K3U93_RS00555K3U93_RS00560K3U93_RS00565K3U93_RS00570K3U93_RS00575K3U93_RS00580
Location: 106641..107246 (606 bp)
Type: Others
Protein ID: WP_139796726.1
Location: 107359..107808 (450 bp)
Type: Others
Protein ID: WP_083009126.1
Location: 108706..110403 (1698 bp)
Type: Others
Protein ID: WP_176219862.1
Location: 107962..108636 (675 bp)
Type: Others
Protein ID: WP_230981547.1
Location: 110421..110801 (381 bp)
Type: Others
Protein ID: WP_230981548.1
Location: 111014..111406 (393 bp)
Type: Toxin
Protein ID: WP_083008796.1
Location: 111403..111624 (222 bp)
Type: Antitoxin
Protein ID: WP_083008799.1
Location: 111707..113050 (1344 bp)
Type: Others
Protein ID: WP_083008801.1
Location: 113062..114834 (1773 bp)
Type: Others
Protein ID: WP_083008804.1
Location: 115014..116162 (1149 bp)
Type: Others
Protein ID: WP_083008807.1
Location: 116185..116562 (378 bp)
Type: Others
Protein ID: WP_083009128.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
K3U93_RS00530 (K3U93_00530)106641..107246+606WP_139796726.1class I SAM-dependent methyltransferase-
K3U93_RS00535 (K3U93_00535)107359..107808+450WP_083009126.1nitroreductase family deazaflavin-dependent oxidoreductase-
K3U93_RS00540 (K3U93_00540)107962..108636-675WP_230981547.1TetR/AcrR family transcriptional regulator-
K3U93_RS00545 (K3U93_00545)108706..110403+1698WP_176219862.1FAD-dependent monooxygenase-
K3U93_RS00550 (K3U93_00550)110421..110801-381WP_230981548.1hypothetical protein-
K3U93_RS00555 (K3U93_00555)111014..111406-393WP_083008796.1PIN domain-containing proteinToxin
K3U93_RS00560 (K3U93_00560)111403..111624-222WP_083008799.1CopG family transcriptional regulatorAntitoxin
K3U93_RS00565 (K3U93_00565)111707..113050-1344WP_083008801.1aromatic ring-hydroxylating dioxygenase subunit alpha-
K3U93_RS00570 (K3U93_00570)113062..114834-1773WP_083008804.1amidohydrolase family protein-
K3U93_RS00575 (K3U93_00575)115014..116162-1149WP_083008807.1phosphotransferase-
K3U93_RS00580 (K3U93_00580)116185..116562-378WP_083009128.1STAS domain-containing protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-125)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-39)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14877.74 Da        Isoelectric Point: 6.3775

>T212409 WP_083008796.1 NZ_CP080999:c111406-111014 [Mycobacterium malmoense]
MIFVDTSFWAALGNATDAHHTAAERLWAAKPPFVVTSNHVLGETWTLLNRRCGHRVAVTAAAIRYSSHVRLEHITAELEE
EAWEWLARHDEREYSFVDATSFALMRKKKLRDAYAFDEDFSAAGFVELRP

Download         Length: 393 bp

>T212409 NZ_CP107010:c988978-988451 [Salmonella enterica subsp. enterica serovar Paratyphi B]
ATGATGTTTACAGACTGGCATGAGGCCGCGATAGGGAAAACCCACAATCGAATGAATTTTGATTGTGGGGATGCCGATCT
GAACCAATTCCTACAACGCCATGCACTACAAAATCATGAGAAAGGGACAACGAAAACCTATGTTGCGCTTGATAATTCGG
ATGTTACACGTATCCACGGCTTTTACTCAGTCAGTCCTGCATCACTGATATATGCACAGGTTCCCGGCGCAATCAGCAAA
GGATTAGGGAGATATGATGTGCCAGTGTTTCGTCTGGGTCGTTTAGCCGTAGACAAATCTATGCAGGGGCAAGGGCTGGG
AGCACAACTTTTGTTATCTGCCGGAAAGCGTTGCATACAGGCGGCTTTGCAGGTCGGTGGCGTAGCCCTGCTTATTGATG
CCAAAAATAAACAGGTCTGCGACTGGTACAAAGGATTTGGCGCAGTACCATTAAACGATCAACCCCTTTCCTTGTTGCTG
TCGTTTAAAACGCTTTATGCTGCTTTATCTGCATCTGGTAGGTTATGA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8147.17 Da        Isoelectric Point: 4.7683

>AT212409 WP_083008799.1 NZ_CP080999:c111624-111403 [Mycobacterium malmoense]
MKRLQIYIEEDLDHALGIEARRQRKSKAALIRAYVADRLGAREPDPIDAFIGSFDGGVDLSTSVDDVVYGPRE

Download         Length: 222 bp

>AT212409 NZ_CP107010:c989265-988975 [Salmonella enterica subsp. enterica serovar Paratyphi B]
ATGAAAACCATGCCTCAGATAGCTATAGAATCTAACGAAAGACTGTCGTTACGTGTATCGACGGATGCCAAAAAGTTGAT
AGTCCGCGCTGCGGCAATCCAGCAAACCAACCTGACGGATTTTGTGGTCAGTAACGTACTACCTGTCGCACAGAAGATTG
TTGATGCCGCCGAACGGGTATATCTGACGGAGCGTGATACTCAAATGATCATGGAAATTTTAGATAACCCGCCAGCGCCG
AATGAAAAGCTTCTTGCCGCTGCTTTCGCCCTGCCGGACATGAAGAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
No matching records found

References